Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"ZEB1"”.
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Inflammation triggers Zeb1-dependent escape from tumor dormancy
… of either the EMT-transcription factor Snail or Zeb1. Furthermore, the transient induction of Zeb1 led to the generation of CD29+ CD24- metastasis-initiating cells. In mice bearing dormant disseminated D2A1-d cells, my findings demonstrated that LPS-treatment resulted in the awakening of D2A1-d …
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Post-Translational Regulation of Zeb1 Contributes to Tgfβ-Mediated Emt
… factor zinc finger E-box-binding homeobox 1 (Zeb1). Although Zeb1 has an established role in EMT the mechanism by which Zeb1 is regulated has not been fully elucidated. Here we demonstrate that Zeb1 undergoes post-translational modification and that this modification contributes to protein …
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ZEB1 is a central mediator of the Epithelial-Mesenchymal Transition
… be a possible mediator of this common pathway. ZEB1 was found to be both sufficient to induce EMT and necessary for maintaining the mesenchymal phenotype in the same cells. ZEBI and miR-200 were known to reciprocally regulate each other, but their relative importance to the EMT phenotype had …
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Regulation and Function of Zeb1 Acetylation In Lung Adenocarcinoma Progression and Metastasis
… capacity. Zinc finger E-box-binding homeobox 1 (ZEB1) recognizes and binds to E-boxes of epithelial gene promoters to repress its transcription. ZEB1 has inconsistent molecular weights, which have been attributed to post-translational modifications (PTMs). In the presented dissertation, I …
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Uncovering The Zeb1 Interactome to Identify Novel Regulators of Metastatic Non-Small Cell Lung Cancer
… factor zinc finger E-box-binding homeobox 1 (ZEB1) has been reported to uniquely correlate with NSCLC disease progression and to confer therapy resistance in multiple tumor types. Additionally, depletion of ZEB1 has been found to reverse therapy resistance, hence uncovering regulators of ZEB1 …
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SILVER NANOPARTICLES ARE EFFECTIVE FOR THE TREATMENT OF CLAUDIN LOW BREAST CANCER AND OTHER MESENCHYMAL CANCERS WITH HIGH ZEB1 EXPRESSION
A woman’s lifetime risk of being diagnosed with breast cancer is approximately 1 in 8, and it is estimated that over 40,000 women will die from BC in 2017. With advances in molecular profiling, breast cancer has been divided into 5 molecular subtypes (luminal A, luminal B, HER-2 overexpressing, …
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Post-Transcriptional Regulation by microRNAS in Pregnancy and Parturition
… zinc finger E-box binding homeobox proteins, ZEB1 and ZEB2, which act as transcriptional repressors. We also observed upregulation of the miR-200 family and downregulation of ZEB1 and ZEB2 in two different mouse models of preterm labor. We further demonstrated that ZEB1 is directly upregulated …
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The P63 Isoform ∆Np63Α Inhibits Epithelial – Mesenchymal Transition By Promoting The Expression of Mir-205 In Human Bladder Cancer Cells
… of the transcriptional repressors of E-cadherin (ZEB1, ZEB2, TWIST, SNAI1 and SNAI2). Recent publications highlight the role of microRNAs belonging to the miR-200 family and miR-205 in preventing EMT through suppression of ZEB1 and ZEB2. p53, the homologue of p63, is implicated in regulating EMT …
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The Role of The Epithelial-To-Mesenchymal Transition (Emt) In Lung Cancer Progression
… feedback loop between the transcription factor Zeb1 and the microRNA-200 family (miR-200). Furthermore, these studies demonstrated that mesenchymal lung cancer cell invasion and metastasis are dependent on interaction with the extracellular matrix (ECM). In addition to metastasis, EMT has been …
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Antagonistic Roles of miR-199a-3p/miR-214 and the miR-200 Family in the Regulation of Uterine Contractility During Pregnancy and Labor
