Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Zebrafish development"”.
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Pumilio Regulates the Epithelial-Mesenchymal Transition and Gastrulation During Zebrafish Development
… act as translational repressors to control developmental patterning events of invertebrates, germline stem cell maintenance, and neuronal growth through deadenylation, inhibition of translational elongation, and allow access of microRNAs to their targets. pumilio proteins have yet to be …
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Roles for Chd7 in Zebrafish Development with Implications for Human Disease
… of the choanae, retardation of growth and/or development, genital and/or urinary abnormalities, and ear abnormalities and deafness) Syndrome and Idiopathic Scoliosis, however little is known about the roles this gene plays during development.</p> <p>Using zebrafish as a model system, …
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Effects of benzo[a]pyrene and CYP19a1b knockdown on zebrafish development
… would negatively impact cyp19a1b expression in zebrafish, in turn, adversely affecting development and physiology. Here, we consider whether the toxicities observed following BaP exposure are comparable to those following a transient morpholino (MO)-mediated CYP19a1b knockdown or exposure to an …
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Alternative splicing of the zebrafish myosin phosphatase targeting subunit, MYPT1, produces a novel isoform
<p>Alternative splicing of the zebrafish Myosin Phosphatase Targeting Subunit, MYPT1, produces a novel isoform (TV202). TV202 and the truncated TV202Δ ere shown to form an active complex with Protein Phosphatase 1 β (PP1β) via stress fiber assay. TV202 was also shown to be localized in the …
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CAMK-II: AN INTEGRAL PROTEIN IN CELL MIGRATION
… processes of gastrulation establish the zebrafish body plan. Gastrulation includes massive cell rearrangements to generate the three germ layers and shape the embryonic body. Three modes of cell migration must occur during vertebrate gastrulation and include: epiboly, internalization of …
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Single Cell Methods to Learn Transcription Factor Interactions and Necessary Noncoding DNA During Zebrafish Somitogenesis
… control of gene expression during embryonic development is orchestrated by complex networks of transcription factors (TFs) and their interactions with noncoding regulatory DNA elements. However, our understanding of how these elements function in vivo and how TFs cooperate to drive cell fate …
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Chemical Genetic Studies of Tumor Suppressors in the Developing Zebrafish
The zebrafish is a powerful disease model system. Its distinct advantages allow it to be used for high-throughput genetic and chemical screens with high translational potential. One mutant isolated from a screen for cell cycle deficiencies is the zebrafish cdc25a mutant standstill. This mutant …
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The role of MK2/TTP pathway in regulating early development and innate immunity in zebrafish
… syncytial layer (YSL) in teleost fishes like zebrafish. I studied the genetic pathways operating in the YSL using the betty boop (bbp) mutant. betty boop encodes mitogen activated protein kinase activated protein kinase 2a (mapkapk2a), also known as mk2a. One of the downstream targets of MK2a …
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Characterizing Tissue-Specific actinodin1 Reporter Expression in Danio rerio Fins Throughout Development and Regeneration
… the growth and structure of the fins during fin development and regeneration. Our lab has previously identified the actinodin (and) gene family, which codes for structural proteins in actinotrichia. Interestingly, the loss of this gene family has been proposed to be involved in the loss of fin …
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Function and evolution of the atypical Notch ligands Dlk1 and Dlk2 during vertebrate development
… Murine Dlk1 is widely expressed during embryonic development and targeted deletion results in defects in numerous developmental processes, such as adipogenesis, haematopoiesis, neurogenesis and skeletal muscle formation. However, the mechanisms by which DLK1 regulates these processes remains …
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Co-factors of LIM-HD transcription factors in neural development and axon pathfinding in zebrafish
The zebrafish neuromuscular system is an elegant model to study neural development. To reveal a specific programme for zebrafish motor axon pathfinding I established a method to selectively block motor axon pathfinding by interfering with LIM domain transcription factor signaling. LIM homeodomain …
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The Role of Cell Division Orientation during Zebrafish Early Development
The development of multicellular organisms is dependent on the tight coordination between tissue growth and morphogenesis. The stereotypical orientation of cell divisions has been proposed to be a fundamental mechanism by which proliferating and growing tissues take shape. However, the actual …
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The Effects of Δ9-tetrahydrocannabinol (THC) on development and hyperekplexia in embryonic zebrafish model
… well. This study demonstrates that in embryonic zebrafish, THC does not detrimentally affect the development of the synapses needed to complete the startle response. Additionally, this study supports the use of THC as a treatment option for the alleviation of spasticity caused by hyperekplexia. …
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The Effects of Amphetamine Exposure on Neurodevelopment and Behavior in Early Life Stages of Danio Rerio
… how amphetamine exposure impacts the development of stereotyped behaviors and the neural circuit that governs these behaviors. The zebrafish (<em>Danio rerio</em>) was used as our model organism because of the extensively studied developmental milestones these fish provide. Using …
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Genetic and Chemical Dissection of BloodBrain Barrier Development in Zebrafish
… cues that are essential for healthy BBB development and integrity may reveal targets for drug delivery leading to decreased progression or possible treatment of many detrimental CNS diseases. While the central features of the BBB have been accepted, an innovative model has yet to …
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Dynamics and Mechanics of Zebrafish Embryonic Tissues
Developmental biologists try to elucidate how it is possible for cells, all originating from the same egg, to develop into a variety of highly specialized structures, such as muscles, skin, brain and limbs. What organizes the behavior of these cells, and how can the information encoded in the DNA …