Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"Yellow fever"”.
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The Great Pestilence: Yellow Fever in Portsmouth, Virginia, 1855
… Virginia was devastated by an epidemic of yellow fever. Most citizens fled. Of those who remained, most became infected and a thousand died. The municipal government collapsed. In their place, a small organization known as the Portsmouth Relief Association assumed responsibility for …
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Yellow Fever: Role of Heterologous Flavivirus Immunity on Urban Emergence
During the recent yellow fever (YF) epidemics in Brazil, human cases were attributed only to spillover infections via sylvatic mosquito transmission. Despite YF virus (YFV) transmission in major urban centers with insufficient vaccination coverage and abundant populations of the domestic vector, …
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Immunogenicity and toxicity of yellow fever vaccines : a systematic review
BACKGROUND Yellow fever (YF) is a non-contagious, mosquito borne haemorrhagic fever caused by a single-strand RNA flaviviruses. YF is endemic in the tropics primarily in South America and Africa although the vectors are present in Asia, Europe, Pacific and Middle East. Human beings serve as …
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Characterization of a recombinant chimeric yellow fever 17D vaccine - dengue-4 virus
… vaccine viruses based on a backbone of the yellow fever virus 17D (YFV-17D) vaccine virus with the structural components premembrane and envelope (prME) of a corresponding wild-type DENV. This thesis investigated the impact of viral chimerization on a YFV-17D infectious clone where the 17D …
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Population Structure of Yellow Fever Virus: Influence of Viral Diversity on Vaccine Attenuation
Yellow fever virus (YFV) is the prototype of all arthropod-borne viruses, the study of which encompasses some of the landmark paradigm shifts in modern vaccinology. Recently, studies on the lifecycle of RNA viruses have indicated that population structure of these viruses is in many cases complex, …
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Effects of fractional dose yellow fever vaccination: a systematic review and meta-analysis
Persistent yellow fever endemicity and continued outbreaks have continued to increase vaccine demand, while straining global vaccine supply. Fractional dose vaccination is being considered as a dose-sparing strategy to mitigate current global vaccine shortages. This study therefore assessed the …
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Toxicological Analysis of Tacrines and Verapamil on the Yellow Fever Mosquito, Aedes aegypti
Mosquitoes affect human health worldwide as a result of their ability to vector multiple diseases. Mosquitocide resistance is a serious public health challenge that warrants the development of improved chemical control strategies for mosquitoes. Previous studies demonstrate the mosquito blood-brain …
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Investigation of the interplay of yellow fever virus structural protein epitopes and genetic diversity
Yellow fever virus (YFV), a mosquito-borne flavivirus, is responsible for the disease yellow fever (YF), which is characterized by hemorrhagic fever and multiorgan failure. The disease is prevented by a live attenuated vaccine (LAV), strain 17D, that was derived from serial passage of the wild type …
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From Houston to Memphis: the Kezia Payne Depelchin letters and the yellow fever epidemic of 1878
… individual nurse's experience during the Memphis yellow fever epidemic of 1878 was examined to explore nursing as it was evolving from a pre-professional to professional status. Nursing's contributions to the framework of care established as a response to the yellow fever public health crisis were …
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Molecular characterization and functional analysis of cytochrome P450 genes in the yellow fever mosquito Aedes aegypti (Diptera: Culicidae)
… commonly used pyrethroid insecticides in the yellow fever mosquito (Aedes aegypti). Our genome-wide analysis of revealed 159 P450 genes that can be classified into 18 families and 63 subfamilies. These genes are distributed in four clans, including 11 genes in the CYP2 clan, 80 in the CYP3 …
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Investigating the role of non-structural genes in the genotype and phenotype of yellow fever vaccine strain 17D
The first yellow fever outbreak was recorded in 1648 in the Yucatan Peninsula. Almost 300 years later, a live-attenuated vaccine against yellow fever virus, the causative agent of yellow fever, was successfully derived by serial passage of Asibi virus 176 times in chick and mouse embryo tissue. The …
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Historical and Contemporary Variables Affecting the Range and Distribution of Aedes aegypti, The Yellow Fever Mosquito, in The United States
… aegypti, the primary mosquito vector of the yellow fever virus, threatens global health by passing on this virus, as well as chikungunya, dengue, and Zika viruses. Through its natural tendency to live in highly urban areas and bite human hosts; understanding the factors that affect the …
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From Dago to White: The Story of Sicilian Ethnic Evolution in New Orleans Amidst the Yellow Fever Epidemic of 1905
… immigrants faced the threat of disease.</p> <p>Yellow fever was a recurring threat to the city of New Orleans, striking the city seemingly at random. The 1905 yellow fever epidemic dealt a heavy blow to this ethnic community; an unpredictable killer that tended to hit newcomers the hardest. This …
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The early zygotic genes and microRNAs in the yellow fever mosquito Aedes aegypti and the Asian malaria mosquito Anopheles stephensi
… vectors for multiple diseases like malaria, yellow fever and dengue fever. To manipulate gene expression in mosquito and spread desired genes among natural population for vector control, a thorough understanding of mosquito development and gene regulation is critical. Early embryogenesis is a …
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Genetic modification of the homomorphic sex chromosomes in the yellow fever mosquito Aedes aegypti provides novel insights and tools for biocontrol
… largely responsible for the spread of Zika, yellow fever, chikungunya, and dengue viruses. Current methods of preventing the spread of arboviral diseases rely primarily on population control of the mosquito vector. These practices are insufficient as millions of arboviral infections still …
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Study of viruses isolated in the tropics
… in Africa. Investigations of the epidemiology of yellow fever and of new methods of vaccinating against it are described in the first series of papers. These yellow fever studies led incidentally to the recovery of several previously unknown viruses. Two of these which were called Zika virus and …
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Methods for the Genetic Stabilization of Reporter Flaviviruses and their Applications
… was shown effective for stabilizing Zika and yellow fever viruses to ten passages in cell culture. The effectiveness of the second method to likewise stabilize reporter flaviviruses was demonstrated with Zika, yellow fever, dengue serotypes 1-4, Japanese encephalitis, and West Nile viruses. …
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Methods for the Genetic Stabilization of Reporter Flaviviruses and their Applications
… was shown effective for stabilizing Zika and yellow fever viruses to ten passages in cell culture. The effectiveness of the second method to likewise stabilize reporter flaviviruses was demonstrated with Zika, yellow fever, dengue serotypes 1-4, Japanese encephalitis, and West Nile viruses. …
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