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Showing 1 to 20 of 31 for “"XRPD"”.
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Preparation of amorphous forms to increase the solubility of poorly soluble drugs using spray drying
… Calorimetry (DSC) and Powder X-ray Diffraction (XRPD). The data showed that the crystalline model drugs were converted to amorphous form upon spray drying, whereas the physical mixtures did not change their crystallinity. The effect of the amorphous forms produced by Spray drying on apparent …
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Physical analysis of solid solution formulations
… to evaluate the different formulations such as XRPD, VT XRPD, DSC, dissolution and microscopy. The cooling temperature of the formulation from melt has a great impact on forming amorphous CBZ in PEG mixture. PEG 300 did show the ability to reduce the crystallinity in the other PEG used and to …
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Metal phosphates: From syntheses and structures to applications in sorption, catalysis and teeth erosion protection
… (TGA) together with X-ray powder diffractometry (XRPD) to elucidate the loss of guest molecules and the stability of the host framework. Crystals grown from the reaction of piperazinedium phosphate, (C4H12N2)(HPO4)2 with Co(II) or Ni(II) at normal pressure and temperature gave only a …
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Production and characterization of composite nano/micro sized particles by rapid expansion of supercritical solutions (ress) co-precipitation
… the polymeric binder. X-ray Powder Diffraction (XRPD) analysis indicates polycristalline structure of RDX in the product with a crystallite size of 42 nm. The content of RDX in the composite particles is in the range 70-73% by mass as determined by Gas Chromatography-Mass Spectroscopy (GC-MS) and …
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Implementing process analytical technology (PAT) tools for the analysis and control of manufacturing processes during hot-melt extrusion
… of the products, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), near infrared (NIR) spectroscopy, variable temperature x-ray powder diffraction (VTXRPD) and dissolution studies were implemented in various drug delivery systems manufactured by HME. Paracetamol …
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Identification of tephras from the Eastern Mediterranean using solid state techniques
… involved the use of X-ray powder diffraction (XRPD) to identify the minerals present in the materials, electron probe microanalysis (EPMA) to obtain the chemical composition of the glassy components, and scanning electron microscopy (SEM) to study the morphology of the glassy components. The …
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Development of cocrystals of water insoluble active substances with inactive excipients by using hot melt extrusion
… calorimetry (DSC) and X-ray powder diffraction (XRPD); it was found that the screw configuration in TSE plays an important role in the production of high quality cocrystals compared to cocrystals produced using SSE. Furthermore, samples collected from the three zones of the barrel of the extruder …
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Fingerprinting analysis of non-crystalline pharmaceutical compounds using high energy X-rays and the total scattering pair distribution function
… conventional X-ray powder diffraction (XRPD) patterns become broad and featureless in these cases and are not useful for differentiating between different local molecular packing arrangements. In this thesis, we introduce the use of high energy X-rays coupled with total scattering pair …
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Formulation and physico-chemical characterisation of novel films and wafers for mucosal drug delivery
… the residual water content of both formulations. XRPD was used to assess the different forms (amorphous or crystalline) of the various components, including the model drugs. Scanning electron microscopy provided topographic information with regard to surface architecture of the films and wafers. …
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New chalcogenide-based phase-change materials for potential data storage applications
… analysis (DTA, DSC,UV-Vis), X-ray diraction (XRPD, PDF), and electron microscopy (TEM, SEM).
