Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"ZFP36"”.
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ZFP36 proteins and mRNA targets in B cell malignancies
The ZFP36 proteins are a family of post-transcriptional regulator proteins that bind to adenine uridine rich elements (AREs) in 3’ untranslated (3’UTR) regions of mRNAs. The members of the human family, ZFP36L1, ZFP36L2 and ZFP36 are able to degrade mRNAs of important cell regulators that include …
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RNA binding proteins ZFP36 and ZFP36L1 limit CD8+ T cell differentiation and effector function
… in part by RNA binding proteins (RBPs). The ZFP36 family of RBPs are key regulators of gene expression in the immune system. The founding member ZFP36 is a well-known regulator of cytokine mRNA stability. Paralogs ZFP36L1 and ZFP36L2 act redundantly during thymopoiesis and in developing B …
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Differential regulation and functions of the ZFP36-family RNA binding proteins in CD8⁺ memory T cells
… bystander activation of memory T cells. The ZFP36-family of RNA binding proteins, including ZFP36 and ZFP36L1, contribute to the regulation of mRNA stability, protein translation and therein, T cell function. Appropriate regulation of T cell-mediated immunity is critical to enable effective …
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Investigating the role of the post-transcriptional regulator protein ZFP36L1 in B-cell functions
ZFP36L1 belongs to a class of RNA-binding proteins known as the ZFP36 protein family which consist of three other members namely ZFP36, ZFP36L2 and ZFP36L3. All the members of the ZFP36 protein family have been reported to bind to the ARE in the 3’ UTR regions of the target mRNA (via the zinc …
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Molecular Etiology of Graves’ Disease and Associated Ophthalmopathy
… genes (IEGs) including CYR61, COX2, BTG2, and ZFP36 were overexpressed in active GO and to a lesser degree in chronic GO, but not in chronic lymphedema. CYR61-responsive genes were also upregulated in active GO. In Study V, associations were found between SNPs in CYR61, BTG2, and ZFP36 and GD …
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Using single cell transcriptomics to uncover mechanisms of neural development, neural stem cell quiescence and tumourigenesis
… in the maintenance of quiescence. Interestingly, ZFP36, the orthologue of tis11 is also expressed in human glioblastoma cells that are slow-cycling and express genes characteristic of mammalian NSC quiescence. Glioblastoma is a cancer with poor prognosis, as chances of tumour recurrence are high. …
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The Role of the RNA-binding Protein ZFP36L1 in Suppression of Replication Stress-induced Genomic Instability
… failure to preserve genomic stability. ZFP36L1, a member of the ZFP36 family of CCCH tandem zinc finger (ZF) proteins, is an RNA-binding protein that plays a crucial role in the post-transcriptional regulation of gene expression underlying physiological processes and pathological …
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Role of ANLN in post ischaemic angiogenesis
… A potential regulatory mechanism of ANLN by ZFP36 RNA binding proteins was identified in vascular inflammation and ischaemia in vivo and in vitro. Based on in vitro observations, ANLN expression was investigated in the ECs of the developing vasculature, and in a model of vascular injury using …
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ZFP36L2 in Development and Adulthood: A Critical Regulator of Hematopoietic Stem Cell Homeostasis
… widely expressed mammalian protein members: TTP (ZFP36), ZFP36L1, and ZFP36L2, all of which can regulate gene expression by binding to specific AU-rich sequences located in the 3'-untranslated regions (3’-UTR) of mRNAs and accelerating their decay. Unique among the three, ZFP36L2 plays a pivotal …