Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Yap and Taz"”.
-
YAP and TAZ have Functionally Redundant Roles in Uveal Melanoma
… main downstream effectors are MAPK signaling and the transcriptional activator YAP. Recent zebrafish work established the importance of YAP and de-emphasized the role of MAPK in UM. Here we show that deletion of yap has no significant effect on the incidence, or kinetics, of GNAQQ209L-driven …
-
Yap and Taz Are Required For Neural Crest-Derived Cardiovascular Development
… birth defect, occurring in ~1/100 newborns, and are a leading cause of early infant death. Cardiac neural crest cells (NCCs) are a migratory and multipotent cell population known to aid in the development of the cardiac outflow tract (OFT), valves, and interventricular septum, during …
-
Phenotypic screening and AI uncovers modulators of YAP and TAZ activity in glioblastoma
Glioblastoma (GBM) is the most common and advanced primary malignant brain tumour accounting for almost 50% of all primary tumour diagnoses; this is also the most lethal brain tumour with an average survival between 14-16 months. The Stupp protocol, representing the standard of care, was introduced …
-
Combinatorial Roles Of Skeletal Cell Yap And Taz In Bone Growth, Remodeling, And Repair
During bone growth, remodeling, and fracture repair, skeletal lineage cell responses require the coordinated activation of multiple transcriptional programs. As defective genetic regulation of bone formation leads to both developmental and metabolic skeletal diseases, identifying and characterizing …
-
Vinexin regulates autophagy through YAP/TAZ: implications for health and disease
… via lysosomal degradation of proteins and organelles. Dysfunctional autophagy occurs in numerous human pathologies, including neurodegeneration and cancer. Vinexin (encoded by SORBS3) is a physiologically important adaptor protein for two main reasons: 1. SORSB3 mRNA expression …
-
Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… tissue, which disrupts the hepatic architecture and causes liver dysfunction. Hepatic stellate cells (HSCs) play a major role in hepatic fibrosis. However, the molecular mechanisms remain incompletely understood. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif …
-
Analysis of Hippo pathway signalling in schwannoma and meningioma
… on two tumours of the nervous system, schwannoma and meningioma. A large group of schwannomas and meningiomas display the inactivation of the NF2 gene. The NF2 gene codes for the tumour suppressor protein Merlin and its loss is associated with a multitude of pro-tumourigenic mechanisms leading to …
-
The Role of Hippo Signalling in Merlin Null Tumours of the Nervous System
Meningiomas and schwannomas are mostly benign tumours of the nervous system that currently have no clinically approved treatments apart from surgical resection. The tumour suppressor Moesin-Ezrin-Radixin-Like Protein (Merlin) is deleted in 50-60% and 70% of meningiomas and schwannomas respectively. …
-
YAP/TAZ REGULATES ALVEOLAR REGENERATION AND RESOLUTION OF LUNG INFLAMMATION
… these insults to rebuild the epithelial barrier and restore pulmonary functions. Here, we show that sublethal infection of mice with Streptococcus pneumonia, the most common pathogen of community-acquired pneumonia, led to exclusive damage in lung alveoli, followed by alveolar epithelial …
-
UNRAVELING TAZ REGULATION IN BREAST CANCER BY CRISPR SCREENING
YAP and TAZ are transcriptional coactivators belonging to the Hippo signaling pathway. Their activity is regulated by a complex network of upstream signals. As consequence, they orchestrate a wide spectrum of downstream cellular responses. In physiological conditions, a precisely balanced …
-
The Role of YAP/TAZ in von Willebrand Factor Gene Expression
von Willebrand Factor (VWF) is a large multimeric glycoprotein with important procoagulant roles in the circulation, including mediating platelet adhesion at sites of vascular injury and stabilizing Factor VIII in the plasma. VWF expression and activity is critically regulated to protect against …
-
Biophysical profiling of YAP/TAZ dependent mechanical responses
… as architectural alterations at the tissue level and a decline in function. Biochemical and mechanical changes in the extracellular matrix (ECM) during ageing result in decreased cellular mechanotransduction. These changes negatively affect intra- and inter-cellular communication, homeostasis, and …