Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"ZAP70"”.
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Functional role of ZAP70 in Chronic Lymphocytic Leukaemia
… chromosomal aberrations, CD38 expression and ZAP70 expression. Of these 4 prognostic markers, some are very labour intensive and not easy to perform on a routine basis, however ZAP70 expression has been a reliable predictor for the prognosis of CLL. In this study, I investigated the role of …
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Ldoc1, A Novel Biomarker of Prognosis In Chronic Lymphocytic Leukemia
… with other markers of poor prognosis, including ZAP70 protein and cytogenetic abnormalities of poor prognosis (deletions of chromosomes 6q21, 11q23, and 17p13.1, and trisomy 12). CLL cases positive for LDOC1 mRNA had significantly shorter overall survival than negative cases. Moreover, in a …
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CD180/RP105 Toll-like Receptor (TLR) mediated signalling in Chronic Lymphocytic Leukaemia
… significantly induced phosphorylation of ZAP70/Syk, ERK, p38MAPK, and AKT. In contrast, CD180-mediated signalling in NR CLL cells did not progress downstream from ZAP70/Syk phosphorylation indicating a block in activation of downstream protein kinases, and possible anergy. To further …
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Studies on the Leukocyte-Associated Ig-Like Inhibitory Receptor-1 Signaling Pathway in T Lymphocytes
… in Jurkat-LAIR1 cells resulted in ablation of ZAP70 and ERK phosphorylation regardless of LAIR-1 signaling and TCR signaling, indicating that SHP-1 is required for activation of ZAP70 and ERKs in T cells. Thus, SHP-1 may play a dual function; an intermediate for LAIR-1 to regulate signaling …
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The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling
… for this pathway to occur such as CD45, Lck and Zap70. In this study evidence is presented to show that two further TCR-associated proteins are phosphorylated in response to the IFNAR; the 95kDa guanosine nucleotide exchange factor, Vav, and the 76kDa adaptor protein Slp76. This proceeds in a …
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Functional interaction between CD180 Toll-like receptor (TLR) and B cell receptor (BCR) in the biology of Chronic Lymphocytic Leukaemia (CLL)
… significantly induced phosphorylation of ZAP70/Syk, ERK, p38MAPK, and AKT in R-CLL cells whilst CD180-mediated signalling in NR CLL cells did not progress downstream from ZAP70/Syk phosphorylation indicating a block in activation of downstream protein kinases, and possible anergy. However, …
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The expression and signalling patterns of CD180 toll like receptor in Chronic Lymphocytic Leukaemia (CLL)
… and other prognostic markers such as CD38 and ZAP70 displayed any correlation with the known cytogenetic aberrations:TP53 and DLEU1. Our results suggested that CLL cells with DLEU1 deletion are characterised by the negative expression of both, CD180 and CD38, and this might have a significance …
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Functional relationships among lck kinase and the lat and grb2 adaptors in the intracellular signaling cascade of the tcr/cd3 complex: implications in thymic development and lymphocyte activation
… Y132 of LAT, makes it a worse substrate for ZAP70 by reducing the rate of phosphorylation with respect to the other LAT tyrosines. This mechanism could constitute an essential step in the kinetic proofreading model for ligand discrimination. To elucidate the biological function of this …
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The Safety and Immunostimulatory Properties of Amorphous Silica Nanoparticles <10 nm in Diameter
… The nanoparticulate induced signalling through Zap70, LAT, and, eventually, through NFAT but not through MAPK. Similar signalling in the literature has been shown to induce a hyporesponsive T cell state (anergy) or activation induced cell death. The induction of the CD25 and CD69 T cell …
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Understanding T cells in type 1 diabetes: a role for c-Maf and characterization of intracellular signaling following engagement of transgenic Ly49A.
… (TCR) and Ly49A engagement, phosphorylation of Zap70, Erk1/2 and c-Jun were significantly diminished. Kinetic studies indicated that Ly49A did not simply delay activation but had a long-lasting effect. In contrast, when only costimulatory signals were provided through CD28, Ly49A engagement did …