Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"ZIC3"”.
-
Mapping Domains for ZIC3 Molecular Function
… ZIC family members the protein structure of ZIC3 is relatively well characterised, yet details regarding its transactivation domain remain unknown. During embryonic development ZIC3 is involved in maintaining pluripotency of embryonic stem cells, formation of the left-right (L-R) axis and …
-
Mapping Domains for ZIC3 Molecular Function
… ZIC family members the protein structure of ZIC3 is relatively well characterised, yet details regarding its transactivation domain remain unknown. During embryonic development ZIC3 is involved in maintaining pluripotency of embryonic stem cells, formation of the left-right (L-R) axis and …
-
Identifying Novel Causes of X-Linked Heterotaxy
… in several genes can disrupt laterality, but ZIC3 variants, primarily identified through targeted sequencing of its coding region, are the only recognized cause of X-liked heterotaxy. This dissertation focuses on a heterotaxy pedigree with four affected males, demonstrating an X-linked …
-
Single-cell genomics in rabbit and mouse elucidate eutherian embryonic development
Biomedical research relies heavily on the use of model organisms to gain insight into human health and development. Traditionally, the mouse has been the favoured vertebrate model, due to its experimental and genetic tractability. Non-rodent embryological studies however highlight that many aspects …