Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 53 for “"Xc-"”.
-
Modulating System xc- Activity As A Treatment For Epilepsy
… have no effective treatment options. System xc- (SXC), a cystine/glutamate antiporter expressed in astrocytes, is one such target that has been shown to play a critical role in establishing ambient extracellular glutamate levels in both health and disease. SXC has been shown to play a major …
-
XC. Un lenguaje orientado a componentes para programación de sistemas
… de un nuevo lenguaje de programación, llamado XC, usado como ejemplo de implementación de las guías de diseño estudiadas. Se trata de un lenguaje orientado a la programación con componentes que soporta también la programación orientada a objetos y la programación de sistemas. Esta pensado para …
-
Effect of Estradiol on xc- in Human Breast Cancer Cells
… potential target discovered in the 1980s is the xc- system, a cystine/glutamate antiporter. As knowledge about this system has increased, it has been found to have many characteristics of a possible target for cancer treatment. This transporter can be aberrantly expressed in many cancers …
-
Microwave-Accelerated Synthesis of Isoxazole Inhibitors of The System Xc- Transnporter
… Nervous System (CNS). Glutamate, a major excitatory amino acid in the CNS, works through four different classes of receptors; three that are heterogeneous, ionotropic excitatory amino acid (EAA) receptors (iGluRs), named N-methyl –D- aspartic acid (NMDA). …
-
Microwave-Accelerated Synthesis of Isoxazole Inhibitors of The System Xc- Transnporter
… Nervous System (CNS). Glutamate, a major excitatory amino acid in the CNS, works through four different classes of receptors; three that are heterogeneous, ionotropic excitatory amino acid (EAA) receptors (iGluRs), named N-methyl –D- aspartic acid (NMDA). …
-
The Snap! toolkit for developing sensor networks and application to XC skiing
Athletes, health professionals, animal specialists, meteorologists, and other investigators increasingly employ small, human-scale sensor networks in their disciplines. The sensor networks used by each field and study have unique requirements. Regardless, these networks all collect and store data, …
-
GLIOBASTOMA MULTIFORME UTILIZES SYSTEM Xc¯ FOR SURVIVAL UNDER OXIDATIVE STRESS AND PROMOTES CHEMORESISTANCE
… capabilities are sustained by system Xc<sup>–</sup>, a sodium-independent, electro neutral transporter that is found in the plasma membrane of GBM cells. System Xc<sup>–</sup> is composed of a regulatory heavy subunit (4F2hc) linked to a 12 transmembrane domain catalytic light chain …
-
Regulation of in vivo excitatory/inhibitory balance by the cystine/glutamate exchanger system xc-
<p>System xc- (Sxc-) is a cellular antiporter that links the import of L-cystine with the export of L-glutamate. In the central nervous system (CNS), this export contributes to the ambient glutamate levels found in the synaptic cleft. To wit, a 50% reduction in extracellular glutamate has been …
-
Orbital Functionals in Time-Dependent Density-Functional Theory
… disadvantages of common approximations for the exchange-correlation (xc) functional are also discussed as well as the basic ideas behind orbital functionals. In the first part of Chap. 3 the ground-state formalism of the DFT for fractional particle numbers is recapitulated. In the second part the …
-
Taming the Inverse and Forward Problems in Density Functional Theory
… total energy functional defined using some exchange-correlation (xc) functional $E_\text{xc}[n]$. Towards this end, the associated Euler-Lagrange equations, i.e. the Kohn-Sham equations, are often solved in practice, which demand a procedure that iterates an initial guess density to a …
-
New methods for quantifying the synchrony of contraction and relaxation in the heart
… dyssynchrony by utilizing a cross-correlation (XC) function to quantify dyssynchrony during post-processing as opposed to the quantitatively simplistic time-to-peak analysis that is currently utilized. The second method utilized standard cine cardiac magnetic resonance (CMR) images to quantify …
-
DFT calculations for cadmium telluride (CdTe)
… efficient creation of electron-hole pairs (or excitons) by solar photons. This has led to the research that dates back to 1950's and is currently ongoing in many parts of the world. A simple h eterojunction cell design was evolved in which p-type CdTe was matched with n-type Cadmium Sulfide …
-
High-Performance Low-Cost Catalysts for Water Electrolysis: A Computational and Experimental Study
… for the alkaline OER. A benchmark of different exchange-correlation (XC) functionals addresses the issue of the DFT level of theory for modelling the electronic structure of strongly correlated 3d metal oxides. The assessment of the XC reveals that PBE0 functional is the best for modelling 3d …
-
Precursors And Processes For The Growth Of Metallic First Row Transition Metal Films By Atomic Layer Deposition
… 135−145, 110−165, 100−135, and 105−175 ¢XC at 0.05 Torr, respectively, and thermally stabilities that range from 183−270, 108−248, 190−295, 240−308, and 180−310 ¢XC, respectively. Solution screening of these precursors with commercially available reducing agents revealed high reactivity …
-
Spin waves in doped graphene
… collective spin-wave modes arise from dynamical exchange and correlation (xc) effects. We here consider spin waves in doped paramagnetic graphene with adjustable Zeeman-type band splitting. The spin waves are described using time-dependent spin-density-functional response theory, treating …
-
Assessment of the scaled Perdew-Zunger self-interaction correction applied to three levels of density functional approximations
… theory if we could find the precise form of exchange-correlation energy $(E_{xc})$. However, this would not be computationally feasible. The density functional approximations (DFAs) are designed to be exact in the limit of uniform densities. They require a parametrization of the correlation …
-
BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Concentrations of L-glutamate in the CNS are regulated by a family of excitatory amino acid transporters (EAATs) that rapidly sequester and concentrate glutamate in glia and neurons, and thereby …
-
BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Concentrations of L-glutamate in the CNS are regulated by a family of excitatory amino acid transporters (EAATs) that rapidly sequester and concentrate glutamate in glia and neurons, and thereby …
-
Effect of Process Parameters and Material Attributes on Crystallisation of Pharmaceutical Polymeric Systems in Injection Moulding Process. Thermal, rheological and morphological study of binary blends polyethylene oxide of three grades; 20K, 200K and 2M crystallised under various thermal and mechanical conditions using injection moulding
… (Tm) and relative change in crystallinity (∆Xc%) compared to an unprocessed sample. Mould temperature (Tmould) was the most significant factor in all binary blend models. The relationship between Tmould and the two responses was positive non-linear at the Tmould ˂ Tc1. Injection speed was …
-
Realstrukturuntersuchungen von Seltenerd-Übergangsmetall-Borokarbiden
… Ni und Bor im gleichen Verhältnis in YNi2-xB2-xC. Es wurde ein Einfluß der Glühbehandlung auf die Realstruktur unabhängig von der Zusammensetzung festgestellt. Das Auftreten von dicht liegenden Stapelfehlern und der Bevorzugung der <110]-Versetzungen wurden in "inhomogenen" Proben …
Page 1 of 3