Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Zinc Cluster"”.
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Analysis of DNA-binding Proteins in Yeast Saccharomyces Cerevisiae
… Yjl103c are little-characterized members of the zinc cluster family of transcription factors of S. cerevisiae. Characterization of their mechanism of action as well as identification of some of their target genes leads to the conclusion that they play a pivotal role in the transcriptional …
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Transcriptional Regulation of Azole Antifungal Resistance in Candida albicans
… and CDR2 have been shown to be regulated by a zinc cluster transcription factor Tac1p. A gain-of-function mutation in the gene encoding this transcription factor is responsible for the overexpression of CDR1 and CDR2. To identify the Tac1p regulon, we analyzed four matched sets of clinical …
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Adaptation of Candida albicans to Reactive Sulfur Species
… deletion mutants, only the mutant lacking the zinc cluster factor gene ZCF2 was found to be specifically sensitive to sulfite. In my thesis I show that C. albicans distinctively adapts to sulfite stress, and that Zcf2, as well as the sulfite exporter, Ssu1, are required for that response. Gene …
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Evolutionary Implications and Genetic Basis of Peroxide Survival in Saccharomyces Cerevisiae
… soil, fruit, and vineyards. Clinical isolates cluster with fruit isolates but are significantly more resistant to peroxide. Clinical isolates are genetically diverse, indicating multiple origins of the pathogenic lifestyle and eliminating the possibility that peroxide resistance is due to …
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An Investigation into Clinically Relevant Determinants of Azole Resistance in Candida albicans
… transcription factor family known as the zinc cluster transcription factors. Furthermore, genetic changes in the ergosterol biosynthesis genes, ERG11 and ERG3, encoding a C-5 sterol desaturase, also contribute to clinical azole resistance in C. albicans. The interplay of these mechanisms …
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Examining How Non-Antifungal Medications Impact Host-Fungal Interactions
… to be Tac1p-dependent for azole tolerance, a zinc cluster transcription factor commonly found with gain-of-function mutations in azole resistant isolates. Surprisingly, while we observed that aripiprazole did not alter fluconazole efficacy in a disseminated mouse model of candidiasis, drug …
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Novel Determinants That Influence Azole Susceptibility in Candida glabrata and Candida albicans
… exclusively by activating mutations in the zinc cluster transcription factor Pdr1, which controls the genes encoding the multidrug resistance transporters Cdr1, Pdh1, and Snq2. However, the specific relative contribution of these transporters to resistance is not known. In order to determine …
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ERG11-Mediated Azole Resistance in Candida albicans
… to azole resistance. Additionally, the zinc-cluster transcription factor <em>Upc2</em> has been shown to regulate the expression of <em>ERG11</em> and other genes involved in ergosterol biosynthesis.</p> <p>In a large group of clinical <em>C. albicans</em> isolates enriched for azole …