… miR-429, and their target, transcription factor ZEB1, serve as P4/progesterone receptor (PR)-mediated regulators of uterine quiescence during pregnancy (Renthal et al., 2010). In the present study, we identified a novel role for another miR-200 family member, miR-200a, to enhance local metabolism …
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The transcription factor grainyhead-like 2 is a novel suppressor of the epithelial to mesenchymal transition
… the transcription factors Twist, Snail1/2, ZEB1/2 and goosecoid. Transforming growth factor beta can induce EMT both in the contexts of wound healing and cancer, but some cell types are resistant to this stimulus. Furthermore, knowledge of factors which stabilize the epithelial phenotype is …
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HIV alters the expression of miRNA hsa-miR-200c-3p in B-cells, leading to enhanced migration of lymphoma cells
… BL cell line BL41. The transcription factors ZEB1 and ZEB2, which are involved in cancer cell migration, were identified as targets of hsa-miR-200c-3p. Contrary to what is expected, the mRNA expression of both genes was found to be significantly downregulated in Ramos and BL41 exposed to …
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Microrna-200 Regulates Ecm-Dependent Β1-Integrin/Fak Signaling and Cancer Cell Invasion
… feedback loop with the transcriptional repressor Zeb1, yet the mechanisms on how miR-200 controls the invasive phenotype are not fully understood. Recent studies have shown that the miR-200/Zeb1 axis regulates cell-cell and cell-matrix interactions, but it has also been demonstrated that …
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Functional contribution of epithelial to mesenchymal transition program on KRASG12D targeting efficacy in pancreatic cancer
… one. Important EMT transcription factors such as Zeb1, Snail and Twist, are involved in various mechanisms, including drug resistance. It has been reported that EMT mediates chemotherapeutic and KRAS<sup>G12C</sup> inhibitor resistance, and as such, it is vital to understand the mechanisms …
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Resistance to HER2-targeted therapies in HER2-positive breast cancer
… cancer. The EMT-linked transcription factor ZEB1 was associated with acquired resistance to sapatinib in tumours that had undergone EMT and concurrently lost HER2. Generation of drug resistant cell lines failed to recapitulate the in vivo phenotype. Transient overexpression of ZEB1 in vitro …
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Epithelial to Mesenchymal Transition As A Predictor of Response to Polo-Like Kinase 1 Inhibition-Induced Apoptosis In Non-Small Cell Lung Carcinoma
… the induction of a mesenchymal phenotype using ZEB1 expression or TGF-β increased PLK1 inhibition–induced apoptosis. To elucidate the mechanisms of resistance to PLK1 inhibition, our lab compared gene and protein expression in sensitive and resistant NSCLC cell lines and we identified β-Catenin, …
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The role of seminal fluid in cervical squamous carcinoma progression: Impact on cell proliferation, EMT, motility and gene expression
… of EMT transcription factors Snail, Twist and ZEB1. EMT induction was confirmed by the increase of N-cadherin and a decrease in E-cadherin protein expression. Additionally, results showed that the induction of EMT transcription factors Snail, Twist and ZEB1 by SF occurs via EP4 receptor, ERK1/2 …
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Novel Regulators of Cellular Secretion Alter The Tumor Microenvironment to Drive Metastasis
… by the loss of miR-200 and miR~96 are Zeb1 and Foxf2, which associate with metastasis and poor patient prognosis. (2) Altered Golgi morphology and enhanced Golgi exocytosis during EMT promotes lung cancer metastasis. Zeb1-mediated EMT regulates Golgi dynamics and integrity, thereby …
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The Role of Cancer-Associated Fibroblasts In Lung Tumorigenesis
… epithelial-to-mesenchymal transition (ZEB1 and ZEB2) and promotesensitivity to a potent tumor growth factor emanating from the microenvironment(VEGFR1). Clinical trials should focus not only on the role of VEGFR1 inangiogenesis but also on the expression and activation of VEGFR1 in …
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