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Showing 1 to 5 of 5 for “"ZAPA"”.
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Understanding protease-mediated host-pathogen interactions in <i style="">Proteus mirabilis</i>
ZapA is a zinc-dependent metalloprotease secreted by <i>Proteus mirabilis</i>, a Gram-negative opportunistic pathogen that is primarily implicated in catheter-associated urinary tract infections (CAUTIs), which account for 80 % of all nosocomial infections. ZapA is an important virulence factor …
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INSIGHTS INTO POLYMERISATION OF FTSZ AND OTHER CYTOMOTIVE FILAMENTS
… widely conserved filament cross-linking protein ZapA. I also present the development of a high- throughput assay for detection of better FtsZ inhibitors, which uses principles derived from the structural studies. Finally, I demonstrate that the conformational switch upon polymerisation seen in …
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Structure-function analysis of ZapC, an FtsZ-ring stabilizer, in Escherichia coli cytokinesis
… amongst FtsZ protofilaments in the Z-ring. ZapA-D are recruited during early cytokinesis and have overlapping functions in stabilizing FtsZ at midcell, but share no primary sequence identity. The focus of this study is on ZapC, a small cytoplasmic protein that is conserved in the gamma …
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Design and Syntheses of Potential Drugs Based on GABA(A) Receptor Pharmacophores
… We have also investigated the agonism of four ZAPA derivatives in 36Cl- uptake functional assay. Two of them are found to be as potent as GABA. In our studies of 1,4-benzodiazepines, our goal was to synthesize three different subtypes of quaternary 1,4-benzodiazepines by use of the memory of …
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Characterization of ftsA conditional lethal mutants shows that FtsA is required at early and late stages of cell division in Streptococcus pneumoniae
… FtsA interacts, at least, with itself, FtsZ, ZapA and the septal PBP, FtsI. Despite the advances in understanding cell division in Streptococcus pneumoniae, little is known about the early stages of the process. Here I present the characterization of S. pneumoniae ftsA thermosensitive (Ts) …