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Showing 1 to 20 of 44 for “"ZO-1"”.

  1. Neph-Proteine interagieren mit dem Multiadapterprotein ZO-1

    Schmidts, Miriam

    … ob Neph-Proteine mit dem PDZ-Domänen-Protein ZO-1 interagieren und ob ZO-1 so in die Neph-induzierte Signaltransduktion involviert ist. Wir konnten hier in der Tat zeigen, dass der zytoplasmatische Schwanz der transmembranären Zelladhäsionsmoleküle Neph1-3 mit dem auf der zytosolischen Seite …

    freiburg-diss Repository record

  2. Effects of fructan source and degree of polymerization on intestinal barrier function and histomorphology characteristics in obese C57BL/6 mice

    Cephas, KimberlyUniversity of Illinois at Urbana-Champaign2012

    … mice fed 10% cellulose compared to 10% inulin. ZO-1 expression was lower (p<0.05) in mice fed inulin compared to other treatments. Occludin mRNA abundance was lowest (p<0.05) in fructan sources compared to cellulose. When comparing 5% vs. 10% cellulose treatments using contrasts, 10% cellulose …

    uiuc Repository record

  3. The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier

    현, 수왕2015

    … and their major component on redistribution of ZO-1 and FoxO3a-mediated degradation of claudin-5 during ischemia/hypoxia using the mouse middle cerebral artery occlusion (MCAO) model and hypoxia model. The possible underlying mechanisms are also investigated, especially those linked to the …

    ajou Repository record

  4. Probiotic Modulation of Mucosal Immune Responses in an In Vitro Co-Culture Model

    Habil, Neama2013

    … and IHC staining of the tight junction protein, ZO-1. Probiotics selectively modulated monocyte and macrophage subset cytokine expression. Probiotics (HK and SP) suppress CD14 lo , augment CD14 hi M1, and differentially regulated TNF-α production in M2s. M2 macrophage IL-6 production was …

    plymouth Repository record

  5. Hemodynamic regulation of blood-brain barrier phenotype: A cooperative effort linking adherens and tight junction complexes

    Walsh, Tony G.Dublin City University2010

    … (TJ) proteins (e.g. VE-Cadherin, occludin, ZO-1, claudin-5) jointly consolidate the apical surface of adjacent brain microvascular endothelial cells (BBMvEC’s) creating the blood-brain barrier (BBB), a critical regulator of CNS homeostasis. Junctional disassembly and barrier dysfunction are …

    dcu Repository record

  6. Investigating viral subversion of intercellular communication

    Calhoun II, Patrick JamesVirginia Tech2020

    … conductance. Direct Cx43 interaction with ZO-1 plays a critical role in gap junction regulation. We find loss of Cx43/ZO-1 complexing during Ad5 infection by co-immunoprecipitation, with complementary studies in human induced pluripotent stem cell derived-cardiomyocytes revealing Cx43 gap …

    vt Repository record

  7. Mechanotransduction Modulates the Effect of Mechanical Forces (Fluid Shear Stress and Cyclic Strain) on Embryonic Stem Cell Differentiation Toward Vascular Endothelial Cells

    Nikmanesh, MariaThe Graduate School and University Center of The City University of New York2017

    … PECAM-1), tight junction protein genes (ZO-1, OCLD, CLD5) and vasodilatory genes (eNOS, COX-2), while it attenuated the expression of the vasoconstrictive gene ET1. After reduction of HSPG with Hep III, the shear stress-induced expression of vWF, VE-cadherin, ZO-1, eNOS, and COX-2, were …

    cuny-grad Repository record

  8. HUMAN CLCA2 IS A P53-DEPENDENT ZINC METALLOPROTEASE AND ITS INTERACTION WITH EVA1 MAINTAINS DIFFERENTIATION OF HUMAN MAMMARY EPITHELIAL CELLS

    Ramena, Grace Theresa Nicholas2017

    … CLCA2 or EVA1. We also found that CLCA2 binds to ZO-1 and beta-catenin at its c-terminus but EVA1 does not. Interestingly, we found that EVA1 does interact with ZO-1 in the presence of CLCA2, indicating that these three form a complex at the cell-cell junctions that allows stabilization of …

    siu-theses Repository record

  9. Effect of Diabetes Mellitus on Ocular Surface Tight Junctions and Glycocalyx

    Alfuraih, Saleh M2022

    … proteins: claudin-1, claudin-2, claudin-3, ZO-1, ZO-2, ZO-3, and occludin was quantified using real time PCR and western blotting. Type I diabetes was induced in mice by streptozotocin injection. Phenol red thread test, fluorescein staining and wheat-germ agglutinin corneal staining and …

    chapman Repository record

  10. Role of Protein Kinase C Zeta (PKCζ) in Regulation of Epithelial Tight Junctions

    Jain, Suneet Kumar2016

    … and induced redistribution of occludin and ZO‑1 in Caco‑2 and MDCK cell monolayers without inducing cytotoxicity. Reduced expression of PKCζ also resulted in compromised tight junction integrity. Both PKCζ pseudo substrate and reduced expression of PKCζ delayed the calcium-induced assembly …

