Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Y27632"”.
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Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents
… and apoptosis. ROCK is inhibited bythe ATP mimic Y27632, which competitively binds the ATP binding site. All protein kinasespossess an ATP binding pocket and subtle differences in these pockets can allow thedevelopment of highly selective ATP mimicking inhibitors.The major part of my research was …
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Basal and agonist activated calcium sensitization pathways in murine gastrointestinal smooth muscles
… We also examined the effects of ROK inhibitor (Y27632), VDCC blocker (nicardipine), or PKC inhibitor (GF109203X) on the basal phosphorylation levels of MYPT1, CPI-17, and MLC20 in these three smooth muscles. The effects of Y27632, nicardipine, and Ca2+ free Kreb's solution on basal contraction …
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Signaling By Protease-Activated Receptors in Gastrointestinal Smooth Muscle
… to a minor extent by the Rho kinase inhibitor Y27632, whereas PAR2-induced sustained contraction was preferentially inhibited by Y27632. Activation of both PARl and PAR2 induced MLC20 phosphorylation, whereas phosphorylation of MYPTl and CPI-17 are receptor-specific: only PARl induced CPI-17 …
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Regulation des Neuritenwachstums durch Rho-GTPasen in primärkultivierten Hippocampusneuronen der Ratte
… ist und die Hemmung seines Effektors ROCK durch Y27632 <br>und H89 in primärkultivierten Hippokampusneuronen der Ratte zum Auswachsen von Neuriten führt. Y27632 in <br>hoher Konzentration ist durch Inhibition der PRK2 zudem in der Lage das axonale <br>Wachstum zu steigern. Desweiteren legt die …
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Die Angiotensin II induzierte Vasokonstriktion isolierter Arterien und deren Beeinflussung durch OxLDL
… konnte durch den Einsatz des Rho-Kinase Hemmers Y27632 gezeigt werde. Nach Inkubation kam es zu einer signifikant verringerten Ausprägung der Angiotensin II induzierten Vasokonstriktion. Auch durch die Blockade des AT1-Rezepors konnte die Angiotensin II induzierte Vasokonstriktion verhindert …
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Development of novel isolation methodologies for microvesicles and exosomes, as potential biomarkers for health (Therapeutic Lifestyle Changes), and use of microvesicle-delivered β-Gly in erythroleukaemia
… capable of being used to therapeutically inhibit Y27632, calpeptin and methyl-β cyclodextrin were shown to inhibit MV release. MV release from K562 cells was inhibited by Y27632 and calpeptin but less effectively by chlorpromazine or methyl-β-cyclodextrin, MV release from THP-1 acute monocytic …
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Structural and functional investigation of the trabecular outflow pathway
… the first study, we investigated the effects of Y27632, a derivative of Rho-kinase inhibitor that is being developed as next generation glaucoma drug with unclear IOP lowering mechanism, on aqueous humor outflow dynamics and associated morphological changes in normal human eyes and laser-induced …
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Il nucleotide extracellulare UTP: induzione della migrazione di cellule staminali emopoietiche CD34+
… Difficile (un inibitore delle Rho GTPasi) e con Y27632 (in grado di inibire specificatamente le cinasi ROCK). Nel complesso, i dati emersi in questo studio dimostrano la capacità del nucleotide extracellulare UTP di modulare la migrazione in vitro di progenitori emopoietici umani, nonché il loro …
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Investigation of the intracellular pathways required for 5HT-induced mitogenesis and their role in pulmonary hypertension.
… 5HTT+ mice. Administration of the ROCK inhibitor Y27632 had significantly greater effects in 5HTT+ mice compared to WT, highlighting the functional importance of the increase in ROCK 1 transcript. Hypoxia-induced pulmonary vascular remodelling and elevated right ventricular pressure were …
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Inhibition of extracellular vesicle release enhances cancer chemotherapy and inhibition of outer membrane vesicle release sensitises bacteria to antibiotic and bacteriophage therapy
… EGTA, Imipramine, Pantethine and Y27632 inhibited OMV release significantly. The role of EV inhibitors on antibiotic therapy was then further explored. The disc diffusion method and Minimum Inhibitory Concentration (MIC) was used to determine whether OMV inhibition affected …