Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Xbp1 splicing"”.
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X-Box Binding Protein-1 is Important in Maintenance of Endothelial Integrity and Migration
… activation of spliced x-box binding protein-1 (XBP1), an endoplasmic reticulum stress response transcription factor, results in the development of atherosclerosis in apoE -/- mice. Histone deacetylases (HDACs) play a crucial role in transcriptional regulation through modulation of chromatin …
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Ire1 regulates cyp11a1 transcription to mediate steroidogenesis in the ovary
… MKC-4485 and MKC-3946 potently inhibited XBP1 splicing but had no effect CYP11A1 up-regulation in response to forskolin stimulation. Additionally, we sought to determine if XBP1u expression is necessary for up-regulating CYP11A1 in response to forskolin. Using RNA interference, XBP1 …
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The intrinsic role of SOCS1 in intestinal epithelial cells
… autophagy (P62), ER stress response (spliced Xbp1) and apoptosis (cleaved caspase 3 protein), as well as EdU incorporation proliferation assays were then performed. Our results indicate that the loss of Ifng and Socs1 is not affecting colonoid growth and renewal capacity of stem cells, goblet …
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Probing the protein homeostasis mechanisms in long-lived naked mole-rats
… In Chapter 3, RNA-based methods, including an Xbp1 splicing assay and quantitative PCR (RT-qPCR) assays were successfully established to probe the activation and outputs of the UPR in a NMR kidney fibroblast cell line in response to tunicamycin (TU) and thapsigargin (TG)-induced ER stress. In …
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Identification of a Novel Regulator of ER Stress-Induced Apoptosis
… ER stress and the UPR is the Ire1-mediated splicing of unspliced xbp1 (xbp1U) into the potent transcription factor spliced Xbp1 (Xbp1S). If the ER cannot return to homeostasis, the apoptotic program is activated. Programmed cell death (apoptosis) is an evolutionarily conserved, genetically …