Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Zif268"”.
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Identification of novel target genes for the plasticity-related transcription factor Zif268
… synthesis. The inducible transcription factor Zif268 has been implicated in almost all models of neuronal plasticity. Downstream targets of zif268 are widely believed to contribute to the duration and stabilisation of NMDA receptor dependent LTP which, in turn, can be linked to various models …
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Using optical tweezers, single molecule fluorescence and the ZIF268 protein-DNA system to probe mechanotransduction mechanisms
Optical tweezers instruments use laser radiation pressure to trap microscopic dielectric beads. With the appropriate chemistry, such a bead can be attached to a single molecule as a handle, permitting the application of force on the single molecule. Measuring the force applied in real-time is …
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Effects of social context on endocrine function and Zif268 expression in response to an acute stressor in adolescent and adult rats
… corticosterone concentrations and expression of Zif268 in neural regions after an acute stressor would be found in adolescent compared with adult rats. Samples were obtained before and after one hour of isolation stress and after either one or three hours of recovery back in the colony with …
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Evaluating the regulation and function of adult mouse hippocampal neurogenesis induced from running
… granule cell activity (as measured by c-Fos, Zif268, and Arc immunoreactivity), or whether only more robust activity (such as running) is necessary these changes. Results showed that the expression of c-Fos, Arc, and Zif268 in new & pre-existing neurons, as well as net neurogenesis was …
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Sequence selectivity of the resolvase catalytic domain: implications for Z-resolvase design
… length of Z-sites, what is the effect of the Zif268 DNA-binding domain on catalytic activity i.e. is it activating or inhibiting, is symmetry a prerequisite in the design of Z-sites or can a Z-resolvase catalyse recombination on sites with an odd number of bases between Zif268 binding sites …
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Electrostatics and packing in biomolecules : accounting for conformational change in protein folding and binding
… all the electrostatic interactions in the Zif268 protein-DNA complex. The net electrostatic effect was unfavorable to binding, although many individual groups or group pairs had a favorable effect, and the residues most unfavorable to binding correspond to those thought to be important for …
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An Examination of Hippocampal and Prefrontal Contributions to Spatial Learning and Memory using Immediate Early Gene Imaging
… activation in area CA1 (indexed by Zif268) was tightly linked to learning-related plasticity, and activation in CA3, prelimbic and anterior cingulate cortices was strongly associated with flexible spatial memory recall (i.e. pattern completion). Finally, we revealed that spatial …
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A Multi-Region Analysis of the Acquisition, Consolidation and Retention of Spatial Memory in the Morris Water Maze using Immediate Early Gene Imaging
… the course of spatial learning, finding that Zif268 expression was upregulated in a number of regions during early learning, and that c-Fos was upregulated during late learning. We investigated the role of IEGs in cellular consolidation at different time-points in the hours following learning, …
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Biology's wires and motors : single-molecule mechanics of M13 bacteriophage and kinesin
… DNA-binding domain of transcription factor Zif268 as minor coat fusions.
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Biological and biomimetic oxygen electro-reduction by enzymes
… (SLAC) and zinc finger DNA binding domain from Zif268 is demonstrated to bind double stranded DNA in a site specific manner while retaining enzymatic activity. The proof of principle for DNA templated enzyme immobilization demonstrates the feasibility of engineering quaternary protein structures …