Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"Yellow Fever Virus"”.
-
Population Structure of Yellow Fever Virus: Influence of Viral Diversity on Vaccine Attenuation
Yellow fever virus (YFV) is the prototype of all arthropod-borne viruses, the study of which encompasses some of the landmark paradigm shifts in modern vaccinology. Recently, studies on the lifecycle of RNA viruses have indicated that population structure of these viruses is in many cases complex, …
-
Investigation of the interplay of yellow fever virus structural protein epitopes and genetic diversity
Yellow fever virus (YFV), a mosquito-borne flavivirus, is responsible for the disease yellow fever (YF), which is characterized by hemorrhagic fever and multiorgan failure. The disease is prevented by a live attenuated vaccine (LAV), strain 17D, that was derived from serial passage of the wild type …
-
Investigating the role of non-structural genes in the genotype and phenotype of yellow fever vaccine strain 17D
The first yellow fever outbreak was recorded in 1648 in the Yucatan Peninsula. Almost 300 years later, a live-attenuated vaccine against yellow fever virus, the causative agent of yellow fever, was successfully derived by serial passage of Asibi virus 176 times in chick and mouse embryo tissue. The …
-
Contributions of Structural and Non-structural Genes to the Attenuation of the 17D Vaccine
Live-attenuated 17D vaccine, developed to control Yellow Fever virus (YFV), was derived by serial passage of wild-type Asibi strain 176 times in mouse and chicken tissues. Despite the derivation of 17D over 75 years ago, the mechanism of attenuation is still poorly understood. The genomes of …
-
Characterization of the molecular and biological determinants of viral dissemination from the mosquito midgut: Yellow feber virus in Aedes aegypti
In order for a mosquito-borne virus to be transmitted from an infected mosquito to a vertebrate host, virus must disseminate from the mosquito midgut- the initial site of infection following uptake of an infectious bloodmeal- to infect the salivary glands and enter the saliva. The genetic …
-
Characterization of a recombinant chimeric yellow fever 17D vaccine - dengue-4 virus
… by four genetically and serologically related virus termed dengue virus-1 to dengue virus-4 (DENV-1 to DENV-4) There are currently no licensed therapeutics, but there is a recently licensed recombinant live attenuated tetravalent vaccine, termed Dengvaxia™ by Sanofi Pasteur, available in some …
-
Characterization of Host Factors and Anti-viral Compounds for Diverse Mosquito-borne Flaviviruses
… therapeutics requires discovery of novel host-virus interactions as well as an informed anti-viral discovery pipeline. We used a genome-scale RNAi-based screen followed by a chemical screen of FDA-approved therapeutics to identify scores of novel dengue virus (DENV) human host dependency …
-
Historical and Contemporary Variables Affecting the Range and Distribution of Aedes aegypti, The Yellow Fever Mosquito, in The United States
… aegypti, the primary mosquito vector of the yellow fever virus, threatens global health by passing on this virus, as well as chikungunya, dengue, and Zika viruses. Through its natural tendency to live in highly urban areas and bite human hosts; understanding the factors that affect the …
-
Human Antibody Response to Flaviviruses and SARS-Coronavirus-2
… outbreaks. These include tick-borne encephalitis virus (TBEV), Powassan virus (POWV), Zika virus (ZIKV) and severe acute respiratory syndrome coronavirus (SARS-CoV-2). The first part of this thesis focuses on encephalitis-causing tick-borne flaviviruses, specifically TBEV and POWV. Both TBEV and …
-
Evaluation of arthropod-borne virus recombination potential and phenotype: In vitro and in vivo analysis of flavivirus and alphavirus model systems
… whereby positive sense single stranded RNA viruses exchange segments of genetic information. Recent phylogenetic analyses of naturally occurring recombinant flaviviruses have raised concerns regarding the potential for the emergence of virulent recombinants either post-vaccination or …
-
Usutu Virus: An Emerging Arbovirus Threat
Mosquito-borne viruses, such as dengue virus (DENV), Zika virus (ZIKV), chikungunya virus (CHIKV), yellow fever virus (YFV), Japanese encephalitis virus (JEV), and West Nile virus (WNV) are major threats to global public health resulting in millions of infections and hundreds of thousands of deaths …
-
DENVax live attenuated chimeric dengue vaccine
Dengue viruses are endemic in regions inhabited by roughly one half of the world’s population and can cause symptoms ranging from a headache and fever to even death. There is no vaccine to prevent infection by dengue viruses and the only current protection and prevention is mosquito control. The …
-
Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity
… inhibits replication of bovine viral diarrhea virus, a ruminant pestivirus of the family <em>Flaviviridae</em>, but has no appreciable effect on VSV, a rhabdovirus. We have also shown that TRIM56 forms a complex with the Toll-like receptor-3 (TLR3) adaptor, TRIF, via its C-terminal residues …
-
Characterization of a novel bioluminescent reporter protein for the non-invasive preclinical imaging of viral infection
RNA viruses pose significant public health concerns due to their high mutation rates. This ability enables the rapid evolution of endemic viruses and the emergence of new strains with enhanced virulence. Many RNA viruses originate from animals, facilitating zoonotic transmission and the potential …
-
Characterization of the Antiviral Effector IFI6
… establish an antiviral state in the cell. Flaviviruses such as dengue virus, Zika virus, and West Nile virus rely intimately on host pathways for completing a replication cycle, and have developed strategies to overcome the inhibitory effect of the innate immune response. To identify host …
-
Characterization of Host Factors Affecting Viral Entry
The file named "RINKENBERGER-DISSERTATION-2019.pdf" is the primary dissertation file. Two (2) supplemental video files are also available and may be viewed individually.