Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"YAP/TAZ"”.
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Defining mechanisms directing YAP/TAZ-mediated tumorigenesis
… nuclear activity of yes-associated protein (YAP) and transcriptional co-activator with PDZ binding motif (TAZ) (YAP/TAZ). Uncontrolled nuclear YAP/TAZ activity evokes tumor-initiating properties in a range of epithelial-derived cancers, including oral and breast cancers, but their downstream …
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Biophysical profiling of YAP/TAZ dependent mechanical responses
… its downstream transcriptional co-activators, YAP and TAZ, play prominent roles in proliferation, regeneration, and wound healing. Interestingly, these are often found to be dysregulated in aged tissue. Yet, the precise mechanisms of YAP/TAZ regulation on cellular responses in an ageing niche …
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YAP/TAZ REGULATES ALVEOLAR REGENERATION AND RESOLUTION OF LUNG INFLAMMATION
… correlated with increased nuclear expression of Yap and Taz, the mediators of the Hippo pathway. Mice that lacked Yap/Taz in AECIIs exhibited prolonged inflammatory responses in the lung and were delayed in
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The Role of YAP/TAZ in von Willebrand Factor Gene Expression
… with higher synthesis in venous regions. YAP and TAZ are paralogous coactivators largely known for their role in the Hippo pathway. They function predominantly through interactions with TEAD transcription factors to regulate transcription of target genes, which ultimately execute the …
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Vinexin regulates autophagy through YAP/TAZ: implications for health and disease
… I focus on the transcriptional coactivators YAP and TAZ. The rationale here is: 1. YAP/TAZ activity is implicated in autophagy, 2. YAP/TAZ and vinexin are both linked to HCC. My data show that YAP/TAZ transcriptional activity is upregulated upon vinexin depletion. Moreover, increased …
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Preliminary Study on How Tumor Suppressor Nf2 Inhibits Transcriptional Coactivators Yap/Taz in the Developing Mouse Brain
… pathway effectors, transcriptional coactivators Yap/Taz. The molecular mechanism of how Nf2 regulates Yap/Taz is not understood. Here I showed that Nf2 regulated the Yap/Taz activity by decreasing the stability of Yap/Taz. The regulation was independent of Yap-S366 phosphorylation, which is …
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Papel de YAP/TAZ en la respuesta de células tumorales a estímulos activadores de receptores de TRAIL
… su rigidez. Los reguladores transcripcionales YAP y TAZ son los principales responsables de la detección de su grado de rigidez. En una matriz extracelular laxa, ambos factores permanecen inactivos en el citoplasma; sin embargo, cuando la matriz se vuelve más rígida, YAP/TAZ se translocan al …
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The Role of the Discoidin Domain Receptor-1 (DDR1) in Vascular Smooth Muscle Cell (VSMC) Mechanosensing
… stiffness-sensitive genes is mediated by a DDR1-YAP/TAZ nuclear complex. Ddr1-/- VSMCs had reduced nuclear YAP/TAZ, and loss of YAP/TAZ resulted in decreased DDR1 expression. DDR1 activation and increased substrate stiffness promoted DDR1 and YAP/TAZ nuclear localization. DDR1 and YAP/TAZ nuclear …
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UNRAVELING TAZ REGULATION IN BREAST CANCER BY CRISPR SCREENING
YAP and TAZ are transcriptional coactivators belonging to the Hippo signaling pathway. Their activity is regulated by a complex network of upstream signals. As consequence, they orchestrate a wide spectrum of downstream cellular responses. In physiological conditions, a precisely balanced …
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Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… incompletely understood. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ or WWTR1), key players of the Hippo pathway, have been implicated in the liver fibrosis, but the HSC-specific functions of YAP and TAZ are largely unclear. Here we have identified …
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Analysis of Hippo pathway signalling in schwannoma and meningioma
… augmented Hippo signaling i.e. interaction of YAP and TAZ, both co-activators of gene expression and the two main effectors of the Hippo signalling pathway, and TEAD, a group of transcription factors binding to YAP and TAZ. There resulting gene expression is associated with increased …
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Phenotypic screening and AI uncovers modulators of YAP and TAZ activity in glioblastoma
… main Hippo pathway transcriptional coactivators YAP and TAZ are master regulators of up to 70% of the entire glioma stem cell gene signature and so represent key molecular targets in the development of new therapeutic strategies for GBM. However, targeting these transcription cofactors in the …
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Yap and Taz Are Required For Neural Crest-Derived Cardiovascular Development
… septum, during embryogenesis. <em>Yap </em>and <em>Taz </em>are downstream effectors of the fundamental Hippo signaling pathway and are vital for proper organ and tissue development, yet their role in neural crest (NC)-derived heart formation is still largely unknown. We generated …
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Combinatorial Roles Of Skeletal Cell Yap And Taz In Bone Growth, Remodeling, And Repair
… co-activators Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) in bone are controversial, with evidence for each either promoting or inhibiting osteogenesis in vitro. Here, we used in vivo mouse models of combinatorial YAP/TAZ deletion from …
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Investigating The Role of Cd109 In Pancreatic Ductal Adenocarcinoma
… an association between CD109 expression and YAP/TAZ signaling through RPPA and RNA Sequencing data. This data establishes CD109 as a cell surface protein exclusively expressed in PDAC rather than healthy pancreatic tissue, demonstrating pro-oncogenic behavior and tumor initiation potential …
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Genetic Analysis of The Hippo Pathway In Mouse Liver
… mutation of these components, as well as the <em>Yap/Taz</em> double deletion mutation, reveals essential roles of the Hippo pathway in regulating hepatic quiescence and embryonic liver development. One of the key cellular mechanisms for the Hippo pathway’s involvement in these liver biological …
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Vestigial-Like 1 Is A Shared Targetable Cancer-Placenta Antigen Expressed By Pancreatic and Basal-Like Breast Cancers
… to the TEAD family of genes with the oncogenes, YAP/TAZ that promote malignancies through the Hippo signaling pathway. We show that VGLL1 may play a significant role in tumorigenesis by inducing tumor cell proliferation, migration, and invasion.</p>
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Interrogating therapeutic resistance to oncogenic KRASG12C-based therapies in colorectal cancer
… inhibitor combination. Moreover, we identify YAP-TAZ TEAD as a mechanism of acquired resistance in both our in vivo resistant models and in progressing patients. Finally, we interrogate novel YAP and pan-TEAD inhibitors for their clinical potential to overcome emergent resistance to KRASG12C …
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YAP and TAZ have Functionally Redundant Roles in Uveal Melanoma
… MAPK signaling and the transcriptional activator YAP. Recent zebrafish work established the importance of YAP and de-emphasized the role of MAPK in UM. Here we show that deletion of yap has no significant effect on the incidence, or kinetics, of GNAQQ209L-driven zebrafish UM. Additional …
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Establishment of MITF and TAZ as major determinants of uveal melanoma
… pathway, which signals through PLCβ4-MAPK and YAP, whereas CM is primarily driven by activation of the MAPK pathway. It has been well established that CM tumors are dependent on MITF, the master melanocyte transcription factor. Here, in stark contrast, we establish that MITF serves as a tumor …
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