Global ETD Search
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Showing 1 to 9 of 9 for “"YKL-40"”.
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REGULATION OF YKL-40 IN STERILE INFLAMMATION AND ITS ROLE IN GLIOBLASTOMA IN VIVO
<p>YKL-40 is a secreted glycoprotein, which is a shared biomarker of chronic inflammation and oncogenic transformation. Indeed, YKL-40 expression is up-regulated in many diseases including multiple sclerosis, Alzheimer disease, viral encephalitis, HIV-associated dementia, brain infarction, and …
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Novel mechanism in astrocyte gene regulation and function
… elusive. Here, we show for the first time that YKL-40 is a novel target gene of NFI-X in astrocytes and controls their migration. In addition, we report that YKL-40 expression is activated during mouse brain development and also during the differentiation of neural progenitors into astrocytes in …
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Analysis of NFI-X3 and STAT3 Interaction and Its Functions
YKL-40 is a secreted protein that is highly up-regulated in malignant glioblastoma (GBM). Its expression is correlated with the invasive nature of GBMs and poor diagnosis of patients (Nigro et al., 2005). Previous research has shown that in astrocytes and GBM cells, YKL-40 expression is regulated …
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Identification of Novel Fluid Biomarkers for Alzheimer's Disease
… that distinguished CDR 0 from CDR>0: tau, YKL-40, NCAM) and CDR 1 from CDR<1: tau, chromogranin-A, carnosinase-I). Plasma levels of the most promising marker, YKL-40, were also found to be increased in CDR 0.5 and 1 groups and to correlate with CSF levels. Importantly, the CSF YKL-40/A├ó42 …
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Anti-inflammatory and chondroprotective role of tart cherry polyphenols in SW1353 human chondrocytes
… as indicated by decreases in glycoprotein-39 (YKL-40) levels. TCP appeared to have no significant effect on total protein expression of the pro-inflammatory transcription factor, necrosis factor kappa B (NF-κB), or the matrix degrading enzyme, matrix metalloproteinase-3 (MMP-3). In conclusion, …
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The effect of freeze-dried whole blueberry powder on joint flexibility, mobility, and serum biomarkers of cartilage metabolism in symptomatic knee osteoarthritis
… group (treatment; n=33) consumed a total of 40 grams of freeze dried whole blueberry powder daily (packaged in 20 gram pouches to be consumed twice a day, to be equivalent to two servings of fresh blueberries) for 16 weeks. A control group (n=30) consumed 40 grams of a powder daily for 16 …
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Pathophysiological Mechanisms and Diagnostic Markers in Alzheimer’s Disease
… (neurogranin) and microglial activation (YKL-40) in healthy controls, patients with mild cognitive impairment and patients with common dementias. We found the former to be selectively increased in AD dementia, whereas the latter was increased in both AD and frontotemporal dementia. …
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THE ROLE OF EXTRACELLULAR VESICLES IN HEART DISEASES
… Factor C – VEGF-C; Chitinase-3-like Protein 1 – YKL-40; Procollagen Type I N-Terminal Propeptide – PINP) were quantified in plasma of the cohorts using ELISA. THP-1 cells, an immortalized human monocytic cell line, were employed in vitro to assess the molecular effects, specifically from an …
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Implicaciones pronósticas de la relación subventricular en el gliobastoma multiforme: caracterización clínica, radiológica y patológica
… Olig2, PGFA, EGFR, p53, MGMT, NFP, IDH1 e YKL-40 sobre una muestra de 204 pacientes, estratificados por grupos ( I, II, III, IV y V) en función de la relación subventricular, los cuales a su vez se subdividieron en profundos (I, II, V) y superficiales (III y IV). Los GBMs del grupo I se …