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Showing 1 to 20 of 62 for “"Zika virus"”.
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Innate immunity in Zika Virus infection and neurogenesis deficits
Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised public health concerns globally. Clinical and animal studies have shown that miscarriage and brain malformation are more frequent when infection occurs during early pregnancy. ZIKV-associated microcephaly is most likely …
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Mechanistic analysis of the Zika virus translation-replication switch
The genomes of positive-sense RNA viruses are required for both translation and replication during infection. These two processes are antagonistic in nature, each requiring the RNA template in opposite directions. Thus, the balance between these processes during infection must be tightly regulated. …
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Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
Zika virus (ZIKV) infection causes devastating congenital abnormities and Guillain-Barré syndrome. ZIKV has two important glycoproteins, both the envelope (E) protein, and nonstructural protein 1 (NS1). The ZIKV envelope (E) protein is responsible for viral entry and represents a major determinant …
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Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
Zika virus (ZIKV) infection causes devastating congenital abnormities and Guillain-Barré syndrome. ZIKV has two important glycoproteins, both the envelope (E) protein, and nonstructural protein 1 (NS1). The ZIKV envelope (E) protein is responsible for viral entry and represents a major determinant …
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Bloodmeal determinants of Zika virus infection of Aedes (Stegomyia) aegypti mosquitoes
… Aedes (Stegomyia) spp. mosquitoes with the arboviruses Zika (ZIKV). It has been repeatedly observed in both flaviviruses and alphaviruses that bloodmeals taken from viremic animals are more infectious than artificial bloodmeals. Although this finding has been demonstrated to be at least in part …
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Vector Competence of Aedes aegypti for Zika Virus and Effects of Colonization
… the vector competence of Aedes aegypti for Zika virus (ZIKV) as well as the microbiome as a correlating factor. Ae. aegypti is the vector of multiple arthropod-borne viruses including dengue, yellow fever, and Zika virus, making it one of the most globally significant disease vectors and is …
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Development of an Attenuated Zika Virus by Editing the 5’ Untranslated Region
<p>Zika Virus (ZIKV) is a mosquito-transmitted flavivirus that usually causes no symptoms to mild febrile in humans, and it has been regarded as an insignificant pathogen to public health. However, recent outbreaks of ZIKV infection have revealed that ZIKV can cause severe neurological effects in …
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Investigating the importance of the Zika virus 3′ untranslated region to viral fitness
… Musashi 1 (MSI1) has been shown to bind to the Zika virus (ZIKV) 3′ untranslated region (3′UTR) and enhance viral replication. MSI1 is present in high levels in neural progenitor cells of the foetal brain, and previous work proposed that MSI1 could drive the pathogenesis caused by ZIKV, and …
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Development, Characterization, and Use of Molecular Tools to Study Immune-Driven Zika Virus Evolution
Emerging viruses represent a significant threat to human health. Understanding the drivers of emergence, such as viral evolution, is a critical avenue to combat these pathogens. One specific group of emerging pathogens of interest is flaviviruses. Flaviviruses are arthropod-borne viruses …
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Impact of climate- and urbanization-driven environmental change on Aedes aegypti susceptibility to Zika virus
… burden is expected to shift from malaria to arboviruses. Our current understanding of how climate- and urbanization-driven expansion of mosquitoes, such as Ae. aegypti, into new environments will impact their capacity as a vector is limited. This expansion of mosquito habitats will be accompanied …
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Comparative analysis of African and Asian/American Zika virus strains at the transcriptional and translational level
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus. Initially, ZIKV was considered of low importance as infection was usually asymptomatic or caused mild illness. However, the emergence of the Asian/American lineage, in contrast to the African lineage, was considered a public health threat. …
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An Examination of the Safety and Efficacy of Aripo-Zika as a Zika Virus Vaccine Candidate
Flaviviruses are a genus of vector-transmitted viruses that are nearly globally distributed, and flavivirus infections can result in life threatening diseases. Many flaviviruses such as Dengue, West Nile, yellow fever and Zika viruses are globally distributed. Zika virus (ZIKV) is a single strand …
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Impact of Mosquito Age and Insecticide Exposure on Vector Competence of Aedes albopictus (Diptera: Culicidae) for Zika Virus
Zika virus (ZIKV) can cause birth defects in humans and is a serious global public health concern. This arbovirus is primarily transmitted to humans by Aedes aegypti and Ae. albopictus mosquitoes; however, it can also be transmitted sexually and congenitally (from human to human). Vector-virus …
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Neuro-zika: Brain structure and functional organization of adult humans with zika virus infection and severe neurological complications
Since its outbreak in the Americas in 2015, Zika virus (ZIKV) has become a major global health threat due to its potential to affect the nervous system. Although most adult cases show no or mild symptoms, some patients exhibit severe neurological complications. While these complications often …
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Design methods for sensitive and comprehensive microbial surveillance
… surveillance through mapping the spread of Zika virus during the 2015-16 epidemic. We generate 110 Zika virus genomes from across the Americas, forming the largest and most diverse Zika virus dataset at the time. We perform a Bayesian phylogenetic analysis of Zika's spread and discover that …
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Surveilling Women’s Bodies in Pursuit of Fetal Anatomical Normality: Framing Risk and Responsibility in American Print News Coverage of the Zika Virus
In 2015, the mosquito-borne Zika virus made international news as it spread rapidly across northeastern Brazil. These stories were not fundamentally concerned with Zika virus infection itself. The primary focus of the news coverage in 2015 into 2016 was upon the prenatal transmission of Zika virus …
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The Effect Of Maternal Antibodies On Anti-Viral Immunity In Infant Mice
… Here, we establish mouse models of influenza virus- and flavivirus-specific maternal antibody transfer. We show that influenza virus-specific maternal antibodies protect infant mice from influenza disease and that Zika virus-specific maternal antibodies protect infants from Zika virus-mediated …
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Predicting the Interactions of Viral and Human Proteins
… taken place between the proteins of the virus and human proteins. The current computational models for predicting these interactions consider only single viruses for which extensive prior knowledge is available. The two prediction frameworks in this dissertation, DeNovo and DeNovo-Human, …
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Crescimento e neurodesenvolvimento de crianças com a Síndrome da Zika Congênita (Salvador - Bahia)
Background: After Zika virus (ZIKV) outbreak in Brazil and around the world in 2015, it started efforts to prevent, diagnosis new cases and treat children with Congenital Zika Syndrome (CZS) that was infected during intrauterine development. Methods: Based on a case-control study, it was evaluated …
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Developing a Novel, Safe, and Effective Platform for Generating Flavivirus Vaccines
Viruses in the Flavivirus genus (e.g., Zika, yellow fever, dengue, West Nile, and Japanese encephalitis viruses) are arthropod-borne, globally distributed, and can cause a range of neurological or hemorrhagic diseases. The ongoing epidemics of flaviviral disease consistently demonstrate the need …
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