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Showing 1 to 13 of 13 for “"ZFP36L1"”.
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Investigating the Involvement of RNA-Binding Protein ZFP36L1 in Breast Cancer Progression
ZFP36L1 is an RNA-binding protein which functions as a mRNA decaying protein through binding to the adenylate-uridylate rich elements (AREs) located in the 3’ untranslated region (3’UTR) of mRNAs, thereby mediating mRNA decaying. ZFP36L1 has emerged as a breast cancer driver gene, exhibiting …
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Investigating the role of the post-transcriptional regulator protein ZFP36L1 in B-cell functions
ZFP36L1 belongs to a class of RNA-binding proteins known as the ZFP36 protein family which consist of three other members namely ZFP36, ZFP36L2 and ZFP36L3. All the members of the ZFP36 protein family have been reported to bind to the ARE in the 3’ UTR regions of the target mRNA (via the zinc …
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RNA binding proteins ZFP36 and ZFP36L1 limit CD8+ T cell differentiation and effector function
… regulator of cytokine mRNA stability. Paralogs ZFP36L1 and ZFP36L2 act redundantly during thymopoiesis and in developing B lymphocytes, where they limit DNA damage response and cell cycle progression. Furthermore, ZFP36L2 has been shown to repress translation of preformed Ifng mRNA and maintain …
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The Role of the RNA-binding Protein ZFP36L1 in Suppression of Replication Stress-induced Genomic Instability
… failure to preserve genomic stability. ZFP36L1, a member of the ZFP36 family of CCCH tandem zinc finger (ZF) proteins, is an RNA-binding protein that plays a crucial role in the post-transcriptional regulation of gene expression underlying physiological processes and pathological …
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Zinc Finger Protein 36L1 (ZFP36L1): Gene Expression, Regulation and Interactions with Immune Receptors in Human Tumour Cells.
The Zinc finger protein 36 like 1 (ZFP36L1) or Butyrate response factor 1 (BRF1) is involved in the differentiation, proliferation, and angiogenesis of various cell types. ZFP36L1 can positively or negatively regulate cellular processes such as transcription and signalling, depending on external …
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The Adenylate-Uridylate-Rich element RNA binding protein ZFP36L1 suppresses replication stress-induced genomic instability
The RNA binding protein (RBP) ZFP36L1, which binds to adenylate/uridylate (AU)-rich elements (AREs) (AU-RBP) in the 3’ untranslated region of many messenger RNAs, has been extensively characterised for its role in post-transcriptional control of gene expression and is reported as a newly identified …
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Die Rolle der Zinkfingerproteine ZFP36L1 und ZFP36L2 und ihrer Targets in der Imatinib-Resistenz in der chronischen myeloischen Leukämie
… es, zu analysieren, welchen Einfluss die RBPs ZFP36L1 und ZFP36L2 auf die Entstehung und Manifestation der Imatinib-Resistenz haben. Zur Untersuchung von BCR::ABL1-unabhängigen Resistenzmechanismen wurde ein in vitro-Resistenzmodell etabliert, in dem unbehandelte K-562 CML-Zellen gegen Imatinib …
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Differential regulation and functions of the ZFP36-family RNA binding proteins in CD8⁺ memory T cells
… of RNA binding proteins, including ZFP36 and ZFP36L1, contribute to the regulation of mRNA stability, protein translation and therein, T cell function. Appropriate regulation of T cell-mediated immunity is critical to enable effective yet restrained responses and limit pathogenesis. The extent …
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ZFP36 proteins and mRNA targets in B cell malignancies
… of mRNAs. The members of the human family, ZFP36L1, ZFP36L2 and ZFP36 are able to degrade mRNAs of important cell regulators that include cytokines, cell signalling proteins and transcriptional factors. This project investigated two proposed targets for the protein family that have important …
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ZFP36L3: a Unique Member of the Tristetraprolin Family of RNA-Binding Tandem Zinc Finger Proteins
… roles for three of the family members, TTP, ZFP36L1 (L1), and ZFP36L2 (L2), in inflammation, chorioallantoic fusion, and hematopoiesis, respectively. However, little is known about a recently-discovered TTP family member, ZFP36L3 (L3). Although L3 exhibits similar general biochemical …
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ZFP36L2 in Development and Adulthood: A Critical Regulator of Hematopoietic Stem Cell Homeostasis
… mammalian protein members: TTP (ZFP36), ZFP36L1, and ZFP36L2, all of which can regulate gene expression by binding to specific AU-rich sequences located in the 3'-untranslated regions (3’-UTR) of mRNAs and accelerating their decay. Unique among the three, ZFP36L2 plays a pivotal role in …
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Conditional Multifactorial Contingency (CMC) Model and Its Applications
… successfully identified Ppp1r14b (ranks 1st) and Zfp36l1 (ranks 6th) that function in oligodendrocyte lineage development, which was validated via biological knock-out experiments and, has led to genuine biological discoveries. In the scRNA-seq data normalization, experimental results show that, …