Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"ZDF"”.
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The Role of Complement in Ischemic Heart Disease in Type 2 Diabetes Mellitus
… excessive response of the Zucker Diabetic Fatty (ZDF), a rat model of T2DM, to myocardial I/R injury. Following 30min of coronary artery occlusion and 120min of reperfusion we measured C3 deposition, PMN accumulation, PMN CD11b expression, and ICAM-1 expression. We found significantly more C3 …
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Cardiovascular function in animal models of metabolic syndrome and type 2 diabetes : the role of inducible nitric oxide synthase (iNOS)
… of type 2 diabetes (Zucker diabetes fatty or ZDF rats) and two models of metabolic syndrome (fructose-fed rats and Zucker obese rats), and to provide direct evidence linking iNOS and oxidative stress to abnormal cardiovascular function in these disorders. Blood pressure, cardiac contractility, …
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Much a coup about nothing? Was Zimbabwe's 2017 ‘military-assisted change of government' an ‘unconstitutional change of government' as defined by applicable international law? Did the relevant international bodies respond to it in accordance with their own rules?
… Armed members of the Zimbabwean Defence Forces (‘ZDF') took to the streets of Harare in armoured personnel carriers and quickly asserted control over key locations. The ZDF quickly moved to assure civilians that this was ‘not a coup' and that the military was merely purging ‘criminal elements …
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Controlled Release of Insulin and Modified Insulin from a Novel Injectable Biodegradable Gel
… lowering effect of insulin in type-2 diabetic ZDF rats was investigated. Insulin formulations containing varying concentrations of different water-soluble and water-insoluble zinc salts were prepared and injected subcutaneously in type-2 ZDF rats and blood glucose concentration lowering effect …
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The compounding effects of obesity on the development of Intimal Hyperplasia following vascular intervention : a histopathological analysis
… Zucker fatty rats and Zucker diabetic fatty rat (ZDF) were subjected to balloon injury with or without stenting. The development of IH, along with the histological response to injury was analyzed.
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Sex differences in aortic endothelial function of diabetic rats: Possible involvement of superoxide and nitric oxide production
… of disease) and Zucker type 2 diabetic fatty (ZDF) rats. Endothelium-dependent vasodilation (EDV) to acetylcholine (ACh) was measured in aortic rings pre-contracted with phenylephrine (PE) before and after pretreatment with MnTmPYP (10 mM), a superoxide scavenger, or apocynin (100 μM), a NADPH …
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Úloha stabilních analogů peptidu uvolňujícího prolaktin při obezitě a hypertenzi
… a dva modely s nefunkčním leptinovým receptorem: ZDF (Zucker diabetic fatty) potkani a spontánně hypertenzní obézní (SHROB) potkani. Příjem vysokotukové diety zvýšil u myší i potkanů tělesnou hmotnost a krevní tlak. Dvoutýdenní intraperitoneální léčba palmitovaným analogem PrRP31 významně snížila …
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Ceramide Accumulation in the Alpha Cell Drives Glucagon Secretion and Hyperglycemia
… (1). More importantly, their later research in ZDF diabetic fatty rats showed an increase in serine palmitoyl transferase, the rate limiting enzyme in ceramide synthesis, in islets of obese fa/fa ZDF rats compared to lean mice of the same age (2). Blockade of ceramide synthesis in these islets …
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Mechanisms of regulation of islet function by nadph oxidase
… the above observations in Zucker Diabetic Fatty [ZDF] rat model, which mimics type2 diabetes in humans, characterized by obesity, hyperinsulinemia, hyperglycemia and gradual decline in â-cell function. The results obtained were comparable with clonal â-cells. Islets derived from ZDF-rats presented …
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Children’s public service broadcasters and their challenges in the online era: a comparison between the UK and Germany
… broadcasters SWR, BR (ARD), BBC and ZDF and ARD/ZDF’s joint children’s channel KiKA, while the original research further narrows the focus down to those services on new online and mobile platforms. The research applies a qualitative comparative approach based on a triangulation of …
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The Mechanism of Palmitate Decreased Glucose Transpoter 4 Expression in C2 Myotubes
… 고농도 지방산의 지속적 노출에 의한 인슐린 저항성 및 GLUT4 양적 감소 21 1. ZDF 백서의 근육에서 GLUT4 mRNA 감소 21 2. 인슐린 저항성 및 GLUT4 양적 감소 21 3. GLUT4 promoter assay 22 4. mRNA 안정성 (Stability) 22 B. 고농도 지방산의 지속적 노출에 의한 GLUT4 양적 감소 기전 분석 27 1. 고농도 지방산에 의한 beta-oxidation 관련 약제의 영향 27 2. 고농도 지방산에 의한 synthesis 관련 약제의 영향 27 3. 고농도 지방산에 …
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The impact of glucotoxicity on pancreatic β-cell function
… diabetic animal models i.e. mild hyperlipidemic ZDF (fa/fa) and hyperglycemic GK rat, we found that chronic hyperglycemia in the absence of hyperlipidemia almost abolish GPR40 expression in the islet cells and abrogate the FFA-induced secretory effects. We suggest that this might be an important …
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Islet Dysfunction In Diabetes
… were able to corroborate these findings in the ZDF rat, an animal model for T2DM and in islets obtained from human donors with T2DM. Also, our findings revealed significant attenuation of glucose-stimulated insulin secretion [GSIS] in beta cells exposed to glucotoxic conditions suggesting …
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Gesprochensprachliche Elemente in deutschen Zeitungen
… (weil mit Verbzweitstellung: "Weil, heute ist ZDF dran am Übertragen und nicht Sat 1, wie am vergangenen Sonnabend.") zu finden sind. Im stilistischen Bereich ist die Werbesprache und die Chatkommunikation ("Oder Kisskiss *snog*") als Vorbild produktiv. Die Verwendung ist dabei nicht auf …
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Linking Environmental Toxicant Exposure To Diabetes Susceptibility
… promotes the development of Type 2 diabetes. In ZDF rats we identified Pb-induced defects in hepatic glucose output and postprandial glucose clearance as well as key histological aspects of Pb-exposure, including islet abnormalities and increased β-cell compensation. And in hIAPP transgenic mice …
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
… beta cells isolated from Zuker Diabetic Fatty (ZDF) or Otsuka Long-Evans Tokushima Fatty (OLETF) rats. These works suggest that energy depletion, by shortage of Krebs intermediates, may play a critical role for HG/PA-induced beta cell death.