Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"YTHDF2"”.
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Role of m<sup>6</sup>A RNA "reader" YTHDF2 in Mammalian Germ Cells and Early Embryo Development
… with high affinity, YTH-domain family protein 2 (YTHDF2). However, little is known about the role of m6A-RNA modification in vivo and YTHDF2 mechanism of regulation. To have a comprehensive understanding of m6A-RNA role in vivo we generated a state of the art complex tag and conditional allele of …
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Uncovering the Roles of Human C2H2-Zinc Finger Protein ZNF121 in Gene Regulation
… proteins YTH-domain-containing family protein 2 (YTHDF2). However, YTHDF2 has a relatively weak affinity for its mRNA targets. RNA-binding proteins (RBPs) bind transcripts to exert regulatory effects, and many DNA-binding C2H2-zinc finger proteins (ZFPs) have recently been shown to be RBPs with …
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Computational Analysis of Transcriptional Regulation
… transcriptional noise. Maternally-supplied YTHDF2 is essential for degradation of m6A-modified transcripts during the maternal-to-zygotic transition (MZT) early in mammalian embryogenesis. YTHDF2 targets increase in abundance in its absence. Using scRNA-seq data generated from control and …
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Role of N6-Methyladenosine (m6A) epitranscriptomic mechanisms in manganese-induced astrocyte inflammation
… and eraser regulatory tiers, in which we find YTHDF2, the m6A decay-promoting reader, decreases upon Mn exposure, while ALKBH5 and FTO, two m6A demethylases, are increased. Our deeper inquiry into YTHDF2 function revealed that it could act as a potential anti-inflammatory protein in Mn exposed …
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Genetic screens of RNA binding proteins identify a role for N6-methyladenosine in promoting B cell differentiation
… demonstrated a role for the m6A binding protein Ythdf2 in promoting B cell terminal differentiation, independently of a role in proliferation or survival. In the future, I hope to validate an in vivo role for Ythdf2; and further elucidate the in vitro molecular mechanism.
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Role of PBRM1 in regulation of the HIF pathway
… is important for recognition of HIF1α mRNA by YTHDF2 and able to interact with mRNA suggesting a link between this chromatin remodeling complex and mRNA processing. Additionally, PBRM1 contributes to the hypoxia induced expression of HK2 and PHD2 genes, possibly by interacting with HIF1 at HRE …