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Showing 1 to 20 of 60 for “"Xanthine"”.
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The Enzymatic Oxidation of Aldehydes by Xanthine Oxidase
… tissues which catalyzed the oxidation of xanthine and hypoxanthine was recognized. The name given the enzyme was derived from its earliest recognized action, hence xanthine oxidase. Although little is known about the biological functions of the enzyme, the high affinity shown for xanthine …
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Investigating xanthine oxidase toxicity models in cultured cerebellar granule neurons
… evidence has been accumulating for a role for xanthine oxidoreductase (XOR)-generated toxic reactive oxygen species (ROS) in a variety of pathological conditions that affect different organ systems. This enzyme in mammals exists in two inter-convertible forms: xanthine dehydrogenase (XDH) (the …
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The Presence of Inhibitors and Activators of Xanthine Oxidase in Milk
Made available in DSpace on 2014-12-09T14:36:55Z (GMT). No. of bitstreams: 1 6612352.pdf: 5737638 bytes, checksum: c521d268a508c09922ae43947540dcc2 (MD5) Previous issue date: 1966
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Functional roles of butyrophilin 1a1 and xanthine oxidoreductase in lactating mammary gland
Butyrophilin 1a1 (BTN) and xanthine oxidoreductase (XOR) are expressed in the lactating mammary gland and are secreted into milk in association with lipid droplets. Disruption of either the BTN or XOR gene in mice causes the accumulation of large pools of lipid in the cytoplasm, thus suggesting …
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Effects of xanthine oxidase inhibitors in pulmonary hypertension associated with chronic lung disease
… related pulmonary hypertension is allopurinol (a xanthine oxidase inhibitor) which decreases both uric acid and oxidative stress. We hypothesised that allopurinol could regress RVH in patients with pulmonary hypertension associated with chronic lung disease (PH-CLD).In a double-blind, randomised …
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Renal and Blood Pressure Effects of Xanthine Oxidase Inhibitors in the FAST trial
… pressure and control of hyperuricaemia with xanthine oxidase inhibitors. Data from the Febuxostat versus Allopurinol Streamlined (FAST) trial is presented in three studies:1) Up-Titration of Allopurinol in Patients with Gout. Patients recruited into the FAST trial have their sUA levels …
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Cloning, expression, purification and drug targeting of Plasmodium falciparum hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT)
The research concerns sub-cloning the gene for HGXPRT from Plasmodium falciparum from a vector with a His-tag facility to one without, expression of the protein in E. coli, and purification. On an analytical scale (40 ml culture), a purification procedure was developed that involves extraction of …
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The Effect of Allopurinol and Inosine Administration on Xanthine Oxidoreductase Gene Expression, Mitochondrial Respiration, and Inflammation in Broiler Chickens
… degradation, uric acid is generated in the xanthine/hypoxanthine reactions catalyzed by xanthine oxiodreductase (XOR). In the first study, inosine, a purine precursor, was fed to 3 groups of 5 birds: Group 1 was fed 0 (control), Group 2, 0.6 mols inosine/kg feed (INO) and Group 3, INO …
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Ab Initio Treatment of Complex Systems Kohn-Sham Orbitals for Multi Reference Methods and the Base Pairing Properties of Xanthine
Die vorliegende Arbeit besteht aus zwei Teilen. Der erste untersucht die Eignung von LHF-Orbitalen für Multireferenzverfahren. Das Ziel dieses Teils ist eine effizientere Berechnung angeregter Zustände, was zur spektroskopischen Charakterisierung vieler organischer und bioorganischer Moleküle …
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Study of melissopalynological, physical and chemical properties, antioxidant and xanthine oxidase inhibition activity of heterotrigona itama honey in Johor, Malaysia
… and chemical properties, antioxidant and xanthine oxidase inhibition activity of Heterotrigona itama honey from six selected area in Johor, Malaysia. Plant sources of honey were identified by melissopalynological analysis, and multiply methods were conducted to investigate the physical and …
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Defined Dimensional Alterations in Enzyme Substrates. Synthesis and Enzymatic Evaluation of Some Lin-Naphthopurines
… extended dimensional derivatives of hypoxanthine and xanthine. These compounds, lin-naphthohypoxanthine and lin-naphthoxanthine, exhibited intense fluorescence. lin-Naphthoxanthine was not oxidized to lin-naphthouric acid by xanthine oxidase but functioned as a noncompetitive inhibitor. …
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The role of molybdenum in the formate dehydrogenase of methanobacterium formicicum
… pterin similar to the molybdopterin of xanthine oxidase. In contrast to the molybdopterin from xanthine oxidase the formate dehydrogenase cofactor was unable to complement the cofactor-deficient nitrate reductase of Neurospora crassa mutant nit-1 and possessed two phosphate groups. …
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Interaction of phthalazines with molybdenum hydroxylases. Phthalazine and its 1-substituted derivatives as substrates, inhibitors and inducers of aldehyde oxidase and xanthine oxidase, both in vitro and in vivo.
… molybdenum hydroxylases, aldehyde oxidase and xanthine oxidase, has been investigated both in vivo and /Ok in vitro. Metabolic studies, carried out by treating rabbits with both cold and 14C-labelled phthalazine, have shown that this compound is extensively metabolised in vivo, the major …
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Antioxidant activity of Mn-salophen complex and its effects on antioxidant enzymes in Escherichia coli
… The SOD-like activity of the complex in the xanthine-xanthine oxidase/cytochrome <i>c</i> assay was 1450 units/mg salophen. The SOD activity of the complex was suppressed 50% in the presence of EDTA (1 mM), but was not altered in the presence of bovine serum albumin (1 mg/ml) or crude protein …
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More evidence for H2O2-mediated oxidative stress in vitiligo-increased epidermal DNA damage / repair.
… see (Schallreuter, Bahadoran et al. 2008). Xanthine dehydrogenase / xanthine oxidase (XDH / XO) catalyses the oxidative hydroxylation of hypoxanthine to xanthine followed by xanthine to uric acid, the last two steps in purine degradation pathway. Under oxidative conditions, XDH is converted …
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Defined Dimensional Changes in Purine Analogues
… for and alternative-substrate inhibitors of xanthine oxidase. In each case, the product of enzymatic oxidation has been isolated and compared with the same material synthesized chemically. These oxidation products have been identified as the corresponding benzoalloxanthines.
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The involvement of free radicals in the casual mechanism of Motor Neurone Disease
… horn of the spinal cord than in other cells. Xanthine oxidase (XO) activity is a potential source of superoxide (07) (metabolism of xanthine to uric acid by XO produces 07) its subcellular location in the perikatyon of the spinal cord was shown to be associated with mitochondria. Thus the …
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OPTIMIZING DIAGNOSTIC ACCURACY IN CANINE URINARY TRACT INFECTIONS: FUTURE DIRECTIONS TO REDUCE ANTIMICROBIAL MISUSE IN VETERINARY PRACTICE
… (uNGAL), urinary interleukins 8 and 6, urinary xanthine oxidase, and urinary myeloperoxidase. Among these, urinary interleukin-8 and urinary xanthine oxidase are identified as the most promising disease markers, highlighting the need for further research, particularly including comparison with …
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The search for small molecule inhibitors of histone acetylation
… towards cancer cell growth inhibition, HAT, xanthine<br/>oxidase, luciferase and p21 reporter activity. Analogue KC_19 was identified to inhibit HAT and<br/>xanthine oxidase activity with equivalent potency to anacardic acid. KC_39 (IC50 = 18.2 ± 2.6 ?M)<br/>was the most potent analogue in …
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