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Showing 1 to 8 of 8 for “"ZFP36L2"”.

  1. ZFP36L2 in Development and Adulthood: A Critical Regulator of Hematopoietic Stem Cell Homeostasis

    Huang, Rui2023

    … protein members: TTP (ZFP36), ZFP36L1, and ZFP36L2, all of which can regulate gene expression by binding to specific AU-rich sequences located in the 3'-untranslated regions (3’-UTR) of mRNAs and accelerating their decay. Unique among the three, ZFP36L2 plays a pivotal role in maintaining …

    duke Repository record

  2. The RNA binding proteins ZFP36L1 and ZFP36L2 are essential for B lymphocyte development

    Galloway, Alison,University of Cambridge2014

    cambridge

  3. Die Rolle der Zinkfingerproteine ZFP36L1 und ZFP36L2 und ihrer Targets in der Imatinib-Resistenz in der chronischen myeloischen Leukämie

    Dworschak, MaikeChristian-Albrechts-Universität zu Kiel

    … welchen Einfluss die RBPs ZFP36L1 und ZFP36L2 auf die Entstehung und Manifestation der Imatinib-Resistenz haben. Zur Untersuchung von BCR::ABL1-unabhängigen Resistenzmechanismen wurde ein in vitro-Resistenzmodell etabliert, in dem unbehandelte K-562 CML-Zellen gegen Imatinib resistent …

    cau-kiel Repository record

  4. ZFP36 proteins and mRNA targets in B cell malignancies

    Alcaraz, A.University of Westminster2015

    … mRNAs. The members of the human family, ZFP36L1, ZFP36L2 and ZFP36 are able to degrade mRNAs of important cell regulators that include cytokines, cell signalling proteins and transcriptional factors. This project investigated two proposed targets for the protein family that have important roles in …

    westminster Repository record

  5. RNA binding proteins ZFP36 and ZFP36L1 limit CD8+ T cell differentiation and effector function

    Mitchell, TwmUniversity of Cambridge2021

    … of cytokine mRNA stability. Paralogs ZFP36L1 and ZFP36L2 act redundantly during thymopoiesis and in developing B lymphocytes, where they limit DNA damage response and cell cycle progression. Furthermore, ZFP36L2 has been shown to repress translation of preformed Ifng mRNA and maintain quiescence …

    cambridge Repository record

  6. Somatic evolution in healthy and chronically inflamed colon and skin

    Ólafsson, SigurgeirUniversity of Cambridge2021

    … TP53, PPM1D and NOTCH2 are positively selected. ZFP36L2 was the only gene found to be enriched in mutations that has not been previously reported in normal skin, but it is as yet uncertain if selection of ZFP36L2 mutant cells is a feature specific to psoriatic skin or not. Finally, Chapter 5 …

    cambridge Repository record

  7. Investigating the role of the post-transcriptional regulator protein ZFP36L1 in B-cell functions

    Nasir, AsgharKing's College London2012

    … consist of three other members namely ZFP36, ZFP36L2 and ZFP36L3. All the members of the ZFP36 protein family have been reported to bind to the ARE in the 3’ UTR regions of the target mRNA (via the zinc finger domains) and subsequently result in the destabilization and degradation of the mRNA. …

    kings Repository record

  8. ZFP36L3: a Unique Member of the Tristetraprolin Family of RNA-Binding Tandem Zinc Finger Proteins

    Frederick, Elizabeth2009

    … of the family members, TTP, ZFP36L1 (L1), and ZFP36L2 (L2), in inflammation, chorioallantoic fusion, and hematopoiesis, respectively. However, little is known about a recently-discovered TTP family member, ZFP36L3 (L3). Although L3 exhibits similar general biochemical functions to other members …

    duke Repository record