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Showing 1 to 16 of 16 for “"YB-1"”.
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Herstellung monoklonaler Antikörper gegen YB-1 und Charakterisierung ihrer Bindungseigenschaften
Y-box protein-1 (YB-1) belongs to the cold shock protein family. Members of this family are highly conserved in evolution and fulfill numerous functions in gene regulation and mRNA translation. Here, we have successfully generated six distinct anti-YB-1 monoclonal antibodies by immunizing mice with …
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Regulation des DNA-Polymerase-[alpha]-Gens durch den Transkriptionsfaktor YB-1
… Alpha (DPA) gene is identified as another YB-1 responsive gene with a Y-box and 3‘ inverted repeat sequence, designated DPA RE-1, in the serum-responsive promoter region. Overexpressed YB-1 concentration-dependently trans-activated DPA gene expression in reporter assays. Southwestern …
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Der Einfluss des Y-box-Proteins-1 (YB-1) auf den Notch-vermittelten Signaltransduktionsweg
… indicate an active secretion of Y-box protein-1 (YB-1) by mesangial and inflammatory cells. GFP-tagged YB-1 could be detected in microvesicular structures adjacent to the cell membrane after challenge with PDGF-BB in indirect immunofluorescence. YB-1 is known to fulfill pleiotropic functions in …
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Stress-induzierte posttranslationale Modifikationen des Y-box Proteins-1 (YB-1) beinhalten Acetylierung und Phosphorylierung
YB-1 is a member of the cold-shock domain protein superfamily. It performs a wide variety of cellular functions, including transcriptional and translational regulation, DNA repair, drug resistence and stress responses to extracellular signals. We demonstate increasing levels of acetylated …
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Identifizierung und funktionelle Charakterisierung des Spleißfaktors SRp30c als Interaktionspartner des Y-box-Proteins-1 (YB-1)
… DNA- and RNA-associated Y-box protein 1 (YB-1) specifically binds to splicing recognition motifs and regulates alternative splice site selection. Here, we identify the arginine/serine-rich SRp30c protein as an interacting protein of YB-1 by performing a two-hybrid screen against a human …
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Identifizierung und Kartierung von nukleären Import- und Exportsignalmotiven innerhalb des Y-box-bindenden Proteins-1 (YB-1)
Y-box Protein-1 (YB-1) is a multifunctional protein, which binds to DNA and RNA thereby influencing transcription and transplation. YB-1 consists of three domains: the N-terminal glycine-rich sequence, the cold shock domain (CSD) and the C-terminal domain. The latter contains alternating acidic and …
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Subzelluläre Lokalisation des Y-box-Proteins-1 (YB-1) in Mesangialzellen und Charakterisierung der dafür verantwortlichen Proteindomänen
… and RNA binding protein the cold-shock protein YB-1 serves multiple functions in the nucleus and cytoplasm, e.g. regulating transcription, RNA-processing, -translation and –storage. In the present study we examined the expression and localisation pattern of YB-1 in various models of glomerular …
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The N-terminal Domain of the Y-box Binding Protein YB-1 Plays a Major Role in Cell Proliferation and Apoptosis
<p>Y-box binding protein, YB-1, is a member of the cold shock domain superfamily of proteins. It is involved in a plethora of cellular functions, including cell proliferation. The molecular mechanisms governing the involvement of YB-1 in cell proliferation are still unclear. Earlier studies done in …
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Y-box binding protein-1 (YB-1) is essential for the growth and survival of HER-2 over-expressing breast cancer cells
… factor Y-box binding protein-1 (YB-1) to be a novel substrate of AKT which binds to epidermal growth factor receptor (EGFR) and HER-2 promoters once phosphorylated (Wu J et al. 2006). YB-1 is over-expressed in approximately 40% of breast cancers; its expression is strongly …
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Y-box binding protein-1 (YB-1) is a bio-marker of aggressiveness in breast cancer and is a potential target for therapeutic intervention
… he potential impact of Y-Box binding protein-1 (YB-1) as a marker of aggressiveness and cancer recurrence in breast malignancies by screening one of the largest tissue microarrays in North America. YB-1 is an oncogenic transcription/translation factor, which is over-expressed in the majority of …
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Identification of novel chemokine and chemokine-like mechanisms in leukocyte adhesion and atherosclerotic lesion formation
… progression. The first approach identified YB-1 as a new transcriptional regulator of the CC chemokine RANTES. RANTES is upregulated in mononuclear cells or deposited by activated platelets during inflammation and has been implicated in atherosclerosis and neointimal hyperplasia. Here, the …
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A yeast 2-hybrid screen to identify and characterize interaction partners of the cancer associated protein retinoblastoma binding protein 6
… protein interacting partners using a yeast 2-hybrid screen.In order to identify interaction partners of RBBP6, two well characterized domains of RBBP6, the N-terminal ubiquitin-like DWNN domain and RING finger domain, were used as baits in a yeast 2-hybrid screen of a human testis cDNA library. …
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Untersuchungen zum Transfer von E1A-deletierten Adenoviren in vielfachresistenten Tumorzellen durch Magnetofektion
… welche häufig den humanen Transkriptionsfaktor YB-1 im Kern enthalten, eine E1A-unabhängige adenovirale Replikation und virale Tumorzelllyse durchführen können. In der vorliegenden Arbeit sollte durch den Einsatz einer in der Gentherapie erst neuen Technologie - der Magnetofektion - eine …
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CHARACTERISATION OF Y-BOX PROTEIN 3 (MSY3) IN THE DEVELOPING MURINE CENTRAL NERVOUS SYSTEM
… has the redundant function with Y-box protein 1 (YB-1). Accordingly, in our system the MSY3 protein could be co-immunoprecipitated with YB-1. Importantly, developmentally regulated expression of MSY3 is not a hallmark of general translation apparatus, as several other proteins involved in …
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Die Rolle des prototypischen Kälteschockproteins Y-box Protein-1 im Magen-Adenokarzinom
… assessed prospectively until 2006. Monoclonal YB-1 antibody was used for immunostaining of paraffin sections. Protein expression was analyzed microscopically with the help of a score system according to Remmele et al.. Survival analyses were performed to evaluate the prognostic role of the …