Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"XRCC1"”.
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XRCC1 & DNA MTases : direct and indirect modulation of inflammation-induced DNA damage
… and BER-intermediate levels were evaluated in XRCC1 proficient and deficient cells, following exposure to the peroxynitrite donor, SIN-1 and to NO*. Using the alkaline comet assay, we find that while XRCC1 proficient and deficient CHO cells incur equivalent levels of SIN-1 induced …
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The role of ATM responding to DNA damage induced by Xrcc1 deficiency during oligodendrocyte genesis
… make the proper mice model for A-T, we generated Xrcc1 and Atm double knockout mice (hereafter referred to as Xrcc1nes-cre; Atm-/-) to determine the function of DNA damage sensor kinase Atm upon persistent DNA damage condition by Xrcc1 inactivation during brain development. Xrcc1 is a scaffolding …
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Dose-rate-effects in XRCC1 wild-type and mutant CHO cell lines using An ²⁴¹AM source
… on both the AA8 (wild-type CHO cells) and EM9 (XRCC1 null CHO mutants) cell lines. In particular, this study performed clonogenic survival and growth assays to determine the radiations/ effect on the cells proliferative capacity. It was hypothesized that the XRCC1 null mutants would show greater …
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Which Gene is a Dominant Predictor of Response during FOLFOX Chemotherapy for the Treatment of Metastatic Colorectal Cancer, MTHFR or XRCC1 Gene?
… 6 1. DNA preparation and amplification MTHFR and XRCC1------------------- 6 2. Nucleotide sequencing---------------- 7 3. Fluorescence-based direct sequencing.-7 D. 통계학적 분석 --------------------------- 11 III. 결과 ----------------------------------------- 12 A. 대상 환자의 특성--------------------------12 …
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Understanding The Repair Mechanisms at Ionizing Radiation-induced Damage in The Human Genome
… cells. This stimulation was dependent on XRCC1 phosphorylation by casein kinase 2 (CK2) that enhanced the interaction of XRCC1 with the end resection enzymes Mre11 and CtIP. The XRCC1 immunocomplex isolated from U2OS cells had Alt-EJ activity in vitro; this activity was significantly …
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DNA repair genetic polymorphisms and breast cancer in the Portuguese population
… the association of different polymorphisms ( XRCC1 Arg399Gln, XPD Lys751Gln, RAD51 G135C, XRCC3 Thr241Met, TP53 Arg72Pro and TP53 PIN3 Ins16bp) belonging to the DNA damage signalling and repair mechanisms with breast cancer susceptibility, in familial and sporadic breast cancer, in the …
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Tailored chemotherapy based on genomic polymorphisms for metastatic colorectal cancer treated with 5-fluorouracil plus oxaliplatin or irinotecan in Korean patients
… RFLP 방법을 사용하여 TS, MTHFR-977, XPD-751, GSTP1-105, XRCC1-399, UGT1A1*28 유전자에 대해 분석한 후 다형성에 따라 약제를 선택하여 항암화학치료를 시행하였다. 3주기 시행 후 반응도를 평가하였다. 결과: 44명의 환자가 연구에 참여되었으며 32명의 환자에서 FOLFOX용법으로, 12명의 환자에서 FOLFIRI용법으로 치료받았다. 전체 환자에서 완전관해는 없었으며 맞춤화학치료에 대한 반응율은 43.2%(19명)였다. 유전자 다형성에서 XPD-751, GSTP1-105, …
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Arsenic in drinking water caused ultra-structural damage in urinary bladder but did not affect expression of DNA damage repair genes or repair of DNA damage in transitional cells
… (ATM), X-ray repair cross-complementing group 1 (XRCC1), excision repair cross-complementing group 3/Xeroderma Pigmentosum B (ERCC3/XPB), and DNA polymerase beta genes were not altered, as measured by real time RT PCR. These results suggested either that DMA(V) affects DNA repair without affecting …
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Key Genotypes and the Response to Nutrient Supplementation in Crohn’s Disease
… and CD activity (PPARG); colorectal adenoma (XRCC1), and inflammation (SCD). Project Two To investigate, through a double blinded, randomized, placebo, crossover, 12 week trial, the response of 30 healthy adults to a commercial nutrient supplement (containing antioxidants, vitamin D (25(OH)D3) …
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Action of Tyrosyl DNA Phosphodiesterase on 3'-Phosphoglycolate Terminated DNA Strand Breaks
… In nuclear extracts, hTdp1 association with XRCC1, a single-strand repair protein, showed to increase the PG-processing activity of Tdpl up to 4 times. Whole-cell extracts containing mutant Tdpl derived from patients suffering from spinocerebellar axonal neuropathy (SCAN1) were found to be …
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A pilot study to identify links between genetic variation and shoulder pain and dysfunction after breast cancer radiotherapy
… in TGF-ß, two in ATM, one in SOD2 and one in XRCC1, using PCR technologies and TaqMan allelic-discrimination probes. The resultant genotypes were analysed using multivariate analysis, including inferred haplotype analysis to search for association to shoulder pain and morbidity after …
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Prognostic biomarkers for head and neck squamous carcinoma
… and tumour hypoxia including PTEN, Ku80, RadSl, XRCC1, ERCC1 and HEP-la was tested using immunohistochemistry staining IHC. The tested genes were found to be expressed at varying levels in HNSCC patients. Associations between the level of the expression and gender, site of origin, tumour …
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Genetic Susceptibility to Arsenic Exposure and Arsenical Skin Lesion Prevalence in Bangladesh
… SNPs in DNA repair genes (OGG1, rs1052133; XRCC1, rs25487 and rs1799782; XRCC3, rs861539; ERCC2, rs1052559; ERCC5, rs17655; and LIG4, rs1805388) and skin lesion prevalence, as well as possible interactions of these associations on the additive scale by various environmental factors. In …