Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Yap activation"”.
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HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation
… E6AP-/- cells. Amongst the pathways identified, YAP target genes were activated by either E6 expression or E6AP depletion. This is confirmed by the analysis of YAP expression pattern in both monolayer cell culture and HPV-infected lesions. As the conserved binding partner of Alpha group HPV E6 …
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Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules
… miRNAs, revealing an involvement of the Hippo-YAP pathway in their action. We found that all the investigated miRNAs activated YAP-mediated transcription, nuclear localization of active YAP and increased expression of YAP responsive genes. Of notice, miR-199a-3p, one of the most effective …
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Small-Molecule Activation of Yap for Inner-Ear Regeneration – and Beyond
… inhibitor of Lats kinases, the compound causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids. The compound promotes the initial stages of the proliferative regeneration of hair cells, a process thought …