Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"ZAP-70"”.
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Regulation antigeninduzierter T-Zell Aktivierung durch Integration stimulierender und inhibitorischer Signale
… mit der TCR-assoziierten Syk-ähnlichen Kinase ZAP-70 zu kooperieren vermag. Die Verknüpfung beider Kinasen mit den nachgeschalteten Signaltransduktionskaskaden erfolgt durch die Phosphorylierung spezifischer Substrate, welche zu Beginn dieser Untersuchungen noch größtenteils unbekannt waren. …
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Stochastic regulation of signaling in lymphocytes
… complex and the alternative pathway directly via ZAP-70 molecules. In both of studies, we bring together computational tools, stochastic theories and cell biology by collaborating with biologists, Professor Jeroen Roose and Dr. Jesse Jun, in University of California, San Francisco. In biochemical …
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Cll Metabolism Is Regulated By Prognostic Factors, Modulated By Stroma and Abrogated By Pi3K Inhibition
… associated with poor prognostic factors such as ZAP 70 positivity, unmutated IgVH, high β2M levels, and higher Rai stage.<strong> </strong>Co-culture with the NK-tert stromal line increased basal OCR and maximum respiratory capacity of CLL at 2 or 24 hours of interaction, without significant …
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The roles of clustered membrane proteins in T-cell signaling
… and Linker of activated T cells (Lat). Active ZAP-70 molecules, which phosphorylate tyrosine residues of Lat molecules, are generated from the clustered TCR molecules. Using spatial Gillespie simulation and mathematical modeling, I found that clustered proteins may suppress the probability of …
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B Cell Activation: The Regulation by T Cells and the Induction of the Protein Tyrosine Kinase SYK
… a cDNA clone of human syk that, along with ZAP-70, defines a novel family of protein tyrosine kinases. We modeled the SH2 domains of syk to design a mutational analysis of the structure and function of syk. To facilitate the study of B cell responses to membrane immunoglobulin-independent …
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Defining the Role of CD3 Zeta ITAMs in T Cell Signaling and Development
… suggested that p21, which exists complexed to ZAP-70, is excluded from new TCR-driven signals. Conventional T cell development proceeds with as few as 4/10 functional CD3 ITAMs; however, iNKT cell development was significantly reduced when one CD3 zeta ITAM was rendered non-functional. This was …
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Differentiation into Effector Cells with Distinct Memory Fates: Contributions of Viral Dose and Functional Avidity
… in sensitivity was correlated with decreased ZAP-70 and Lck expression as well as their phosphorylated products, both important molecules in T cell receptor membrane proximal signaling. These results highlight the potential contribution of avidity in the differentiation and evolution of the T …
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Costimulatory function of CD44
… in the phosphorylation of the TCR z-chain and ZAP-70. Notably, cross-linking of CD44 was binding-site dependent and was only effective when supporting colocalization of the TCR/CD3 complex and CD44. Cross-linking of CD44 via immobilized IM7 also induced profound changes in cell morphology, …
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Die Hämatopoetische Progenitor Kinase (HPK) 1 und NFAT-Transkriptionsfaktoren unterstützen die Apoptose von T-Lymphozyten
… lokalisierten HPK1 sind sowohl Lck als auch ZAP-70 notwendig [Liou et al., 2000; Liu et al., 2000a; Ling et al., 2001]. Diese Daten legen eine mögliche Funktion von HPK1 bei der TZR-vermittelten Signalübertragung nahe. Trotzdem konnte bisher eine physiologische Rolle der HPK1 im Rahmen der …
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Mechanismen der TZR-abhängigen und -unabhängigen Aktivierung primärer T-Zellen der Ratte durch CD 28
Zur Aktivierung ruhender T-Zellen sind zwei Signale erforderlich: Eines wird antigen-abhängig über den T-Zellrezeptor (TZR) gegeben, ein zweites erfolgt über kostimulatorische Rezeptoren. Unter den bekannten kostimulatorischen Molekülen ist CD28 das potenteste. Die mitogene Aktivität einiger …