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Showing 1 to 6 of 6 for “"Ynones"”.
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Underutilized Dineophiles: Asymmetric Diels-Alder Reaction of Ynones and Ynoates with Oxygen-Functionalized Dienes
… an enantioselective Diels-Alder reaction using ynones and ynoates (Figure A1).The proposal is to use electron-rich dienes, similar to Danishefsky's diene, in order to generate 1,4-cyclohexadienes that have functional groups that can take part in further chemoselective transformations. The …
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Intramolecular [4+2] cycloadditions of conjugated ynones and related species ; Studies directed toward the total systhesis of glycinoeclepin A
The intramolecular [4 + 2] cycloaddition reactions of c,-alkynyl carbonyl compounds are described. This reaction, the first heterocyclic variant of the enyne cycloaddition reaction, affords a product with a dihydroisobenzofuran ring system. For this reaction, we propose a mechanism in which a …
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Metal-free methodology for the preparation of ynones using potassium alkynyltrifluoroborates and its application to the synthesis of natural products
… straightforward procedure for the preparation of ynones from potassium alkynyltrifluoroborate salts and acyl chlorides or anhydrides has been developed. The one-pot reaction is advantageous in that it does not require exclusion of air or water, is operationally simple, has broad substrate scope, …
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Multi-component Reactions Initiated via Sonogashira Coupling
… of arylbromides, it was possible to synthesize ynones that are highly reactive and valuable intermediates. Furthermore, we succeeded in directly converting these building blocks into beta-enaminones, pyrimidines and halofurans in a one-pot three-component fashion.
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Development and Application of Computational Methods for the Prediction of Chiral Phosphoric Acid Catalyst Performance
… spirocyclisation reaction involving aromatic ynones. In this study I show that enantioselectivity is governed by the non-covalent interactions between the aromatic group of the ynone and the 3,3’ substituent. I was able to propose synthetic modifications to the substrate used in this reaction, …
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Exploring Enantioselective and Multicomponent One-Pot Reactions Utilizing Alkynes as Linchpins Toward Biologically Active Molecules
Robust synthetic methodology to make complex small molecules that are of biological importance is a highly investigated area. Utilizing fundamental bond-making reactions, like the Diels-Alder reaction and the Nazarov cyclization, in new efficient one-pot methodologies can help to expand the scope …