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Showing 1 to 3 of 3 for “"Yck2"”.
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Palmitoylation and the yeast casein kinase yck2
… Saccharomyces cerevisiae, the casein kinase Yck2 is palmitoylated twice at its two C-terminal palmitoyl-accepting cysteine residues, by the palmitoyl-transferring enzyme Akr1. Once palmitoylated, Yck2 traffics through the well characterized secretory pathway to the plasma membrane where it …
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Search For The Functions That Mediate Protein Palmitoylation And Depalmitoylation
… decreases the amount of palmitoylated Yck2 in palmitoylation assays. Results presented here show that <i>BCH2</i> overexpression disrupts exomer complex function, which underlies the defect in palmitoylation of Yck2. A model proposed here suggests that upon proper function of the exomer …
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Exploiting Chemical Libraries to Identify and Characterize Novel Bioactives with Efficacy Against Pathogenic Candida Species
… optimize inhibitors of the fungal casein kinase, Yck2. An existing Yck2 inhibitor, GW, was rationally modified to generate substituted analogues and imidazo[1,2-a]pyridine bio-isosters to improve metabolic stability. I identified four analogues with improved stability that retained anti-Candida …