Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"YY1"”.
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Survivin: Regulation by YY1 and Role in Pancreatic Cancer Combination Therapy
… regulator of survivin called Yin Yang 1 (YY1). YY1 is a transcription factor that has been observed to activate some gene promoters and repress others, and it is gaining increasing interest as a target of cancer therapy. Our work shows for the first time that YY1 is a repressor of survivin …
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Roles of CTCF and YY1 in T Cell Receptor Gene Rearrangement And T Cell Development
… segments. Finally, we investigated the role of YY1 in early T cell development by conditionally deleting YY1 in developing thymocytes. We found that early ablation of YY1 caused severe developmental defects in the DN compartment due to a dramatic increase in DN thymocyte apoptosis. Furthermore, …
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EPIGENETIC AND FUNCTIONAL ASSESSMENT OF ENHANCEROPATHIES ACROSS HUMAN MODELS: FOCUS ON GABRIELE-DE VRIES SYNDROME
Yin Yang 1 (YY1) is a ubiquitous zinc finger transcription factor (TF) that occupies active enhancers and promoters contributing to physical interactions between these regions via DNA looping. Increasing evidence shows that disruption of non-coding regions such as enhancers is prevalent across …
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G4-RESOLVASE 1 TIGHTLY BINDS AND CATALYTICALLY UNWINDS UNIMOLECULAR G-QUADRUPLEX STRUCTURES WITH IMPLICATIONS FOR GENE TRANSCRIPTION AND TELOMERE BIOLOGY
… G4-structures in the promoter of the Yin Yang 1 (YY1) gene and demonstrate that these structures have an inhibitory effect on reporter assay expression. We also discovered that G4R1 directly binds and unwinds G4-structures in the YY1 promoter, subsequently enhancing reporter expression. …
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Polyphosphate Modification of Human Proteins and a New Mechanism for Regulating Super-Enhancer Activity
… coactivator BRD4, and the transcription factor YY1. These modifications disrupted their capacity for phase separation, reduced MED1 and BRD4 expression and impaired YY1 nuclear localization. In addition, polyP inhibited YY1 dimer formation and disrupted YY1-mediated DNA looping, ultimately …
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Charakterisierung des 5-HT<sub>3B</sub>-Promotors der Ratte vor dem Hintergrund eines mit Chemotherapie-induziertem Erbrechen assoziierten Polymorphismus
… USF1 (Upstream Stimulatory Factor 1), YY1 (Ying Yang 1) und NF-1 (Nuclear Factor-1). USF1 bindet an einer E-Box zwischen -183 bis -178 bp vor dem Startkodon. Eine Mutation der USF1-Bindungssequenz führte im -258 bp-Promotorfragment zu einer Abnahme der Aktivität um 55%. Die …
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Longitudinal gene networks, canonical pathways and functional analysis of microarray data from Longissimus thoracis et lumborum muscle samples of early-weaned Angus steers
… analysis was performed. As a result, Yin Yang 1 (YY1) was the transcription regulator that affected the greatest number of molecules (126 genes). Within these affected genes with direct and indirect connection to YY1 gene, Insulin Growth Factor Binding Protein 5 (IGFBP5), Signal transducer and …
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Transcriptional regulation and genome structure
… and characterization of the transcription factor YY1 as a factor that can structure enhancer-promoter loops. Through a combination of genetics, genomics, and biochemistry, my studies have helped to identify insulated neighborhood structures, shown the importance of these structures in the control …
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Identification of host factors required for cytosol entry by Shigella flexneri: Results of a genome-wide CRISPR/Cas9 screen
… I showed that the transcriptional regulator YY1 is also required for cytosol entry and replication. Both KHDRBS1 and YY1 are likely to act indirectly in *Shigella* infection by their impact on host processes. The adaptor protein (AP)-3 subunit AP3M2 is involved in protein sorting in the …
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DIRECT REPROGRAMMING OF HUMAN FIBROBLASTS INTO CARDIOMYOCYTES
… regulators and found two new factors, SALL4 and YY1 significantly enhanced reprogramming efficiency in human dermal fibroblasts (HDFs) when working together with GATA4, MEF2C, TBX5, HAND2 and MYOCD (5F). HDFs-generated iCMs exhibited cardiac-like action potential and spontaneously contractility …
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Genome organization in transcriptional regulation
… in this thesis identify the transcription factor YY1 as a general structural regulator of enhancer-promoter loops (Weintraub et al., 2017). In recent years, the study of biomolecular condensates has led to a dramatic shift in our understanding of the mechanisms contributing to transcriptional …
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Gene expression changes during mammalian male meiotic initiation
… at the proximal promoters, we identified YY1 as a potential regulator of the genes whose expression decreases at meiotic initiation. In taking a descriptive experimental approach we identified novel gene expression changes during meiotic initiation, which furthers our understanding of germ …
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Alteration of differentiation and growth of normal human epidermal keratinocytes by benzo[a]pyrene and arsenic
… acid- and interferon-inducible protein, and YY1-associated factor-2. Arsenic altered the expression of genes involved in cell cycle checkpoint regulation. These genes include; MAX binding protein, RAD50, retinoblastoma-1, retinoblastoma-binding protein-1, and transforming growth factor …
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The Cellular Mirna, Mir-190, is Upregulated in Type I Ebv Latency by Ebers and Modulates Cellular Mrnas involved in Cell Survival and Viral Reactivation
… promoter reporters that lacked YinYang1 (YY1) and Nuclear factor-κB (NF-kB) binding motifs. In the presence of EBERs, promoters with these deleted binding motifs had lowered activation compared to the full miR-190/TLN2 promoter. This work describes a mechanism by which EBERs upregulate a …
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Stress-induced transcription factors and their role in RNA disruption in ovarian cancer cells
… of interest were chosen: TFEB, TFE3, Nrf2, and YY1. Cytoplasmic and nuclear extracts were then made from A2780 cells after treatment with doxorubicin, docetaxel, thapsigargin, and starvation for 0, 2, 16, or 24 hours. The amount of RNA disruption was then assessed by RDA 72 hours after treatment …
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Influence of prepartum nutrition on cow performance and subsequent calf performance, glucose tolerance, carcass characteristics, efficiency, and gene expression
… (P ≤ 0.01) for expression of SLC2A4, YY1, and MYH7. In conclusion, prepartum DDGS supplementation improved cow BW and BCS but did not alter milk production, subsequent reproduction, or subsequent calf performance or carcass characteristics. Feeding cows 125% of TDN requirement during …