Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Zika virus infection"”.
-
Innate immunity in Zika Virus infection and neurogenesis deficits
Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised public health concerns globally. Clinical and animal studies have shown that miscarriage and brain malformation are more frequent when infection occurs during early pregnancy. ZIKV-associated microcephaly is most likely …
-
Bloodmeal determinants of Zika virus infection of Aedes (Stegomyia) aegypti mosquitoes
… in the blood of viremic mammals influence the infection of Aedes (Stegomyia) spp. mosquitoes with the arboviruses Zika (ZIKV). It has been repeatedly observed in both flaviviruses and alphaviruses that bloodmeals taken from viremic animals are more infectious than artificial bloodmeals. …
-
Neuro-zika: Brain structure and functional organization of adult humans with zika virus infection and severe neurological complications
Since its outbreak in the Americas in 2015, Zika virus (ZIKV) has become a major global health threat due to its potential to affect the nervous system. Although most adult cases show no or mild symptoms, some patients exhibit severe neurological complications. While these complications often …
-
Surveilling Women’s Bodies in Pursuit of Fetal Anatomical Normality: Framing Risk and Responsibility in American Print News Coverage of the Zika Virus
In 2015, the mosquito-borne Zika virus made international news as it spread rapidly across northeastern Brazil. These stories were not fundamentally concerned with Zika virus infection itself. The primary focus of the news coverage in 2015 into 2016 was upon the prenatal transmission of Zika virus …
-
The Effect Of Maternal Antibodies On Anti-Viral Immunity In Infant Mice
Infants are particularly vulnerable to infection and severe disease, yet we lack effective vaccines for this population. While maternal antibodies can provide protection, they also inhibit the infant’s de novo antibody response. Furthermore, maternal antibodies can exacerbate disease in some …
-
Characterization of cholesterol 25-hydroxylase expression in human macrophages
… In this study, we show that CH25H is induced by Zika virus infection or TLR stimulation. Interestingly, CH25H is induced by pro-inflammatory cytokines including 1L- 1, TNF-, and IL-6, and this induction depends on STAT-1 transcription factor. Additionally, we have observed that ATF3 weakly …
-
Crescimento e neurodesenvolvimento de crianças com a Síndrome da Zika Congênita (Salvador - Bahia)
Background: After Zika virus (ZIKV) outbreak in Brazil and around the world in 2015, it started efforts to prevent, diagnosis new cases and treat children with Congenital Zika Syndrome (CZS) that was infected during intrauterine development. Methods: Based on a case-control study, it was evaluated …
-
Scaling up 3D imaging, analysis, and culture of complex brain models
… show phenotypic changes due to neurodevelopment, Zika virus infection, and changes in organoid culture protocols Current cerebral organoid cultures lack a vascular system and are limited by nutrient transport To address this issue in vitro, we fabricated synthetic vasculature by two-photon …
-
Development of improved methodologies for the discovery of novel bioactive compounds and their application to problems of biomedical relevance.
… of the therapeutic targets studied have been Zika virus protease NS2B-NS3, acetyl and butyrylcholinesterase enzymes, the α-galactosidase enzyme and various proteins involved in diabetes. The first contribution of this thesis (which is presented as a compendium of publications) investigated the …
-
Infecção por Zika Vírus: O que o profissional de saúde da atenção básica deve saber?
A história da infecção pelo Zika vírus no Brasil se iniciou ao fim de 2014, tendo ganhado crescente importância até 2016, a partir do reconhecimento da relação entre o Zika Vírus e a ocorrência de microcefalia e outros distúrbios neurológicos pelo Centers for Disease Control and Prevention (CDC). O …
-
Characterization of Host Factors Affecting Viral Entry
The file named "RINKENBERGER-DISSERTATION-2019.pdf" is the primary dissertation file. Two (2) supplemental video files are also available and may be viewed individually.