Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"ZEB2"”.
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Investigating the role of ZEB2 in the establishment of neuroepithelial architecture and axon tract formation
… datasets identified the transcription factor ZEB2 as a putative regulator of brain size. In this work we show that in both human brain organoids and mouse embryos ZEB2 is expressed in telencephalic neuroepithelial cells (NECs) before the switch to radial glia (RGCs). By establishing a human …
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Post-Transcriptional Regulation by microRNAS in Pregnancy and Parturition
… finger E-box binding homeobox proteins, ZEB1 and ZEB2, which act as transcriptional repressors. We also observed upregulation of the miR-200 family and downregulation of ZEB1 and ZEB2 in two different mouse models of preterm labor. We further demonstrated that ZEB1 is directly upregulated by the …
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HIV alters the expression of miRNA hsa-miR-200c-3p in B-cells, leading to enhanced migration of lymphoma cells
… line BL41. The transcription factors ZEB1 and ZEB2, which are involved in cancer cell migration, were identified as targets of hsa-miR-200c-3p. Contrary to what is expected, the mRNA expression of both genes was found to be significantly downregulated in Ramos and BL41 exposed to attenuated …
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The P63 Isoform ∆Np63Α Inhibits Epithelial – Mesenchymal Transition By Promoting The Expression of Mir-205 In Human Bladder Cancer Cells
… transcriptional repressors of E-cadherin (ZEB1, ZEB2, TWIST, SNAI1 and SNAI2). Recent publications highlight the role of microRNAs belonging to the miR-200 family and miR-205 in preventing EMT through suppression of ZEB1 and ZEB2. p53, the homologue of p63, is implicated in regulating EMT by …
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Characterising molecular and cellular mechanisms of human brain evolution using brain organoids
… morphogenesis, which in particular highlights ZEB2, a transcription factor known as a core regulator of epithelial-to-mesenchymal transition. Through gain-of-function in human, we show that ZEB2 is sufficient to trigger the transition of neuroepithelial cells which mimics nonhuman ape tissue …
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The Role of Cancer-Associated Fibroblasts In Lung Tumorigenesis
… epithelial-to-mesenchymal transition (ZEB1 and ZEB2) and promotesensitivity to a potent tumor growth factor emanating from the microenvironment(VEGFR1). Clinical trials should focus not only on the role of VEGFR1 inangiogenesis but also on the expression and activation of VEGFR1 in tumorcells by …
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Detection of Genes Influencing Chronic and Mendelian Disease Via Loss-of-Function Variation
… <em>PLRG1, SMURF1, TBX20</em>,<em> </em>and<em> ZEB2</em>).</p> <p>The analytical strategy presented here highlights the role of biologically-informed annotation on large-scale human genetic studies. The genes identified by these methods may have applications in disease prediction and drug …
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Investigation of key non-coding and coding genes in cutaneous melanomagenesis
… of the zinc finger E-box-binding homeobox 2 (ZEB2) gene. Ectopic overexpression of miR-211 in A375 melanoma cells repressed both colony formation in methylcellulose and migratory ability in matrigel, an in vitro surrogate assay for invasiveness. These findings indicate that miR-200c, miR-205 …