Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"XPLN"”.
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Molecular mechanisms of mammalian cell survival and differentiation
… understood. In Chapter 2, I identified XPLN, a RhoGEF, as an endogenous inhibitor of mTORC2 kinase activity towards Akt. Furthermore, I showed that the GEF activity of XPLN is dispensable for its regulation of mTORC2 and Akt, whereas an N-terminal 125-amino acid fragment of XPLN is both …
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Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
Lipids and proteins are two major components of cells, which are crucial for structural integrity and maintenance of cellular homeostasis by integrating various extracellular and intracellular cues. Lipids are involved in the regulation of cellular functions and can interact with proteins and …