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Showing 1 to 20 of 32 for “"Yersinia pestis"”.
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Carbon Catabolite Regulation of Yersinia pestis Pathogenesis
… with different aspects of the infectious cycle, Yersinia pestis evokes adaptive responses to concertedly regulate gene expression. The overall objective of this project was to ascertain the impact of carbon catabolite regulation upon Y. pestis pathogenesis. Specifically, this research encompassed …
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Dominant Suppression of Early Innate Immune Mechanisms by Yersinia pestis
… within a few hours of infection, but <italic>Yersinia pestis</italic> is strikingly different: the first 36 hours of infection are characterized by rapid bacterial replication in the lung without generating appreciable levels of proinflammatory cytokines/chemokines, histological changes in …
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In Vivo Gene Expression Profiling of the Plague Bacillus, Yersinia Pestis
Yersinia pestis, the causative agent of plague, can be transmitted by infected-flea bite or inhaled aerosol. Both routes of infection have a high mortality rate, and pneumonic infections of Yersinia pestis represent a significant fear as a tool of bioterrorism. Understanding the transcriptional …
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Purification, immunogenicity and protective potency of the F1 antigen from <i>Yersinia pestis</i>
<i>Yersinia pestis</i>, an organism endemic in much of the world, is the causative agent of pneumonic and bubonic plague. The disease is severe with a high mortality rate. Most plague vaccines are formalised whole cells, which give limited and short-lived immunity. An acellular vaccine could prove …
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Novel Virulence Factors in the Pathogenesis of Yersinia pestis Infection, the Causative Agent of Plague
Identification of new virulence factors in Yersinia pestis, the causative agent of plague, and understanding their molecular mechanisms during an infection process are necessary in designing a better vaccine or to formulate an appropriate therapeutic intervention. By using a high-throughput, …
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Functional expression and initial biochemical characterization of Yp-NhaP, cation-proton antiporter from Yersinia pestis
… antiporter from the dangerous human pathogen Yersinia pestis. We expressed Yp-NhaP in its functional form in the antiporter-deficient strain of E. coli, TO114. When assayed in inside-out sub-bacterial membrane vesicles, Yp-NhaP acted as an electroneutral cation/proton antiporter, exchanging …
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Enabling early stage drug discovery targeting high molecular mass penicillin-binding proteins in <i>Yersinia pestis</i>
Y. pestis is a G- facultative intracellular parasite, the causative agent of plague.The ability of this pathogen to acquire resistance, its potential as a biological weapon,high mortality caused by plague and its increasing prevalence, all highlight the need for investigating novel therapeutic …
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Estudo de cepas de Yersinia pestis isoladas durante epizootia no Foco da Chapada do Araripe, Pernambuco, Brasil
A Yersinia pestis, bactéria Gram-negativa da família Enterobacteriaceae, é uma espécie muito homogênea quando observada pelos métodos fenotípicos: apresenta apenas um sorotipo, um fagotipo e um biotipo subdividido em três biovars ou variedades geográficas. A peste é uma doença primária dos …
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Cellular and Genetic Basis for the Resistance of BALB /Cj and 129S1 /Svimj Mice to Yersinia Pestis
Yersinia pestis, the causative agent of plague, has been well studied at the molecular and genetic level, but little is known about the role that host genes play in combating this highly lethal pathogen. We challenged several inbred strains of mice with Y. pestis and found that BALB/cJ mice are …
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New virulence mechanisms in Yersinia pestis, the plague (Black Death)-causing bacterium: A re-emerging and bioterror pathogen
Yersinia pestis evolved from Y. pseudotuberculosis to become the causative agent of bubonic and pneumonic plague. Y. pestis is also a category A select agent based on its potential use as a biological weapon. Currently, there is no vaccine licensed in the United States for use against Y. pestis so …
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Climate Change and the Great Plague Pandemics of History: Causal Link between Global Climate Fluctuations and Yersinia Pestis Contagion?
The two great bubonic plague outbreaks of history, Justinian's Plague and the Black Death were responsible for the deaths of over one hundred million individuals across Eurasia and Africa. Both occurrences of the plague coincided with climatic shifts that are well documented by both literary and …
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Yersinia pestis CO92 mutant deleted for the genes encoding Braun lipoprotein and plasminogen activator protease: Characterization of a potential live-attenuated vaccine candidate
There is no FDA-approved vaccine against Yersinia pestis, the causative agent of bubonic and pneumonic plague. Since both humoral- and cell- mediated immunity are essential in providing protection to the host against plague, we developed a live-attenuated vaccine strain by deleting Braun …
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Induction of Long-Term Immune Responses to Protect Mice against Pneumonic Plague: Development and Testing of Novel Live-Attenuated Mutants of Yersinia pestis CO92
… the causative agent of the pneumonic plague, Yersinia pestis. Since both humoral and cell-mediated immunity are essential in providing protection against the plague, we developed three novel live-attenuated vaccine strains. These mutants were either deleted for genes encoding Braun lipoprotein …
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Evolutionary dynamics of the Yersinia enterocolitica complex
The genus Yersinia consists of a heterogeneous collection of organisms, comprising the highly pathogenic species Yersinia pestis, enteropathogens Yersinia pseudotuberculosis and Yersinia enterocolitica as well as environmental species. The evolutionary history of Y. pestis has been well documented, …
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Analysis Of Yscf And Associated Homologs And The Presence Of An Inflammatory Molecular Pattern
<p>Gram-negative pathogen, Yersinia pestis, expresses a type three secretion system to accomplish its virulence. The YscF needle protein provides a conduit of effectors from bacterium to eukaryote and is exposed to the host immune system. This thesis explores YscF and its associated needle homologs …
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Molecular design of nanoparticle-based delivery vehicles for pneumonic plague
… polymer-based adjuvant engineering, plague (<i>Yersinia pestis</i>) biology, and vaccines that confer protection against plague.</p> <p>Chapter 3 overviews the research objectives and the specific aims of this work.</p> <p>Chapter 4 describes the effect polymer chemistry has on uptake of …
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Novel antibiotics from DNA adenine methyltransferase inhibitors
… target for novel antibiotics. Dam from Yersinia pestis, the plague causing bacteria, was expressed and purified by nickel affinity chromatography. A plasmid containing the methylation sensitive restriction endonuclease dpnI gene was assembled. DpnI was expressed and purified by nickel …
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Pathosystems Biology: Computational Prediction and Analysis of Host-Pathogen Protein Interaction Networks
… <i>Francislla tularensis</i>, and <i>Yersinia pestis</i>. The second aim of the research presented here is the development of predictive models for identifying PPIs between host and pathogen proteins. We present two methods: (i) a domain-based approach that uses frequency of …
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