Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Z-VAD-FMK"”.
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Synergism of Gingipains in Endothelial Cell Adhesion Disruption and Apoptosis
… by synthetic peptide caspase inhibitors. Using z-VAD-FMK to inhibit Kgp activity and leupeptin to inhibit Rgp activity, we further investigated the specific roles of the gingipains in producing the observed morphological changes. In the presence of z-VAD-FMK or leupeptin, gingipain-induced cell …
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Untersuchungen zur Signaltransduktion Ajoen-induzierter Apoptose in Leukämiezellen
… nötig, da der Breitbandcaspaseinhibitor z-VAD-fmk die durch Ajoen provozierte DNA-Fragmentation völlig verhindert. 2) Die Ajoen-induzierte Apoptose wird nicht durch den Todesrezeptor CD95 vermittelt. Dafür sprechen folgende Ergebnisse: a) Unsere HL-60 Zellen exprimieren den CD95-Rezeptor, …
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Inflammasome activation in THP-1 target cells triggered by pathogenic Naegleria fowleri
… trophozoites penetrate the nasal mucosa and invade the olfactory bulbs, resulting in intense inflammatory reactions in the forebrain tissue. To investigate what kinds of inflammasome molecules are expressed in target cells due to N. fowleri infection, human macrophage cells (THP-1 cells) were …
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Exploring new regulators of innate immune signalling pathways with a particular focus on inflammasomes
… of NLRP3 (with MCC950) and caspase (with<br/>z-VAD-FMK) activity. This study found that Kp activated the NLRP3 inflammasome, as well as other caspase-1/11-dependent and independent pathways that contributed to the production and secretion of IL-1β, but that these did not impact the bactericidal …
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Effect of Combination of Aspirin and TRAIL in HeLa Cervical Cancer Cells
… were inhibited by a pan-caspase inhibitor z-VAD-fmk. Interestingly, TRAIL caused the activation of ERK, whereas the ERK activation was blocked by aspirin. As a result, the activation of ERK decreased and additionally, Mcl-1 also decreased in combination treatment. Conclusion: TRAIL in …
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Loss of Caspase-8 Function In Combination With Smac Mimetic Treatment Sensitizes Head and Neck Squamous Carcinoma to Radiation Through Induction of Necroptosis.
… when combined with pan-caspase inhibitors zVAD-FMK or emricasan. Strikingly, inhibition of CASP8 function via knockdown or emricasan treatment was associated with enhanced radiation killing by Birinapant through induction of necroptosis. In a syngeneic mouse model of oral cancer, Birinapant, …