Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"Zinc finger (ZNF)"”.
-
Characterisation of HP1γ in mammalian cells
… also identified HP1γ as a novel regulator of zinc finger (ZNF) genes. In summary, I identified novel post-translational modifications in HP1γ and characterised them in mESCs. I further demonstrated a role for HP1γ regulating breast cancer cell viability and identified HP1γ as a novel regulator …
-
Integration Sites in the Persistence of Latent HIV-1
… Krüppel-associated box (KRAB) domain-containing zinc finger (ZNF) genes on chromosome 19. Transcriptional and epigenetic meta-analysis of primary CD4+ T cells reveal that these specific chromosomal locations harboring integrated provirus are associated with genes downregulated upon cellular …
-
Biophysical and structural characterization of components from the nuclear pore complex and the ubiquitin pathway
… face. Both Nups contain distinct RANBP2 type zinc finger (ZnF) domains. We present crystallographic data detailing the interaction between Nup1 53-ZnFs and RanGDP. A crystal-engineering approach led to well-diffracting crystals so that all ZnF-Ran complex structures are refined to high …
-
RNA recognition: controlling RNA-protein complexes with small molecules
… in identifying important amino acids or zinc finger domains involved in recognition of MBNL1N protein to poly(CUG)RNA. To address this question we did alanine scanning for six amino acids and expressed truncated versions of the protein and studied their interaction with MBNL1N protein by …