Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Xenobiotic metabolism"”.
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Xenobiotic Metabolism Genes and Clubfoot
… suggest that genetic variation in smoking metabolism genes may increase susceptibility to clubfoot. Based on this reasoning, we interrogated eight candidate genes, chosen based on their involvement in phase 1 and 2 cigarette smoke metabolism. Twenty-two SNPs and two null alleles in eight …
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Porcine model of xenobiotic metabolism
A xenobiotic is a foreign chemical substance found in the environment. The body removes xenobiotics by xenobiotic metabolism. Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination, and detoxification of xenobiotics introduced into the body. Orphan nuclear receptors play …
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Molecular Similarity and Xenobiotic Metabolism
… a data-mining approach for predicting sites of xenobiotic metabolism has been developed. The algorithm is based on a statistical analysis of the occurrences of atom centred circular fingerprints in both substrates and metabolites. This approach has undergone extensive evaluation and been shown …
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Xenobiotic metabolism and zebrafish (danio rerio) larvae
… is a requirement for the characterisation of the metabolism of xenobiotics in zebrafish larvae, due to the application of this organism to toxicity testing and ecotoxicology. Genes similar to mammalian cytochrome P450 (CYP) 1A1, CYP2B6, CYP3A5 and UDP-lucuronosyl-transferase (UGT) 1A1 were …
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Xenobiotic metabolism and mutation in diploid human lymphoblasts
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Nutrition and Food Science, 1982
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Xenobiotic metabolism and markers of genotoxicity in regulatory non-vertebrate ecotoxicological test species
… Methods were also developed to allow the xenobiotic biotransformation capability (via 7-ethoxyresorufin-O-deethylase or EROD activity) of both organisms to be measured. C. reinhardtii and D. magna possessed low, but measurable, basal EROD activity (0.03 pmol/minute/106 algal cells and 7 …
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Metabolism of Two Model Xenobiotics in Cultured Plant Cells
… in culture were found to oxygenate two model xenobiotics. Para-chlorophenyl methyl sulfide was S-oxidized by carrot, cotton, tobacco, alfalfa, and blacknightshade cell cultures. The rates of S-oxygenation by cultured plant cells were comparable to the rates in animal tissue preparations. The …
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Development of in silico models for the prediction of toxicity incorporating ADME information
… of toxicity and absorption, distribution, metabolism and elimination (ADME) parameters with an emphasis on absorption and xenobiotic metabolism. These two ADME properties largely determine bioavailability of a drug and, in turn, also influence toxicity. In vitro (Caco-2 cells and the …
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Evidence that ARNT plays a role in the regulation of the immunoglobulin heavy chain enhancer and identification of a putative ARNT ligand
… differentiation, cellular proliferation and xenobiotic metabolism. Among the members of the bHLH protein family are the products of the Pan gene Pan-1, Pan-2 and ITF -1. Pan proteins have been demonstrated to be required for proper B cell development, suggesting a unique role for Pan proteins …
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Catalytic and non-catalytic mechanisms involved in Glutathione S-transferase Pi mediated cytoprotection
… not known substrates for GSTP1. In addition to xenobiotic metabolism, GSTP1 has a key and varied role in cell regulation, showing to be a modulator of a stress response pathway and has been implicated in mediating sulfhydryl homeostasis.<br/><br/>The present study aims to address functions of …
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The Temporal and Contextual Relationship of NRF2 Activation and Cancer
… protein degradation, DNA repair, and xenobiotic metabolism. As such, NRF2 is critical in preserving cell function and viability, particularly during stress. Importantly, NRF2 itself is regulated via a variety of mechanisms, and the mode of NRF2 activation often dictates the duration of …
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Global deconvolution of heterotropic cooperativity in cytochrome P450 3A4
… P450 3A4 (CYP3A4) plays a central role in xenobiotic metabolism, and is of critical importance to both human health and the pharmaceutical industry. Its ability to interact with multiple molecules of the same substrate, or multiple substrates, leads to complex non-Michaelis kinetics, called …
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INTEGRATION OF QUANTUM-MECHANICAL AND MOLECULAR DOCKING APPROACHES IN GLOBAL METHODS FOR METABOLISM PREDICTION OF XENOBIOTICS
… discovery process are presented here: in silico xenobiotic metabolism prediction and QSAR modeling. The former can be used to optimize the ADMET profile of a potential candidate, thereby eliminating undesirable compounds. The latter strategy can be used to identify new hits and for hit-to-lead …
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Analysis of the Role of bHLH/PAS Proteins in Aryl Hydrocarbon Receptor Signaling
… (ARNT) and associates with specific cis xenobiotic response elements to activate transcription of genes involved with xenobiotic metabolism. AHR-mediated signal transduction has been evaluated thoroughly in the C57BL/6J mouse model system. This model system, however, may not be the most …
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Responses of respiratory system cells in vitro and in vivo to petrochemical combustion-derived ultrafine particles
… cells and that, in vitro, these PAHs activate xenobiotic metabolism pathways. We also present an in vivo analysis of bronchoalveolar lavage fluid (BALF) with inflammatory cell infiltrates, histopathological evidence of inflammation and particle retention, and gene expression analysis revealing …
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Mechanistic Studies of Flavin-Dependent Monooxygenases Involved in Bacterial Defense and Plant Metabolism
… and humans involved in defense pathways, xenobiotic metabolism, and natural product biosynthesis. One class of FMOs, Class B, carries out the oxidation of heteroatomic substrates, via hydroxylation, S-oxygenation, Baeyer-Villiger oxidation, and decarboxylation, using NAD(P)H as a coenzyme. …
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Human Cytochrome P450 2E1: Functional Comparison to Cytochrome 2A13 and 2A6
… plays the predominant role in human phase I xenobiotic metabolism. The CYP2 family, in particular, is known for it extensive Phase I metabolism of a majority of the xenobiotic compounds [1]. The goal of this project is to determine the structural foundation for the substrate selectivities of …
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The Association of Specific EPHX1 and GSTM1 Gene Polymorphisms with Phenytoin- or Smoking-Associated Birth Defects
… epoxide hydrolase (mEH) participates in xenobiotic metabolism, including the detoxification of the bioactive arene oxide metabolite of phenytoin and polycyclic hydrocarbons found in cigarette smoke. Another enzyme that accelerates phenytoin arene oxide detoxification is glutathione …
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Evaluation of the role of plant-derived chemicals in mosquito ecology and control
… to regulation of expression of genes related to xenobiotic metabolism and longevity. Collectively, these studies demonstrate that phytochemicals affect key ecological and behavioral processes in Aedes mosquitoes and offer promising leads for novel approaches to sustainable management of these …
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Investigating the Role of Cigarette Smoke and Alcohol in Oesophageal Squamous Cell Carcinoma
… CYP1B1, GSTM3, GSTM4 and UGT1 A6, involved in xenobiotic metabolism and a number of other metabolic pathways were also altered in response to CSC and EtOH treatment. However, these genes' involvement require further confirmation by RT-qPCR. This result of this study confirms that we have …
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