Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 40 for “"ZIKV"”.
-
Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
Zika virus (ZIKV) infection causes devastating congenital abnormities and Guillain-Barré syndrome. ZIKV has two important glycoproteins, both the envelope (E) protein, and nonstructural protein 1 (NS1). The ZIKV envelope (E) protein is responsible for viral entry and represents a major determinant …
-
Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
Zika virus (ZIKV) infection causes devastating congenital abnormities and Guillain-Barré syndrome. ZIKV has two important glycoproteins, both the envelope (E) protein, and nonstructural protein 1 (NS1). The ZIKV envelope (E) protein is responsible for viral entry and represents a major determinant …
-
Innate immunity in Zika Virus infection and neurogenesis deficits
Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised public health concerns globally. Clinical and animal studies have shown that miscarriage and brain malformation are more frequent when infection occurs during early pregnancy. ZIKV-associated microcephaly is most likely …
-
Comparative analysis of African and Asian/American Zika virus strains at the transcriptional and translational level
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus. Initially, ZIKV was considered of low importance as infection was usually asymptomatic or caused mild illness. However, the emergence of the Asian/American lineage, in contrast to the African lineage, was considered a public health threat. …
-
Development of an Attenuated Zika Virus by Editing the 5’ Untranslated Region
<p>Zika Virus (ZIKV) is a mosquito-transmitted flavivirus that usually causes no symptoms to mild febrile in humans, and it has been regarded as an insignificant pathogen to public health. However, recent outbreaks of ZIKV infection have revealed that ZIKV can cause severe neurological effects in …
-
Zika Modulates Arthropod Histone Methylation in Mosquito Cells
… Recent studies have reported that Zika virus (ZIKV) modulates methylation of human and viral RNA important for its replication in vertebrate cells. However, little is known whether ZIKV exerts methylation in arthropod vectors. In this study, I show that ZIKV modulates S-adenosyl methionine …
-
Developing a Novel, Safe, and Effective Platform for Generating Flavivirus Vaccines
… we used to create a preclinical Zika virus (ZIKV) vaccine named Aripo/Zika virus (ARPV/ZIKV). ARPV/ZIKV is a live recombinant virus consisting of the ZIKV pre-membrane and envelope protein genes expressed on an Aripo virus backbone. In this work, we quantify the safety and efficacy of …
-
Exploiting the Conflict Within: Examining Tripartite Interactions for Development of Next Generation Mosquito Microbiome Vector Control Strategies.
… between the microbiome and Zika virus (ZIKV) in both lab reared and field collected Ae. aegypti mosquitoes. Here bacterial representatives of the Acetobacteraceae and Enterobacteriaceae families were correlated to ZIKV infection. The influence of these bacteria was found to be …
-
Impact of climate- and urbanization-driven environmental change on Aedes aegypti susceptibility to Zika virus
… traits, including susceptibility to Zika virus (ZIKV). Here, we tested the hypothesis that larval development with container-specific bacterial communities alters adult Ae. aegypti susceptibility to ZIKV. We found that plastic-derived microbiomes increase ZIKV susceptibility across multiple …
-
Characterization of Host Factors and Anti-viral Compounds for Diverse Mosquito-borne Flaviviruses
… more than 20 potential anti-Zika virus (ZIKV) therapeutics. </p><p>Two genes in particular, TTC35 and TMEM111, strongly inhibited DENV infection and, based on comparisons with published literature, implicated a larger protein, the ER Membrane Protein Complex (EMC), as a pan-flavivirus …
-
Factors influencing arbovirus transmission: vector competence and the effects of virus infection on repellent response, oxidative stress, and glutathione-S-transferase activity
Zika (ZIKV), La Crosse (LACV), and Cache Valley (CVV) viruses are mosquito-vectored diseases that cause significant morbidity and mortality in humans and animals. Transmission of these viruses are dependent on numerous factors including vector competence and the effects of mosquito-virus …
-
Characterizing Zika and West Nile virus infection in mast cells and the antibody-dependent enhancement potential mediated by dengue virus antibodies
… genus, dengue virus (DENV), Zika virus (ZIKV), and West Nile virus (WNV) are evolutionarily related mosquito-borne viruses with antigenic similarities. The antigenic similarities present between 4 circulating DENV serotypes create an immunological paradox called antibody-dependent …
-
Análise dos níveis séricos de vitamina D em pacientes infectados por arbovírus
… do país. Neste período, os vírus CHIKV e ZIKV se disseminaram nesta região, mas o impacto destas infecções ainda não está esclarecido na população. Por outro lado, a sintomatologia da infecção por ZIKV e CHIKV se confundem em alguns momentos, levando a possíveis erros diagnósticos devido à …
-
Host and viral determinants of flavivirus emergence and pathogenesis
… causes fetal harm comparable to Zika virus (ZIKV) in a mouse model of flavivirus pathogenesis during pregnancy and that SPONV can be transmitted by Aedes aegypti mosquitoes. In Chapter 3, I further characterize SPONV pathogenesis with the development of a non-human primate model of SPONV …
-
Impact of Mosquito Age and Insecticide Exposure on Vector Competence of Aedes albopictus (Diptera: Culicidae) for Zika Virus
Zika virus (ZIKV) can cause birth defects in humans and is a serious global public health concern. This arbovirus is primarily transmitted to humans by Aedes aegypti and Ae. albopictus mosquitoes; however, it can also be transmitted sexually and congenitally (from human to human). Vector-virus …
-
Yellow Fever: Role of Heterologous Flavivirus Immunity on Urban Emergence
… specifically from dengue (DENV) and Zika (ZIKV) viruses, limits YFV viremia and transmission by Ae. aegypti. We infected cynomolgus macaques with DENV or ZIKV, then challenged them 6-9 months later with YFV. We then measured viremia and disease, and allowed Ae. aegypti mosquitoes to feed …
-
Análises estruturais e de modelos de interação das proteases NS3 dos Flavivirus zika e dengue, e nsP2 dos Alphavirus chikungunya e mayaro utilizando ferramentas in silico e in vitro
… como os Flavivirus dengue (DENV) e o zika (ZIKV), e os Alphavirus chikungunya (CHIK) e o mayaro (MAYV), sendo que todos carecem de estudos estruturais mais aprofundados objetivando tanto um maior conhecimento da biologia molecular destes, quanto visando possíveis alvos para novos fármacos. …
-
Bloodmeal determinants of Zika virus infection of Aedes (Stegomyia) aegypti mosquitoes
… spp. mosquitoes with the arboviruses Zika (ZIKV). It has been repeatedly observed in both flaviviruses and alphaviruses that bloodmeals taken from viremic animals are more infectious than artificial bloodmeals. Although this finding has been demonstrated to be at least in part mediated by …
-
The development and use of cutting edge next generation sequencing methodologies to study RNA viruses
… Seurat in R. As the 2015-2016 Zika virus (ZIKV) outbreak in S. America was associated with development of microcephaly in infants born to expectant mothers infected early in pregnancy we wanted to study the transfer of ZIKV from mother to fetus. As this involves placental infection, we …
-
Neuro-zika: Brain structure and functional organization of adult humans with zika virus infection and severe neurological complications
… outbreak in the Americas in 2015, Zika virus (ZIKV) has become a major global health threat due to its potential to affect the nervous system. Although most adult cases show no or mild symptoms, some patients exhibit severe neurological complications. While these complications often present as …
Page 1 of 2