    tenn-hsc Repository record

  11. Human coronavirus NL63 envelope protein-protein interactions: role in pathogenesis

    Schoeman, DewaldUniversity of the Western Cape2024

    … disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (ZO-1) (PDZ) domain-containing proteins, facilitating immune dysregulation and hyperinflammation. Early work on SARS-CoV-1 revealed that the PBM of its E protein serves as a pathogenic determinant, which was later …

    western-cape Repository record

  12. A Critical Role Of Cxcr2 Pdz Motif-Mediated Interactions In Endothelial Progenitor Cell Homing And Angiogenesis

    Hou, Yuning2017

    … CXCR2 possesses a consensus PSD-95/DlgA/ZO-1 (PDZ) motif at its carboxyl terminus. The PDZ motif has been reported to regulate cellular signaling and functions. Here we investigated the potential role of the PDZ motif in CXCR2-mediated EPC motility and angiogenesis. We have found that …

    wayne-thes Repository record

  13. Cxcr2 Macromolecular Complex In Pancreatic Cancer: A Potential Therapeutic Target In Tumor Growth

    Wang, Shuo2014

    … CXCR2 possesses a consensus PSD-95/DlgA/ZO-1 (PDZ) motif at its carboxyl termini, which might interact with potential PDZ scaffold/adaptor proteins. We have previously reported that CXCR2 PDZ motif-mediated protein interaction is an important regulator for neutrophil functions. Here, …

    wayne-thes Repository record

  14. In Vitro Modeling of the Blood–Retinal Barrier: Investigating the Role of Pericyte-Like Adipose-Derived Mesenchymal Stem Cells and the Application of an iBRB on-a-Chip System [Modello in vitro di barriera emato-retinica umana: effetti delle cellule staminali mesenchimali adipose differenziate verso un fenotipo pericitico e applicazione di un sistema iBRB on-a-chip]

    AGAFONOVA, ALEKSANDRAUniversità degli studi di Catania2026

    … delle proteine giunzionali VE-caderina e ZO-1. Inoltre, hanno attenuato l’espressione di mediatori pro-infiammatori e pro-angiogenici (TNF-α, IL-1β, VEGF, MMP-9) e ridotto l’attivazione dell’asse infiammatorio ERK1/2-cPLA2-COX-2. Parallelamente, hanno potenziato la risposta antiossidante …

    catania Repository record

  15. Phosphorylation kinetics of cardiac gap junction regulation during stress

    Stanley, Kari ElizabethVirginia Tech2025

    … affect protein interactions with 14-3-3 and zonula occludens-1 (ZO-1). While it is established that pS365 creates a conformational change preventing pS368, it is currently unclear precisely how pS373 regulates pS368. Further, it is unclear if alterations to these residues might impact protein …

    vt Repository record

  16. Charakterisierung der Funktion des Tight Junction Proteins hu-CLDN1 und seine Bedeutung bei der Tumorgenese

    Hövel, ThorstenUniversität Würzburg

    … daß in Brusttumorzellen, die weder Occludin noch ZO-1 exprimieren (MDA-MB-435) die physiologisch korrekte Expression von hu-CLDN1 existiert. Offensichtlich ist die Lokalisation von hu-CLDN1 von beiden Proteinen unabhängig. Die Analyse von unterschiedlichen hu-CLDN1 positiven und negativen …

    wurz-thes Repository record

  17. ¿CHIOS MASTIC GUM FROM PISTACIA LENTISCUS AS A MODULATOR OF INFLAMMATION AND INTESTINAL BARRIER FUNCTION: AN IN VITRO AND CLINICAL INVESTIGATION.¿

    XYNOMILAKIS, ORNELLAUniversità degli Studi di Milano2026

    … and faecal biomarkers (calprotectin, zonulin), were utilized to assess clinical outcomes. Concurrently, in vitro experiments compared Selpic with its isolated Supermastic® triterpene fraction in Caco-2 cells and lipopolysaccharide-stimulated THP-1 macrophages. Clinically, no …

    milano Repository record

  18. The epithelial-mesenchymal transition of hepatocyte in liver cirrhosis

    왕, 진희2011

    … cell markers such as c-Met, cytokeratin18 and zonula occludens-1 (ZO-1) in contrast to the increase of mesenchymal cell markers such as vimentin and α-SMA. Regarding the hepatocyte function, hepatocytes treated with TGF-β1 revealed a significant decrease in their ammonia-metabolizing activity …

    ajou Repository record

  19. Modulation of macrophage and epithelial cell immune defences by probiotic bacteria: immune stimulation versus suppression

    Al-Abdulwahid, Luma S.Abdulqader2021

    … also focused on the induction of the zona-occludin-1 (Zo-1), human β defensin-2 (hBD-2), and cytokine production IL-8 by Caco-2 cells. Trans epithelial electrical re-sistance (TEER) and RT-PCR measured the main cytokines studied pro-duced by Caco-2, were IL-8, also the epithelial …

    plymouth Repository record

  20. Regulating the bioactivity of placental growth factor in the aging outer retina as a new therapeutic approach to age-related macular degeneration

    Cunningham, FionaQueen's University Belfast2021

    … permeability via ERK1/2 signalling and altered ZO-1 localisation. In chapter 3 the anti-PlGF antibody THR-317 inhibited the effects of PlGF on RPE, however could not protect against hypoxia or oxidative stress. In a co-culture model, THR-317 improved barrier resistance without altering the …

    qu-belfast Repository record

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