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Showing 1 to 9 of 9 for “"Y-box protein-1"”.
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Die Rolle des prototypischen Kälteschockproteins Y-box Protein-1 im Magen-Adenokarzinom
… study was to define the prognostic role of Y-box protein-1 in patients with gastric cancer.BACKGROUND: Despite improvements in the surgical treatment of gastric adenocarcinoma, recurrence rates remain high in patients with advanced disease. The overall 5-year survival rate of patients that …
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Herstellung monoklonaler Antikörper gegen YB-1 und Charakterisierung ihrer Bindungseigenschaften
Y-box protein-1 (YB-1) belongs to the cold shock protein family. Members of this family are highly conserved in evolution and fulfill numerous functions in gene regulation and mRNA translation. Here, we have successfully generated six distinct anti-YB-1 monoclonal antibodies by immunizing mice with …
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Identifizierung und funktionelle Charakterisierung des Spleißfaktors SRp30c als Interaktionspartner des Y-box-Proteins-1 (YB-1)
The multifunctional DNA- and RNA-associated Y-box protein 1 (YB-1) specifically binds to splicing recognition motifs and regulates alternative splice site selection. Here, we identify the arginine/serine-rich SRp30c protein as an interacting protein of YB-1 by performing a two-hybrid screen against …
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Regulation des DNA-Polymerase-[alpha]-Gens durch den Transkriptionsfaktor YB-1
Y-box protein-1 involvement in cyclin A and B1 gene regulation has recently been demonstrated (Jurchott, K., Bergmann S., Stein U., Walther W., Janz M., Manni I., Piaggio G., Fietze E., Dietel M., and Royer H.D. (2003) J. Biol. Chem. 278, 27988-96). A more generalised role of this protein for …
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Identifizierung und Kartierung von nukleären Import- und Exportsignalmotiven innerhalb des Y-box-bindenden Proteins-1 (YB-1)
Y-box Protein-1 (YB-1) is a multifunctional protein, which binds to DNA and RNA thereby influencing transcription and transplation. YB-1 consists of three domains: the N-terminal glycine-rich sequence, the cold shock domain (CSD) and the C-terminal domain. The latter contains alternating acidic and …
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Der Einfluss des Y-box-Proteins-1 (YB-1) auf den Notch-vermittelten Signaltransduktionsweg
Recent studies indicate an active secretion of Y-box protein-1 (YB-1) by mesangial and inflammatory cells. GFP-tagged YB-1 could be detected in microvesicular structures adjacent to the cell membrane after challenge with PDGF-BB in indirect immunofluorescence. YB-1 is known to fulfill pleiotropic …
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CHARACTERISATION OF Y-BOX PROTEIN 3 (MSY3) IN THE DEVELOPING MURINE CENTRAL NERVOUS SYSTEM
… far from being fully understood. The family of Y-box proteins is involved in control of proliferation and transformation in various normal and pathological cellular systems, and therefore was considered as a candidate to exert such a function. Y-box proteins have a capacity to bind DNA and RNA, …