Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Z-DNA"”.
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The Influence of the Cellular Environment on Z-DNA Formation
… influence of cosolutes on the transition from B-DNA to Z-DNA in model DNA duplexes. Distinct from the familiar right-handed BDNA helical conformation, Z-DNA is a left-handed double helical structure with its phosphodiester backbone arranged in a zig-zag pattern that is unique to Z-DNA. Moreover, …
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C8-Arylguanine Modified Hairpin Oligonucleotides: Synthesis, Conformational Analysis, and Tools for the Investigation of Z-DNA Formation
Z-DNA is the only DNA conformation that has a left-handed helical twist. Z-DNA has been implicated in carcinogenesis from its role in gene expression. Z-DNA formation has been linked to mutagenesis since it may play a role in genetic instability and can induce gene deletions. However, the specific …
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Determinants of crystal packing by nucleic acid polymers : examples of Z-DNA and cytosine-tetraplex crystal structures
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.
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(A). Regulation of B-/Z-DNA transition in modified oligonucleotides; (B). Synthesis of cationic BODIPY analogues for antimicrobial and anticancer applications
… the impact of this modification on the B→Z-DNA transition. Circular dichroism study showed that the incorporation of a single LNA-dG unit into d(CG)6 at internal positions virtually suppressed Z-DNA formation at 4 M NaCl concentration, whereas the presence of single LNA-dG unit towards the …
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The Influence of Osmolytes on Nucleic Acid Helical Conformations
… on the transition of helical conformation from B-DNA to Z-DNA. Distinct from the familiar, right-handed B-DNA, Z-DNA is a left-handed double helical structure with its phosphodiester backbone arranged in a pronounced zig-zag pattern. This pattern, unique to Z-DNA is formed from alternating …
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Double-Strand Break Repair Pathways In Dna Structure-Induced Genetic Instability
… In the absence of exogenous sources of DNA damage, the DNA structure itself has been implicated in genetic instability. When the canonical B-DNA helix is naturally altered to form a non-canonical DNA structure such as a Z-DNA or H-DNA, this can lead to genetic instability in the form of …
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THE ROLE OF DNA SENSOR SIGNALLING PATHWAY IN LYMPHOMA
… of viral nucleic acids. Many intracellular DNA sensors induce the expression of pro-inflammatory cytokines and type I interferons (IFN) through the activation of the transcription factors including IFN regulatory factor 3 (IRF3). Interestingly, we found evidence that the same defense …
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DNA based networks, nanostructures, and meta-stable states
… important materials is deoxyribonucleic acid (DNA). DNA has several unique properties that make it a good candidate for nanotechnology research. The primary aim of this research is to use DNA three-way junctions as building blocks and to assemble them into a huge DNA networks through self …
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Characterisation of DNA i-motif structures in the human genome and the role of non-canonical nucleic acid structures
… Varying in nucleic acid composition, such as DNA and RNA, or by structure, such as linear or circular structures. In the complex variety of nucleic acid forms, non-canonical nucleic acid structures have emerged as a research frontier, hence their unique properties compared to their more stable …
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Re-evaluation of analytical chemistry techniques in studying DNA structures
… to examine the structural changes that DNA adopts when subjected to a number of external/internal factors. A self-complementary sequence, d(CG)9, and a non-self-complementary sequence (mixed sequence) were used to study the conformational effects displayed by each type of oligonucleotide …
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Structural determinants of mutability across cancer genomes
… of this variation. Here the role of alternative DNA structures was investigated across a multitude of whole-genome sequenced cancers. Sequences that are predisposed to fold in alternative DNA structures can be identified by the primary DNA sequence of the human genome and are collectively known …
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Studies of the Unusually Extended DNA Inside the Pf1 Bacteriophage by Solid-State NMR and Computational Methods
The internal DNA of the Pf1 bacteriophage is known from its dimensions to be the most extended naturally occurring DNA. Understanding its conformation is critical to further insights about DNA stability and packing processes in Pf1 and similar filamentous phages, and is of broader interest to …