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Showing 1 to 4 of 4 for “"Ynone"”.
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Novel Conjugate Additions and Cyclizations on Multiyne Systems
… by a nucleophile connected to the 1,3-diynone moiety. This tethering promotes a sequential 1,6-addition with a C-nucleophile followed by a 1,4-addition with an O-nucleophile to generate 2-methylene-2H-pyrans. In the second approach, a zwitterionic intermediate generated from acetyl ketene …
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Development and Application of Computational Methods for the Prediction of Chiral Phosphoric Acid Catalyst Performance
… spirocyclisation reaction involving aromatic ynones. In this study I show that enantioselectivity is governed by the non-covalent interactions between the aromatic group of the ynone and the 3,3’ substituent. I was able to propose synthetic modifications to the substrate used in this reaction, …
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Metal-free methodology for the preparation of ynones using potassium alkynyltrifluoroborates and its application to the synthesis of natural products
… straightforward procedure for the preparation of ynones from potassium alkynyltrifluoroborate salts and acyl chlorides or anhydrides has been developed. The one-pot reaction is advantageous in that it does not require exclusion of air or water, is operationally simple, has broad substrate scope, …
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Underutilized Dineophiles: Asymmetric Diels-Alder Reaction of Ynones and Ynoates with Oxygen-Functionalized Dienes
… an enantioselective Diels-Alder reaction using ynones and ynoates (Figure A1).The proposal is to use electron-rich dienes, similar to Danishefsky's diene, in order to generate 1,4-cyclohexadienes that have functional groups that can take part in further chemoselective transformations. The …