Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Z-disc"”.
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Junction Specificity and Transmembrane Linkages of Integrins
… namely, a subset of focal adhesions, the Z-disc of muscle, and neuromuscular junctions. Immunopurification of the antigen to this antibody from chicken brain tissue yielded a complex of three prominent proteins with mobilities of 36, 30 and 18 kD. Amino acid sequencing of the purified …
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The Role of Two Homologous E3 Ligases In Muscle Physiology
… (also known as TCAP). TCAP is a sarcomeric z-disc protein expressed in cardiac and skeletal muscle that is critical to proper structure and function of muscles. Through preliminary experiments, we identified TCAP as a novel shared target substrate of FBXL3 and FBXL21. Here we report that FBXL3 …
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Human FRG1 is an Actin-Bundling and a RNA-Associated Protein with Distinct Subcellular Localizations
… FRG1 eventually associating with the matured Z-discs. The Z-disc localization is confirmed in mouse myofibers, suggesting FRG1 may have a muscle-specific function involved in sarcomere maintenance or signaling. The nuclear fraction of the endogenous FRG1 is localized in nucleoli, Cajal bodies, …
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PATHOGENIC MECHANISMS OF TRUNCATED TITIN IN DILATED CARDIOMYOPATHY
… titin binds to the thick filament and Z-disc under sarcomeric stretch, even at supraphysiological physiological sarcomere lengths. By treating stretched sarcomeres with a high-salt solution, we can detach truncated titin from the thick filament, whereupon it recoils to the Z-disk. These …