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Structural and magnetic characterisation of some mixed metal oxides and oxyhalides
… have been investigated using XRPD, NPD and magnetic susceptibility measurements. An earlier characterisation of Pb\(_8\)WO\(_{10}\)Cl\(_2\) suggested a deficit on all atom sites within the unit cell. This work suggests a different structure with an intact cation and main oxygen …
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Development of a Dry Powder Inhaler and Nebulised Nanoparticle-Based Formulations of Curcuminoids for the Potential Treatment of Lung Cancer. Development of Drug Delivery Formulations of Curcuminoids to the Lungs using Air Jet Milling and Sonocrystallisation Techniques for Dry Powder Inhaler Preparations; and Nanoemulsion and Microsuspension for Nebuliser Formulations
… using laser diffraction, SEM, IGC, DSC and XRPD, respectively. Several DPI formulations with a variable particle size of curcuminoids were prepared in two drug-carrier ratios (1:9 and 1:67.5). The best performance of the DPI formulations of the sonocrystallised particles, which exist in …
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Investigating the Dissolution and Permeation Properties of Flufenamic Acid Cocrystals
… calorimetry (DSC) and x-ray powder diffraction (XRPD) confirmed the formation of cocrystals. (2) Effect of polymers on cocrystals supersaturated solution: The influence of three polymers (polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and a copolymer of N-vinly-2-pyrrolidone (60%) and …
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Mechanistic Understanding of Co-crystal solubility and dissolution by using a combination of Experimental and Molecular Modelling Techniques
… calorimetry (DSC) and X-ray Powder Diffraction (XRPD) confirmed the formation of co-crystals. (2) The effect of polymers on the surface dissolution of co-crystals: The influence of three polymers (polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and a copolymer of N-vinly-2- pyrrolidone …
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Pharmaceutical analysis and in-vitro aerodynamic characterisation of inhaled theophylline formulations containing drug particles prepared by supercritical fluid processing. Chromatographic, spectroscopic, and thermal analysis of micron-sized theophylline particles prepared by supercritical fluid technology and in-vitro evaluation of their performance as inhaled dry powder formulations.
… the crystal structure [X-ray powder diffraction (XRPD)], the structure and conformation [(FTIR), Fourier-transform Raman spectroscopy (FT-Raman)], and the morphology and particle size [scanning electron microscope (SEM)]. While, thermal gravimetric analysis (TGA), and differential scanning …
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Insight into Nucleation Kinetics of Flufenamic Acid Cocrystal Formulation in Solution: Investigating the Role of Polymeric Excipients through Combined Experimental and Computational Approaches
… techniques including X-ray powder diffraction (XRPD), attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR), and differential scanning calorimetry (DSC), to assess structural and thermal properties. PEG significantly prolonged induction times with increases of 8.2-fold …
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Effects of Polymers on Carbamazepine cocrystals phase transformation and release profiles
… Calorimetry (DSC), X-Ray Powder Diffraction (XRPD), Raman spectroscopy (Raman) and Scanning Electron Microscopy (SEM). JMP 11 software was used to design the formulation. It has been found that Hydroxupropyl methylcellulose (HPMC) cannot inhibit the transformation of CBZ-NIC cocrystals to …
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Hot melt extrusion (HME) processing for the development of lipid oral solid dosage forms
… calorimetry (DSC) and X-ray powder diffraction (XRPD) exhibited Df-Na either in the crystalline or amorphous state depending on the processing methodology. EDX was employed to validate the homogeneous distribution of drug on the surface of the compressed tablets. Solid lipid matrices exhibited …
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Development of novel formulations for mucosal delivery of protein based drugs
… (CD) while xerogel crystallinity was examined by XRPD. SEM micrographs showed highly porous xerogels due to annealing which allowed for high drug loading and hydration capacities of the dialysed and annealed xerogels which also exhibited optimal moisture content for maintaining protein stability. …
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Co-processing of drugs and co-crystal formers and its effect on pharmaceutical dosage-form performance. Co-crystallization of urea/ 2-methoxybenzamide, caffeine/ malonic acid, caffeine/ oxalic acid and theophylline/ malonic acid systems: Solid-state characterization including imaging, thermal, X-ray and Raman spectroscopic techniques with subsequent evaluation of tableting behaviour
… of the co-crystals has been carried out using XRPD, Raman spectroscopy, DSC, TGA, hot-stage microscopy and SEM. After preparation of co-crystals, tablets have been produced from co-ground-, co-precipitated-, and physical mixtures using Compaction Studies Press (Kaleva), and the data were …
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