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Showing 1 to 1 of 1 for “"ZRANB1"”.
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Deubiquitinating Enzymes Promote Cancer Progression and Metastasis Via Regulating Protein Stability
… methyltransferase activity. Here we identified ZRANB1 (also called Trabid) as an EZH2 deubiquitinase. ZRANB1 binds, deubiquitinates, and stabilizes EZH2. Depletion of ZRANB1 in breast cancer cells results in EZH2 destabilization and growth inhibition. Systemic delivery of ZRANB1 siRNA leads to …