Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Zebrafish embryogenesis"”.
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Characterization of the Placenta-Specific 8.1 Gene Function during Zebrafish Embryogenesis
… work, I identified plac8.1 as a PLAC8 homolog in zebrafish, a vertebrate model system amenable to various embryologic and genetic approaches. Zebrafish plac8.1 was maternally and ubiquitously expressed until four days post fertilization when its transcript became enriched in the gut. During the …
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Single Cell Methods to Learn Transcription Factor Interactions and Necessary Noncoding DNA During Zebrafish Somitogenesis
… me to build an integrated single-cell atlas of zebrafish embryogenesis and organogenesis from unpaired data to map cis-regulatory elements during zebrafish development. This approach enables single-cell resolution mapping of accessible regulatory DNA in hundreds to thousands of individually …
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Geometry and transport in development
… In the second half of this thesis, we consider zebrafish embryogenesis, during which thousands of cells collectively migrate to lay out the organism's body plan. Here, a direct physical modeling approach is hampered by the exploding complexity of a three-dimensional many-body dynamic which …
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Robust spectral representations and model inference for biological dynamics
… first to single-cell imaging data during zebrafish embryogenesis, demonstrating how our framework can compactly characterize developmental symmetry-breaking and reveal similarities between pan-embryo cell migration and Brownian particles on curved surfaces. Next, we apply the framework to …
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Molecular mechanisms of floor plate formation and neural patterning in zebrafish
… novel secreted growth factor Midkine-a (Mdka) in zebrafish. In higher vertebrates, mdk and the related factor pleiotrophin (ptn) are widely expressed during embryogenesis and are implicated in a variety of processes. The in-vivo function of both factors, however, is unclear, as knock-out mice show …
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G-Protein-Coupled Estrogen Receptor-1 (GPER): A Potential Target For Xenoestrogens During Vertebrate Embryogenesis.
… However, the role of GPER during vertebrate embryogenesis is currently unknown. Therefore, the overall objectives of this dissertation were to (1) characterize the spatiotemporal expression patterns of gper during vertebrate embryogenesis and (2) identify the potential impacts of …