Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Yes-Associated Protein"”.
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Abundance and Localization of (Yes-associated protein) YAP in Prepubertal Bovine Mammary Tissue
… in dairy heifers. This pathway is mediated by yes-associated protein (YAP) and through downstream gene transcription activation, results in cell proliferation. Because YAP has never been identified in bovine mammary tissue, questions examined in this body of work mainly focused on the abundance …
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Functional Regulation of Yap By Aurora A Kinase In Triple-Negative Breast Cancer
<p>The Yes-associated protein (YAP) is an effector that transduces the output of the Hippo pathway to transcriptional modulation. Considering the role of YAP in cancers, this protein has emerged as a key node in malignancy development. In this study, we determined that Aurora A kinase acts as a …
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Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… mechanisms remain incompletely understood. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ or WWTR1), key players of the Hippo pathway, have been implicated in the liver fibrosis, but the HSC-specific functions of YAP and TAZ are largely unclear. Here …
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α7β1 integrin regulation of skeletal muscle growth in response to mechanical loading
… mechanical load, including upregulation of Yes-associated protein (YAP) content in skeletal muscle. The results from this study suggest that 1) the use of an automated computed program (SMASH) provides results that are comparable to manual measurement, 2) chronic mechanical loading elicits …
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Development of drug screening assays for identification of new molecules against pancreatic ductal adenocarcinoma
The yes-associated protein, YAP, is a transcriptional co-activator, able to regulate the expression level of a wide range of target genes. Despite deregulation of YAP has been associated with cancer etiology, no compounds are known to specifically modulate its functions. Here we identified an …
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Combinatorial Roles Of Skeletal Cell Yap And Taz In Bone Growth, Remodeling, And Repair
… of the paralogous transcriptional co-activators Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) in bone are controversial, with evidence for each either promoting or inhibiting osteogenesis in vitro. Here, we used in vivo mouse models of combinatorial …
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Specificity protein 1 induces the expression of angiomotin in response to IL-6/STAT3 activation to mediate YAP-dependent growth of breast cancer cells
… translocation of transcriptional co-activator yes associated protein (YAP), implicating IL-6 in the co-activation of several transcription factors such as the TEADs that trigger pro growth programs. While IL-6/STAT3 stimulation has been shown to increase YAP activity, the mechanism driving this …
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The inhibition of mammary epithelial cell growth by the long isoform of Angiomotin
… by the activities of the tumor suppressor protein kinases of the Hippo pathway. Canonically, Hippo protein kinases inhibit cellular growth through the phosphorylation and inactivation of the oncogenic transcriptional co-activator Yes-Associated Protein (YAP). This study defines an …
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The Role of Hippo Signalling in Merlin Null Tumours of the Nervous System
… The tumour suppressor Moesin-Ezrin-Radixin-Like Protein (Merlin) is deleted in 50-60% and 70% of meningiomas and schwannomas respectively. The Hippo pathway is an evolutionarily conserved pathway that has been shown to control tissue size by contactmediated growth inhibition. Previous studies …
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Evaluating the duration of increased milking frequency during early lactation for increased yield through lactation
… was a component of the Hippo signaling pathway, Yes-associated protein (YAP). Intensity of YAP staining in the cytoplasmic area of mammary epithelial cells (MEC) and number of YAP-positive stained nuclei located in the MEC were quantified for each of the images obtained. There was no effect of …
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Investigating the role of the Hippo pathway in epithelial-mesenchymal transition and drug resistance
… LATS1/2, which phosphorylate the transcriptional YES associated protein (YAP), promoting its nuclear exclusion and degradation. Excess YAP activity is oncogenic and is commonly observed in various human malignancies. Despite increased understanding of phenotypes associated with Hippo aberration …
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Multifunctional Regulators of Cardiac Disease and Development
… in development of endochondral bone. MEF2 proteins are widely known as essential regulators of development of various tissues such as striated muscle and brain. Based on expression patterns of Mef2 genes and skeletal defects present in Mef2c +/-; Mef2d +/- mice, I hypothesized that MEF2is …
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Defining mechanisms directing YAP/TAZ-mediated tumorigenesis
… cancers through the induced nuclear activity of yes-associated protein (YAP) and transcriptional co-activator with PDZ binding motif (TAZ) (YAP/TAZ). Uncontrolled nuclear YAP/TAZ activity evokes tumor-initiating properties in a range of epithelial-derived cancers, including oral and breast …
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α7β1 integrin regulation of skeletal muscle growth in response to mechanical stimulation
… for protection from stress and modulation of protein synthesis, both which may contribute to positive adaptations in skeletal muscle with mechanical stimulation. In Aim 2, WT and α7Tg mice were subjected to myotenectomy (MTE) of the gastrocnemius muscles and subsequent chronic mechanical …
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Determining Mechanisms by which Pathological Extracellular Matrix induces Ocular Hypertensive Phenotypes in Human Trabecular Meshwork Cells
… hTM cells via dysregulating β-catenin and Yes-associated protein (YAP)/Transcriptional co-activator with a PDZ-binding motif (TAZ) signaling pathways, hTM cells were seeded on CDMs/XCDMs for 24h. Where applicable, immunocytochemistry, RT-qPCR, Western blotting, enzymatic assays, …
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Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance
… functional retinoblastoma tumour suppressor (RB) protein pathway and associations to tamoxifen response. Furthermore, the expression of yes-associated protein (YAP1), reported to have both oncogenic and tumour suppressive functions, was investigated in breast cancer subgroups and related to …
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Age-associated alterations in head and neck cancer
… HNSCC is above the age of 65, and older age is associated with increased incidence, reduced survival, and limited treatment efficacy for HNSCC patients. Aging is associated with a multitude of cellular, molecular, and genomic processes that alter the function of tissues, including tumors, such …
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Biophysical profiling of YAP/TAZ dependent mechanical responses
Ageing manifests as architectural alterations at the tissue level and a decline in function. Biochemical and mechanical changes in the extracellular matrix (ECM) during ageing result in decreased cellular mechanotransduction. These changes negatively affect intra- and inter-cellular communication, …