Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 322 for “"Xenograft"”.
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Vergleichende Etablierung und Charakterisierung eines orthotopen Kolonkarzinom-Xenograft-Modells
The human colon cancer cellline HT29 was investigated in various models regarding different criteria. The in-vivo-experiments were carried out with female SCID mice and consisted of subcutaneous cell injection, orthotopic cell injection into the cecal wall and orthotopic fixation of a tumor …
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STUDIES IN THE DEVELOPMENT OF A XENOGRAFT-DERIVED BONE SCAFFOLD
… harvest and potential for disease transmission. Xenografts sources are an attractive alternative because of their relatively unlimited supply from a pool of healthy donors but have historically been limited by the alpha-Gal epitope which may lead to immune system rejection of the graft. In the …
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The Development of a Xenograft-based Scaffold for Tendon and Ligament Reconstruction
Tendon and ligament injuries place a significant burden on the United States economy. Tissue-engineering is an emerging field that may potentially contribute to the development of novel therapeutic strategies in areas of ligament and tendon reconstruction surgery. Currently there is a limited …
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Metabolomic Investigation of Melanoma Metastasis in a Patient-Derived Xenograft Mouse Model
… cancer. We used a set of patient-derived xenograft mouse models of melanoma, in which the metastatic potential of individual tumor lines correlated strongly with the history of metastasis in the patient donors. Six tumor lines with low metastatic potential (L-met) and nine with high …
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Bevacizumab Effect on Topotecan Pharmacokinetics in a Murine Orthotopic Rhabdomyosarcoma Xenograft Model
… in an Rh30 orthotopic rhabdomyosarcoma xenograft model. However, the effects of BEV on the pharmacokinetics of TPT and the antitumor activity of TPT have not been evaluated. This study aimed to investigate the effect of BEV on TPT systemic and tumoral pharmacokinetics and to determine …
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Patient-derived and xenograft-derived organoids for characterization, drugs testing and biobanking of pediatric brain tumors
… Organoids (PDOs) and Patient- Derived Xenograft Organoids (PDXOs) established through the direct in vitro culture of primary tumors and patient derived xenograft (PDX)-derived tumors. We have developed a method for generating PDOs from a variety of pediatric brain cancers (ependymoma, …
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Exploring vasculogenic mimicry and anti-angiogenic therapy resistance within breast cancer patient-derived tissue xenograft models
… with AAT resistance in patient-derived tissue xenograft (PDTX) models of breast cancer by utilising bulk and single-cell transcriptomic data and developing optimised VM vessel visualisation modalities. A 3D imaging modality which is capable of visualising both host vessels and functional …
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Development of the chick chorioallantoic membrane (CAM) xenograft model to study metastasis and angiogenesis in autophagy deficient osteosarcoma cells
Osteosarcoma (OS) is the most common primary malignant bone cancer in children. Despite the improvement in multiagent chemotherapy, 5-year survival rate for metastatic OS is only 20% to 30%. One of the main reasons for failure in therapy is due to the activation of autophagy in metastasis and …
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Epigenetic Modulation In Braf Mutated Metastatic Colorectal Cancer
… susceptible to epigenetic influence. Mouse xenograft models of BRAFV600E mCRC were treated with vemurafenib or azacitidine, alone or in combination, to assess for changes in tumor size. Tumors and cell lines exposed to azacitidine were analyzed for methylation status and for gene expression …
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Identification of new therapeutic targets for undifferentiated pleomorphic sarcoma
… novel models of UPS from patient-derived xenograft models, (ii) identify compounds and target classes efficacious in UPS, and (iii) explore the anti-cancer effects of lead compounds, using the models developed. The discovery of new therapeutic options for UPS has been restricted by the …
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An Investigation into the Potential of Cell Therapies for Acute Myeloid Leukemia (AML) Treatment
… cells and extended survival in a Molm-13 GFP Luc xenograft model. Vγ9Vδ2 T cells also exerted an effective apoptotic effect in combination with venetoclax in the venetoclax resistant cell line, OCI-AML3, and improved survival in an OCI-AML3 GFP Luc xenograft model.</p>
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The Role and Mechanism of The Homeobox Gene Hoxa9 In The Growth of Epithelial Ovarian Cancer
… with poor outcomes in EOC patients and in mouse xenograft models of EOC. Whereas HOXA9 promoted EOC growth <em>in vivo</em>, HOXA9 did not stimulate autonomous tumor cell growth <em>in vitro</em>. On the other hand, HOXA9 was found to be associated with increased abundance of cancer-associated …
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Targeted Imaging Agents for Detecting Tumour Cell Death following Therapy
… maleimide for imaging tumour cell death in a xenograft murine advanced colorectal cancer. A one-pot, two-step automated synthesis of N-(5-[18F]fluoropentyl)maleimide using a GE TRACERlab FXFN automated module (within 58±5.8 min (n = 12), >98% radiochemical purity and 12±3% decay corrected …
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Allogeneic Double Negative T cell Therapy as a Novel Treatment for AML Patients
… reduce the leukemia load in patient-derived xenograft (PDX) models. Unlike CD4+ and CD8+ conventional T (Tconv) cells, DNTs do not attack normal allogeneic cells and normal xenogeneic tissues in vitro and in xenograft models. Further, potentials of using allogeneic DNTs as an off-the-shelf …
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Biological and Clinical Significance of Circulating Tumor Cells in Breast Cancer
… collected from the breast cancer (BC) MDA MB 231 xenograft model and characterized in two independent experiments using a microarray platform. CTCs were distinguishable from solid lesions by a set of 474 significantly differentially expressed genes. Among genes up-regulated in CTCs, the trefoil …
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Targeting Aldehyde Dehydrogenases in NF2-null Meningioma and Schwannoma
… and cell proliferation in the murine meningioma xenograft model. Nifuroxazide, which inhibits ALDH1A1 and ALDH1A3, drives a reduction in cell proliferation in dorsal root and vestibular ganglia schwannomas in the NF2fl/fl Periostin-CRE mouse schwannoma model, and in meningioma murine orthotopic …
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Development and characterisation of a novel chimeric antigen receptor against LGR5
… functional in vitro assays and in vivo tumour xenograft models. While LGR5scFv-CAR NK92 cells exhibited high specificity, they had poor efficacy in vitro and failed to survive in vivo. In contrast, LGR5scFv-CAR T cells showed specific and potent killing of LGR5high tumour cells in vitro, and …
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Efficacy of a Magnetic Drug Delivery System and Development of an Orthotopic Lung Tumor Imaging Model
… lung cancer animal-imaging model by subcutaneous xenograft and orthotopic lung implantation of NSCLC adenocarcinoma cells (A549) that were genetically modified with the human sodium iodide symporter gene (hNIS; SLC5A5) for the purpose of tumor imaging. Lung tumor growth was quantified using …
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The Impact of Radiation on Glioblastoma Evolution
… glioma stem-like cell (GSC) initiated orthotopic xenografts, and by assessing radioresistance with a reirradiation protocol. To determine the impact of ITH on intrinsic radiosensitivity, we performed whole-exome sequencing (WES) of multiple tumour fragments and corresponding patient-derived cell …
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