Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Yap1"”.
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Yap1 Expression Predicts Sensitivity to Dual Akt/P70S6K Inhibition In Ovarian and Uterine Malignancies
… (IC50 ≥ 5 µM) cell lines. RPPA identified YAP1 as a candidate marker to predict cell lines that were most sensitive to MSC2363318A (R=0.675, p=0.0015). After establishment of a bevacizumab resistant endothelial cell line, RF-24, we demonstrate that resensitization to bevacizumab occurs with …
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HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation
Human papillomaviruses (HPV) typically cause chronic infections by modulating homeostasis of infected basal cell to ensure persistence. Using FUCCI and cell-cell competition assays, we established the role of two common viral targets of low-risk and high-risk E6 proteins, E6AP and NHERF1, on the …
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Estudio de los coactivadores transcripcionales TAZ y YAP1 en el sarcoma de Ewing: Implicación en la progresión tumoral e interacción funcional con la proteína de fusión EWS-FLI1
… los dos efectores finales de la vía Hippo, TAZ y YAP1, en las capacidades proliferativas e invasivas de la célula tumoral del sarcoma de Ewing (SE), contribuyendo a ampliar el conocimiento del papel de la vía Hippo en esta enfermedad. Además, se propone un posible mecanismo de desregulación de …
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Microarray data analysis methods and their applications to gene expression data analysis for Saccharomyces cerevisiae under oxidative stress
… responses is still not clearly understood. The Yap1 transcription factor is crucial for the normal response to a variety of stress conditions including oxidative stress. Previous studies on Yap1 regulation started to measure gene expression profile at least 20 minutes after the induction of …
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Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance
… the expression of yes-associated protein (YAP1), reported to have both oncogenic and tumour suppressive functions, was investigated in breast cancer subgroups and related to tamoxifen response. Two of the key processes in malignant behaviour, proliferation and migration, have previously …
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MUC13 Enhances Colorectal Cancer Metastasis
… able to find changes in transcription factor YAP1 and YAP1 and β-catenin, which are known to play vital roles in cellular development. In recent studies YAP1 and β-catenin have been shown to form a complex that promotes tumor cell survival and increased tumorigenesis. High MUC13 expression …
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Genetic modeling of the Hippo pathway in hematopoietic stem cells
… possible in ES cells. In Article II we studied YAP1, the downstream effector in the Hippo pathway. We created a transgenic model with inducible YAP1 expression exclusively within the hematopoietic system using the blastocyst complementation approach developed in article I. When investigating the …
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Identification of Oncogenic KRAS-Associated Vulnerabilities in Non-Small Cell Lung Cancer
… addiction to XPO1-dependent nuclear export via YAP1 activation as a consequence of previously unappreciated co-occurring loss-of-function mutations in FSTL5 and mutations in Hippo pathway. The intrinsic resistance was reversed by coadministration of YAP1/TEAD inhibitor. Thus, our study suggests …
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Heparan Sulfate Proteoglycans in Pancreatic Ductal Adenocarcinoma (PDAC)
… challenge. Mechanistically, we revealed that the YAP1-SDC1 axis was the major driving force for bypassing KRAS* dependency to sustain nutrient salvage machinery, tumor maintenance and growth. Specifically, YAP1 transcriptionally regulate ARF6 GAPs in an indirect manner to promote SDC1 localization …
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The effects of elevated mitochondrial hydrogen peroxide in S. cerevisiae : a physiological role for cytochrome c peroxidase
… all regulated through the transcription factor YAP1, showed reduced activity in the x ccp1 strain compared to the isogenic wild-type strain, possibly explaining the increased sensitivity of x ccp1 cells to H 2 O 2 . The x ccp1 strain also showed decreased phosphatase and increased kinase …
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Molecular mechanisms of acquired gemcitabine resistance in pancreatic cancer
… and caspase-8 activation possibly via binding to YAP1. The finding of demethylation of the 14-3-3σ gene in gemcitabine resistant cells led to a hypothesis that other genes may also be changed epigenetically following gemcitabine selection. By RRBS (Reduced Representation Bisulfite Sequencing) …
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Specificity protein 1 induces the expression of angiomotin in response to IL-6/STAT3 activation to mediate YAP-dependent growth of breast cancer cells
… by STAT3. This work connects the activation of YAP1 by IL-6/STAT3 through the elevation of Amot expression by Sp1. Taken together, this explains a new avenue whereby breast cancer cells acquire enhanced oncogenic properties in response to inflammatory signaling.
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Novel Diagnostics and Therapeutic Approaches for Supratentorial Ependymoma
… a fusion of C11orf95 and RELA, or less commonly, YAP1. The C11orf95-RELA fusion protein acts as a potent driver of oncogenesis in mouse models, and patients with this form of the disease have a particularly poor prognosis. Here, I describe research to develop a new diagnostic antibody for …
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EPIGENETIC MODIFICATIONS REGULATING LIVER HOMEOSTASIS AND TUMORIGENESIS
… among these mutations were found MYC, YAP1, PTEN and S33A β-Catenin mutation.
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Histone Lysine Demethylase KDM4A as a Therapeutic Target for Small Cell Lung Cancer
… factors including ASCL1, NEUROD1, POU2F3, or YAP1. The expression of various MYC family members leads to further inter-tumor heterogeneity. Despite this heterogeneity in SCLC, the current treatment for SCLC is lineage-transcription-factor-subtype agnostic. Although most patients are initially …
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ING1 Impacts Ovarian Cancer by Altering EMT
… of transcription factors and their co-factor, YAP1, to further influence gene expression. Lastly, we found that high ING1 protein expression was associated with p16 and ARID1A levels and predicted better DSS in ovarian clear cell carcinoma (OCCC). Our data also suggested that high ING1/low …
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Identification and functional characterisation of gene fusions in human cancer cell lines
… of novel gene fusions. A gene fusions in YAP1-MAML2 represents a particularly interesting finding showing functionality across multiple distinct cancer types. Altogether, in my thesis, I demonstrate that innovative computational approaches leveraging new datasets can enable us to elucidate …
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The role of microRNA-194 and microRNA-375 in prostate cancer metastasis
… growth of prostate cancer cells. I identified YAP1, a transcriptional coactivator and a potent oncogene, as a direct and biological relevant target of miR-375. Additionally, I demonstrated that miR-375 was under the direct transcriptional control of EMT-promoting factor, ZEB1. Collectively, …
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Efeitos da apomorfina e de um produto derivado de sua autoxidação em diferentes modelos biológicos
… catalase (ctt1), superóxido dismutase (sod1) e yap1 foram as mais sensíveis. APO protegeu as linhagens de S. cerevisiae contra danos oxidativos induzidos por concentrações altas de H2O2 e t-BOOH, enquanto que 8-OASQ aumentou os efeitos pró-oxidantes e induziu respostas adaptativas para aqueles …
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Stress Fiber Formation and Migration Are Novel PGR-Dependent Pathways Initiated in the Granulosa Cells of the Ovulating Follicle
… observed activation of mechanoresponsive element Yap1 at the follicle base and identified a gain in migratory capacity in granulosa cells. Concurrently, the basal granulosa cell layer thickened immediately prior to ovulation. Each of these events was PGR-dependent. This data demonstrates granulosa …
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