Global ETD Search
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Showing 1 to 2 of 2 for “"Xic1"”.
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Covalent modification and intrinsic disorder in the stability of the proneural protein Neurogenin 2
… with the cyclin-dependent kinase inhibitor Xic1. I will discuss the role of these interaction partners in xNgn2 stability. xNeuroD, a downstream target of xNgn2, is a related bHLH transcription factor which is stable. Here I describe domain swapping experiments between these two proteins …
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Mechanisms of cell cycle remodeling at the MBT during the development of Xenopus laevis embryos
… treated with two cell cycle inhibitors, GST-D34Xic1 and XChk1. Injection of embryos with GST-D34Xic1, a stoichiometric inhibitor of cyclin E/Cdk2, delays degradation of cyclin E and onset of the MBT. GST-D34Xic1 lowers Wee1 level, a kinase that maintains Cdks in an inactivate state. Eventual …