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Showing 1 to 4 of 4 for “"ZFP36 family"”.
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Differential regulation and functions of the ZFP36-family RNA binding proteins in CD8⁺ memory T cells
… bystander activation of memory T cells. The ZFP36-family of RNA binding proteins, including ZFP36 and ZFP36L1, contribute to the regulation of mRNA stability, protein translation and therein, T cell function. Appropriate regulation of T cell-mediated immunity is critical to enable effective …
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The Role of the RNA-binding Protein ZFP36L1 in Suppression of Replication Stress-induced Genomic Instability
… failure to preserve genomic stability. ZFP36L1, a member of the ZFP36 family of CCCH tandem zinc finger (ZF) proteins, is an RNA-binding protein that plays a crucial role in the post-transcriptional regulation of gene expression underlying physiological processes and pathological …
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RNA binding proteins ZFP36 and ZFP36L1 limit CD8+ T cell differentiation and effector function
… in part by RNA binding proteins (RBPs). The ZFP36 family of RBPs are key regulators of gene expression in the immune system. The founding member ZFP36 is a well-known regulator of cytokine mRNA stability. Paralogs ZFP36L1 and ZFP36L2 act redundantly during thymopoiesis and in developing B …
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ZFP36 proteins and mRNA targets in B cell malignancies
The ZFP36 proteins are a family of post-transcriptional regulator proteins that bind to adenine uridine rich elements (AREs) in 3’ untranslated (3’UTR) regions of mRNAs. The members of the human family, ZFP36L1, ZFP36L2 and ZFP36 are able to degrade mRNAs of important cell regulators that include …